Successful anti-tumor effects with two novel bifunctional chemotherapeutic compounds that combine a LAT1 substrate with cytotoxic moieties in aggressive T-cell lymphomas

Autor: Carlos Murga-Zamalloa, Shaun Webb, John Reneau, Alejandro Zevallos, Pierina Danos-Diaz, Vanessa Perez-Silos, Mirna Rodriguez, Guangyao Gao, Wolf-Nicolas Fischer, Bernd Jandeleit, Ryan Wilcox

Publikováno v: Leukemia Research Reports, Vol 21, Iss , Pp 100398- (2024)

T-cell lymphomas are aggressive neoplasms characterized by poor responses to current chemotherapeutic agents. Expression of the l-type amino acid transporter 1 (LAT 1, SLC7A5) allows for the expansion of healthy T-cell counterparts, and upregulation

Externí odkaz: https://doaj.org/article/8998a2e3b96f4b23b775c3aba7f40590

Successful anti-tumor effects with two novel bifunctional chemotherapeutic compounds that combine a LAT1 substrate with cytotoxic moieties in aggressive T-cell lymphomas.

Autor: Murga-Zamalloa C; Department of Pathology, University of Illinois at Chicago, 840 S Wood Street, 260 CMET, Chicago, IL 60607, United States., Webb S; Department of Pathology, University of Illinois at Chicago, 840 S Wood Street, 260 CMET, Chicago, IL 60607, United States., Reneau J; Department of Internal Medicine, Ohio State University, Columbus, OH 43210, United States., Zevallos A; Department of Pathology, University of Illinois at Chicago, 840 S Wood Street, 260 CMET, Chicago, IL 60607, United States., Danos-Diaz P; Department of Pathology, University of Illinois at Chicago, 840 S Wood Street, 260 CMET, Chicago, IL 60607, United States., Perez-Silos V; Department of Pathology, University of Illinois at Chicago, 840 S Wood Street, 260 CMET, Chicago, IL 60607, United States., Rodriguez M; Quadriga BioSciences, Inc., Los Altos CA 94022, United States., Gao G; Acme Bioscience, Inc., Palo Alto, CA 94303, United States., Fischer WN; Quadriga BioSciences, Inc., Los Altos CA 94022, United States., Jandeleit B; Quadriga BioSciences, Inc., Los Altos CA 94022, United States., Wilcox R; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, United States.

Publikováno v: Leukemia research reports [Leuk Res Rep] 2023 Nov 22; Vol. 21, pp. 100398. Date of Electronic Publication: 2023 Nov 22 (Print Publication: 2024).