Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Danny Soon"'
Autor:
Deborah Amanda Goh, Yanhong Dong, Wah Yean Lee, Way Inn Koay, Stephen Ziyang Tay, Danny Soon, Christopher Chen, Claire Frances Brittain, Stephen Loucian Lowe, Boon-Seng Wong
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96874 (2014)
BACKGROUND: Diabetes is reported to be linked to poorer cognitive function. The purpose of this study is to examine (a) clinical correlation between cognitive function and the biochemical perturbations in T2DM, and (b) the impact of statin treatment
Externí odkaz:
https://doaj.org/article/d93f933e6c7c44479a9192acde6b9a24
Autor:
Zhen Ling Teo, Ann Kwee, John CW Lim, Carolyn SP Lam, Dean Ho, Sebastian Maurer-Stroh, Yi Su, Simon Chesterman, Tsuhan Chen, Chorh Chuan Tan, Tien Yin Wong, Kee Yuan Ngiam, Cher Heng Tan, Danny Soon, May Ling Choong, Raymond Chua, Sutowo Wong, Colin Lim, Wei Yang Cheong, Daniel SW Ting
Publikováno v:
Annals of the Academy of Medicine, Singapore. 52:199-212
Artificial intelligence (AI) and digital innovation are transforming healthcare. Technologies such as machine learning in image analysis, natural language processing in medical chatbots and electronic medical record extraction have the potential to i
Autor:
Joanne Foster, Juliet McColm, Kimberley Jackson, Sitra Tauscher-Wisniewski, Subha Suriyapperuma, Danny Soon, Steven Swanson, Claire Brittain
Publikováno v:
British Journal of Clinical Pharmacology. 83:1654-1667
Aims The safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of single and multiple doses of a novel mGlu2 agonist were assessed in healthy males. Methods In two, Phase 1 investigator- and subject-blind, placebo-controlled studies, oral
Autor:
Mary E. Seger, Helle Linnebjerg, Amparo de la Peña, Danny Soon, Patricia Brown-Augsburger, Shobha Reddy, Adam Scott, Michael Allen Dobbins
Publikováno v:
Clinical Pharmacology in Drug Development
Insulin lispro 200 U/mL (IL200) is a new strength formulation of insulin lispro (Humalog®, IL100), developed as an option for diabetic patients on higher daily mealtime insulin doses. This phase 1, open‐label, 2‐sequence, 4‐period crossover, r
Autor:
Danny Soon, Shufen T. H. Lim, Vikram Sinha, Kenneth F. Mace, S. L. Choi, Kwee Poo Yeo, Daniel C. Howey
Publikováno v:
The Journal of Clinical Pharmacology. 54:792-799
LY2605541 is a novel basal insulin analog with a prolonged duration of action. Two Phase I studies assessed LY2605541 pharmacokinetics (PK), glucodynamics (GD), and tolerability in healthy subjects. In Study 1, 33 subjects received single subcutaneou
Autor:
Danny Soon, Wei Fun Cheong, Jun Kusunoki, Sin Man Lam, Jeffrey William Stebbins, Markus R. Wenk, Bowen Li, Guanghou Shui, Xinrui Duan, Ronan P. Kelly
Publikováno v:
Metabolomics. 9:786-799
While pathological alterations in plasma neutral lipids with type 2 diabetes mellitus (T2DM) has been relatively well-characterized, only limited information is available on the variations in global polar lipidome (glycerophospholipids and sphingolip
Autor:
Juliet, McColm, Claire, Brittain, Subha, Suriyapperuma, Steven, Swanson, Sitra, Tauscher-Wisniewski, Joanne, Foster, Danny, Soon, Kimberley, Jackson
Publikováno v:
British journal of clinical pharmacology. 83(8)
The safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of single and multiple doses of a novel mGlu2 agonist were assessed in healthy males.In two, Phase 1 investigator- and subject-blind, placebo-controlled studies, oral doses of prodr
Autor:
Helle Linnebjerg, David E. Coutant, Lai Hock Tan, Danny Soon, Xin Zhang, Mary E. Seger, Laiyi Chua, Eric Chen Quin Lam
Publikováno v:
Clinical pharmacology in drug development. 6(6)
LY2963016 (LY IGlar) and Lantus (IGlar) are insulin glargine products with identical amino acid sequences. This was a phase 1 single-site, randomized, subject- and investigator-blinded, 4-treatment, 4-period crossover study to compare the pharmacokin
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 37:3-24
Ethnic differences in warfarin maintenance doses have been documented amongst the three major Asian ethnic groups (Chinese, Malay and Indian) in Singapore. Studies have shown that cytochrome P450 2C9 (CYP2C9) polymorphisms alone did not entirely acco
Autor:
Richard W. Peck, Alan Pan, Leyan Teng, Danny Soon, Kwee Poo Yeo, Stephen D. Wise, Stephen L. Lowe
Publikováno v:
Psychoneuroendocrinology. 31:473-484
The objective of the study was to assess l-5-hydroxytryptophan's (l-5HTP) augmentation effect on the neuroendocrine response to a SSRI (citalopram). A neuroendocrine challenge study was conducted in healthy Asian male subjects. The neuroendocrine res