Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Danny Riethorst"'
Autor:
Marlies Braeckmans, Joachim Brouwers, Danny Riethorst, Cécile Servais, Jan Tack, Patrick Augustijns
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 119 (2022)
The bioavailability of lipophilic drugs may or may not be increased when administered with food due to increased solubilisation in fed state gastrointestinal (GI) fluids. The in vivo interplay between drug solubilisation, lipid phase digestion and dr
Externí odkaz:
https://doaj.org/article/b6838333fb984d3bad448e65af00e919
Autor:
Martin Brandl, Joachim Brouwers, Mette Sloth Bohsen, Patrick Augustijns, Philipp A. Elvang, Paul C. Stein, Danny Riethorst, Annette Bauer-Brandl
Publikováno v:
Elvang, P A, Bohsen, M S, Stein, P C, Bauer-Brandl, A, Riethorst, D, Brouwers, J, Augustijns, P & Brandl, M 2019, ' Co-existing colloidal phases of human duodenal aspirates : Intraindividual fluctuations and interindividual variability in relation to molecular composition ', Journal of Pharmaceutical and Biomedical Analysis, vol. 170, no. June, pp. 22-29 . https://doi.org/10.1016/j.jpba.2019.03.026
We investigated the ultrastructural pattern of colloidal phases in human duodenal fluids. Aspirates were collected from three volunteers in both fasted and fed nutritional states. Analysis methods comprised the combination of asymmetric flow field-fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a71fe8e54c0a5b7be39e698ec932b9
https://doi.org/10.1016/j.jpba.2019.03.026
https://doi.org/10.1016/j.jpba.2019.03.026
Autor:
Jan Tack, Hanne Vanheel, Johan D. Söderholm, Tim Vanuytsel, Ricard Farré, Dorien Beeckmans, Danny Riethorst, Åsa V. Keita, Patrick Augustijns
Publikováno v:
Neurogastroenterology & Motility. 32
BACKGROUND: Functional dyspepsia (FD) is a complex disorder, in which multiple mechanisms underlie symptom generation, including impaired duodenal barrier function. Moreover, an altered duodenal bile salt pool was recently discovered in patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435c41c971f4ffb1acb330a7952b83ee
https://doi.org/10.1111/nmo.13788
https://doi.org/10.1111/nmo.13788
Publikováno v:
European Journal of Pharmaceutical Sciences. 121:338-346
Intestinal permeability assessment is an important aspect of drug development, which strongly depends on the solvent system used in the intestinal donor compartment. For this purpose, human intestinal fluids (HIF) can be considered as the golden stan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2de5070721d299aff9f9e7a0f01e06
https://doi.org/10.1016/j.ejps.2018.06.007
https://doi.org/10.1016/j.ejps.2018.06.007
Autor:
Erwin Adams, Jan Tack, Jari Rubbens, Danny Riethorst, Patrick Augustijns, Kris Wolfs, Joachim Brouwers
Publikováno v:
BASE-Bielefeld Academic Search Engine
This study determined intraluminal ethanol concentrations (stomach and duodenum) in fed healthy volunteers after the consumption of common alcoholic beverages (beer, wine, and whisky). The results of this study were compared with a previous study in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd11a16362b5ee35b6c1a5aa3362cb28
https://doi.org/10.1021/acs.molpharmaceut.7b00252
https://doi.org/10.1021/acs.molpharmaceut.7b00252
Publikováno v:
Journal of Pharmaceutical Sciences. 105:673-681
This work provides an elaborate characterization of human intestinal fluids (HIF) collected in fasted- and fed-state conditions. HIF from 20 healthy volunteers (10 M/F) were aspirated by intubation near the ligament of Treitz in a time-dependent mann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdb2fde4ab51d35a6422da5925e0d81
https://doi.org/10.1002/jps.24603
https://doi.org/10.1002/jps.24603
Autor:
Patrick Augustijns, Tim Vanuytsel, Ricard Farré, Dorien Beeckmans, Danny Riethorst, Hanne Vanheel, Jan Tack
Publikováno v:
United European gastroenterology journal. 6(9)
BACKGROUND: Functional dyspepsia is a common functional gastrointestinal disorder in which a variety of pathophysiological mechanisms such as increased intestinal permeability and low-grade inflammation are involved. The factor causing these alterati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf49214d48ac1c25e5a90d3fc227dbe
https://pubmed.ncbi.nlm.nih.gov/30386607
https://pubmed.ncbi.nlm.nih.gov/30386607
Autor:
Patrick Augustijns, Jan Tack, Joachim Brouwers, Amitava Mitra, Filippos Kesisoglou, Danny Riethorst, Wei Xu
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 129
In addition to individual intestinal fluid components, colloidal structures are responsible for enhancing the solubility of lipophilic compounds. The present study investigated the link between the ultrastructure of fed state human intestinal fluids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb1bdfeb77f11b1e60cc32f82ca75b2
https://pubmed.ncbi.nlm.nih.gov/29802985
https://pubmed.ncbi.nlm.nih.gov/29802985
Autor:
Pieter Baatsen, Joachim Brouwers, Danny Riethorst, Jan Tack, Amitava Mitra, Patrick Augustijns, Caroline Remijn
Publikováno v:
Molecular pharmaceutics. 13(10)
Intestinal fluids dictate the intraluminal environment, and therefore, they substantially affect the absorption of orally taken drugs. The characterization of human intestinal fluids (HIF) and the design of simulated intestinal fluids (SIF) mainly fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d71a5b1cb52f16c3a14f35aa3f0d23
https://pubmed.ncbi.nlm.nih.gov/27576295
https://pubmed.ncbi.nlm.nih.gov/27576295
Autor:
Pieter Annaert, Danny Riethorst, Patrick Augustijns, Benjamin Wuyts, Jan Tack, Joachim Brouwers
Publikováno v:
International journal of pharmaceutics. 478(2)
The Ussing chambers model is almost exclusively used in the presence of plain aqueous phosphate buffers as solvent system. In an attempt to further elucidate the effect of luminal ingredients and postprandial conditions on intestinal permeability, po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41dbc9c3073d6d40e20c23b2a75d755b
https://pubmed.ncbi.nlm.nih.gov/25510602
https://pubmed.ncbi.nlm.nih.gov/25510602