Zobrazeno 1 - 10
of 350
pro vyhledávání: '"Danny R. Welch"'
Autor:
Lanjing Wei, Qi Zhang, Cuncong Zhong, Lily He, Yuxia Zhang, Ahlam M. Armaly, Jeffrey Aubé, Danny R. Welch, Liang Xu, Xiaoqing Wu
Publikováno v:
Molecular Oncology, Vol 17, Iss 10, Pp 1962-1980 (2023)
Chemotherapy remains the standard treatment for triple‐negative breast cancer (TNBC); however, chemoresistance compromises its efficacy. The RNA‐binding protein Hu antigen R (HuR) could be a potential therapeutic target to enhance the chemotherap
Externí odkaz:
https://doaj.org/article/7a76c1ec594e40d5afc47174dc9034a1
Autor:
Hung-Ching Chang, Antony M. Gitau, Siri Kothapalli, Danny R. Welch, Mihaela E. Sardiu, Matthew D. McCoy
Publikováno v:
Frontiers in Artificial Intelligence, Vol 6 (2023)
Digital twins are made of a real-world component where data is measured and a virtual component where those measurements are used to parameterize computational models. There is growing interest in applying digital twins-based approaches to optimize p
Externí odkaz:
https://doaj.org/article/8595adcc771343a584ab0e7dd4294715
Autor:
Nanda Kumar Yellapu, Thuc Ly, Mihaela E. Sardiu, Dong Pei, Danny R. Welch, Jeffery A. Thompson, Devin C. Koestler
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-21 (2022)
Abstract Background Triple-negative breast cancer (TNBC) constitutes 10–20% of breast cancers and is challenging to treat due to a lack of effective targeted therapies. Previous studies in TNBC cell lines showed in vitro growth inhibition when JQ1
Externí odkaz:
https://doaj.org/article/3da65822246f449bbbb96ccddf40516a
Autor:
Sudhakiranmayi Kuravi, Riley W. Baker, Muhammad Umair Mushtaq, Irfan Saadi, Tara L. Lin, Carolyn J. Vivian, Anusha Valluripalli, Sunil Abhyankar, Siddhartha Ganguly, Wei Cui, Kojo S. J. Elenitoba-Johnson, Danny R. Welch, Roy A. Jensen, Yogen Saunthararajah, Joseph P. McGuirk, Ramesh Balusu
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-10 (2022)
Abstract Gene fusions are known to drive many human cancers. Therefore, the functional characterization of newly discovered fusions is critical to understanding the oncobiology of these tumors and to enable therapeutic development. NPM1–TYK2 is a n
Externí odkaz:
https://doaj.org/article/b4873855e16f47889db03427bbf1bff8
Autor:
Rosalyn C. Zimmermann, Mihaela E. Sardiu, Christa A. Manton, Md. Sayem Miah, Charles A. S. Banks, Mark K. Adams, Devin C. Koestler, Douglas R. Hurst, Mick D. Edmonds, Michael P. Washburn, Danny R. Welch
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Breast Cancer Metastasis Suppressor 1 (BRMS1) expression is associated with longer patient survival in multiple cancer types. Understanding BRMS1 functionality will provide insights into both mechanism of action and will enhance potential therapeutic
Externí odkaz:
https://doaj.org/article/66f4e69019a44e34bc00a4bed0277ef7
Autor:
Ravshan Burikhanov, Nikhil Hebbar, Sunil K. Noothi, Nidhi Shukla, James Sledziona, Nathália Araujo, Meghana Kudrimoti, Qing Jun Wang, David S. Watt, Danny R. Welch, Jodi Maranchie, Akihiro Harada, Vivek M. Rangnekar
Publikováno v:
Cell Reports, Vol 18, Iss 2, Pp 508-519 (2017)
Summary: The induction of tumor suppressor proteins capable of cancer cell apoptosis represents an attractive option for the re-purposing of existing drugs. We report that the anti-malarial drug, chloroquine (CQ), is a robust inducer of Par-4 secreti
Externí odkaz:
https://doaj.org/article/3ebeceb7b56a457eb08f0dec28efe808
Autor:
Jennifer C. Kasemeier-Kulesa, Morgan H. Romine, Jason A. Morrison, Caleb M. Bailey, Danny R. Welch, Paul M. Kulesa
Publikováno v:
Biology Open, Vol 7, Iss 1 (2018)
Melanoma pathogenesis from normal neural crest-derived melanocytes is often fatal due to aggressive cell invasion throughout the body. The identification of signals that reprogram de-differentiated, metastatic melanoma cells to a less aggressive and
Externí odkaz:
https://doaj.org/article/e0939d5a61be422197aa0ffe3af04e1e
Publikováno v:
Chinese Journal of Lung Cancer, Vol 13, Iss 2, Pp 140-143 (2010)
Externí odkaz:
https://doaj.org/article/9204b38778944b999f0af278b270b1a7
Publikováno v:
BioTechniques, Vol 33, Iss 6, Pp 1197-1200 (2002)
Externí odkaz:
https://doaj.org/article/ae85933b1f684f739acf77453606e504
Publikováno v:
Cancer Research. 83:P1-13
The 5-year relative survival rate for triple-negative breast cancer (TNBC) is 77%, which is notably lower than 90%, the overall survival rate for breast cancer. The primary systemic treatment for TNBC remains to be chemotherapy. However, patients fre