Zobrazeno 1 - 10
of 523
pro vyhledávání: '"Danny R. Welch"'
Publikováno v:
The Quarterly Review of Biology, 2012 Sep . 87(3), 277-277.
Externí odkaz:
https://www.jstor.org/stable/10.1086/666822
Autor:
Lanjing Wei, Qi Zhang, Cuncong Zhong, Lily He, Yuxia Zhang, Ahlam M. Armaly, Jeffrey Aubé, Danny R. Welch, Liang Xu, Xiaoqing Wu
Publikováno v:
Molecular Oncology, Vol 17, Iss 10, Pp 1962-1980 (2023)
Chemotherapy remains the standard treatment for triple‐negative breast cancer (TNBC); however, chemoresistance compromises its efficacy. The RNA‐binding protein Hu antigen R (HuR) could be a potential therapeutic target to enhance the chemotherap
Externí odkaz:
https://doaj.org/article/7a76c1ec594e40d5afc47174dc9034a1
Autor:
Hung-Ching Chang, Antony M. Gitau, Siri Kothapalli, Danny R. Welch, Mihaela E. Sardiu, Matthew D. McCoy
Publikováno v:
Frontiers in Artificial Intelligence, Vol 6 (2023)
Digital twins are made of a real-world component where data is measured and a virtual component where those measurements are used to parameterize computational models. There is growing interest in applying digital twins-based approaches to optimize p
Externí odkaz:
https://doaj.org/article/8595adcc771343a584ab0e7dd4294715
Autor:
Nanda Kumar Yellapu, Thuc Ly, Mihaela E. Sardiu, Dong Pei, Danny R. Welch, Jeffery A. Thompson, Devin C. Koestler
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-21 (2022)
Abstract Background Triple-negative breast cancer (TNBC) constitutes 10–20% of breast cancers and is challenging to treat due to a lack of effective targeted therapies. Previous studies in TNBC cell lines showed in vitro growth inhibition when JQ1
Externí odkaz:
https://doaj.org/article/3da65822246f449bbbb96ccddf40516a
Autor:
Sudhakiranmayi Kuravi, Riley W. Baker, Muhammad Umair Mushtaq, Irfan Saadi, Tara L. Lin, Carolyn J. Vivian, Anusha Valluripalli, Sunil Abhyankar, Siddhartha Ganguly, Wei Cui, Kojo S. J. Elenitoba-Johnson, Danny R. Welch, Roy A. Jensen, Yogen Saunthararajah, Joseph P. McGuirk, Ramesh Balusu
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-10 (2022)
Abstract Gene fusions are known to drive many human cancers. Therefore, the functional characterization of newly discovered fusions is critical to understanding the oncobiology of these tumors and to enable therapeutic development. NPM1–TYK2 is a n
Externí odkaz:
https://doaj.org/article/b4873855e16f47889db03427bbf1bff8
Publikováno v:
Cancer Research. 83:P1-13
The 5-year relative survival rate for triple-negative breast cancer (TNBC) is 77%, which is notably lower than 90%, the overall survival rate for breast cancer. The primary systemic treatment for TNBC remains to be chemotherapy. However, patients fre
Autor:
Rosalyn C. Zimmermann, Mihaela E. Sardiu, Christa A. Manton, Md. Sayem Miah, Charles A. S. Banks, Mark K. Adams, Devin C. Koestler, Douglas R. Hurst, Mick D. Edmonds, Michael P. Washburn, Danny R. Welch
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Breast Cancer Metastasis Suppressor 1 (BRMS1) expression is associated with longer patient survival in multiple cancer types. Understanding BRMS1 functionality will provide insights into both mechanism of action and will enhance potential therapeutic
Externí odkaz:
https://doaj.org/article/66f4e69019a44e34bc00a4bed0277ef7
Publikováno v:
Trends in Cancer. 8:1002-1018
The contributions of mitochondria to cancer have been recognized for decades. However, the focus on the metabolic role of mitochondria and the diminutive size of the mitochondrial genome compared to the nuclear genome have hindered discovery of the r
Autor:
Ravshan Burikhanov, Nikhil Hebbar, Sunil K. Noothi, Nidhi Shukla, James Sledziona, Nathália Araujo, Meghana Kudrimoti, Qing Jun Wang, David S. Watt, Danny R. Welch, Jodi Maranchie, Akihiro Harada, Vivek M. Rangnekar
Publikováno v:
Cell Reports, Vol 18, Iss 2, Pp 508-519 (2017)
Summary: The induction of tumor suppressor proteins capable of cancer cell apoptosis represents an attractive option for the re-purposing of existing drugs. We report that the anti-malarial drug, chloroquine (CQ), is a robust inducer of Par-4 secreti
Externí odkaz:
https://doaj.org/article/3ebeceb7b56a457eb08f0dec28efe808
Autor:
Shrikant Anant, Roy A. Jensen, Danny R. Welch, Vibhudutta Awasthi, Shahid Umar, Animesh Dhar, Nathan D. Nicholes, Dharmalingam Subramaniam
Dysregulated Notch signaling plays an important role in the progression of cancer. Notch signaling affects tumor growth and angiogenesis through the actions of its ligand Jagged-1. In this study, we developed a novel compound 3,5-bis(2,4-difluorobenz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::024e473434de01a6439dbbaf71d9089f
https://doi.org/10.1158/1535-7163.c.6535339
https://doi.org/10.1158/1535-7163.c.6535339