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Autor:
Alfred R. Crosswell, Karen Leboulluec, Saulnier Mark G, Danny P.C. McGee, Dolatrai M. Vyas, Byron H. Long
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1619-1624
The E-ring 3′,4′,5′-trihydroxy etoposide analog 3 of the clinical antitumor agent etoposide 1 was synthesized from the corresponding etoposide ortho-quinone 2 . This analog is twice as potent as etoposide in its ability to elicit topoisomerase