Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Danny Ortuno"'
Autor:
Kristin Taborn, Joseph Ligutti, Josie H. Lee, Thomas Kornecook, Dong Liu, Dawn Zhu, Stephen Altmann, Ruoyuan Yin, Xuhai Be, Robert T. Fremeau, Jinti Wang, John Roberts, David J. Matson, Danielle Johnson, Violeta Yu, Christopher P Ilch, Bryan D. Moyer, Jason A. Luther, Virginia Berry, Matthew Weiss, Danny Ortuno, Michael Jarosh, Sonya G. Lehto
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 362:146-160
Potent and selective antagonists of the voltage-gated sodium channel NaV1.7 represent a promising avenue for the development of new chronic pain therapies. We generated a small molecule atropisomer quinolone sulfonamide antagonist AMG8379 and a less
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d863f2d2c28cbf4708d06dfd96734ade
https://doi.org/10.1124/jpet.116.239590
https://doi.org/10.1124/jpet.116.239590
Autor:
Dana Nojima, Ming Huang, Holly J. Carlisle, Songli Wang, Qingwen Cheng, Danny Ortuno, Paul D. Kassner, Michael Ollmann, Christopher M. Hale
Publikováno v:
Autophagy. 12:713-726
Autophagy is the primary process for recycling cellular constituents through lysosomal degradation. In addition to nonselective autophagic engulfment of cytoplasm, autophagosomes can recognize specific cargo by interacting with ubiquitin-binding auto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f690950968261170f880cd1e476bbd6
https://doi.org/10.1080/15548627.2016.1147669
https://doi.org/10.1080/15548627.2016.1147669
Autor:
Peter I. Dosa, Yunqing Shi, Bradley Teegarden, Hussien A. Al-Shamma, Dominic P. Behan, John W. Adams, Michael Morgan, Jeremy G. Richman, William Thomsen, Daniel T. Connolly, Juan Ramirez, Danny Ortuno
Publikováno v:
European Journal of Pharmacology. 586:234-243
We have evaluated the anti-platelet and vascular pharmacology of AR246686, a novel 5-hydroxytryptamine2A (5-HT2A) receptor antagonist. AR246686 displayed high affinity binding to membranes of HEK cells stably expressing recombinant human and rat 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe1cc907ef4cb76ec4b2a20df224a97
https://doi.org/10.1016/j.ejphar.2007.11.056
https://doi.org/10.1016/j.ejphar.2007.11.056