Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Danny N Dhanasekaran"'
Autor:
Camille C Gunderson, Rangasudhagar Radhakrishnan, Rohini Gomathinayagam, Sanam Husain, Sheeja Aravindan, Kathleen M Moore, Danny N Dhanasekaran, Muralidharan Jayaraman
Publikováno v:
Biomarker Insights, Vol 17 (2022)
Clinical management of gynecological cancer begins by optimal debulking with first-line platinum-based chemotherapy. However, in ~80% patients, ovarian cancer will recur and is lethal. Prognostic gene signature panel identifying platinum-resistance e
Externí odkaz:
https://doaj.org/article/0780ba611363457ba4faf1e929ea766e
Autor:
Se Ik Kim, Sangick Park, Eunyong Ahn, Jeunhui Kim, HyunA Jo, Juwon Lee, Untack Cho, Maria Lee, Cheol Lee, Danny N. Dhanasekaran, Taejin Ahn, Yong Sang Song
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 9, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/bf77184b3a2644eb808f39c83c96039f
Autor:
Alessandra Ferraresi, Carlo Girone, Chinmay Maheshwari, Letizia Vallino, Danny N. Dhanasekaran, Ciro Isidoro
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5691 (2024)
One aspect of ovarian tumorigenesis which is still poorly understood is the tumor–stroma interaction, which plays a major role in chemoresistance and tumor progression. Cancer-associated fibroblasts (CAFs), the most abundant stromal cell type in th
Externí odkaz:
https://doaj.org/article/41d32967b8c24d3eb9196a6831e1a0cb
Autor:
Revathy Nadhan, Srishti Kashyap, Ji Hee Ha, Muralidharan Jayaraman, Yong Sang Song, Ciro Isidoro, Danny N. Dhanasekaran
Publikováno v:
Metabolites, Vol 13, Iss 5, p 618 (2023)
Peritoneal cancers present significant clinical challenges with poor prognosis. Understanding the role of cancer cell metabolism and cancer-promoting metabolites in peritoneal cancers can provide new insights into the mechanisms that drive tumor prog
Externí odkaz:
https://doaj.org/article/d165b9bb6e864f95b7fa78992c7f3bc4
Autor:
Chiara Vidoni, Alessandra Ferraresi, Letizia Vallino, Amreen Salwa, Ji Hee Ha, Christian Seca, Beatrice Garavaglia, Danny N. Dhanasekaran, Ciro Isidoro
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1723 (2023)
Cancer cells drive the glycolytic process towards the fermentation of pyruvate into lactate even in the presence of oxygen and functioning mitochondria, a phenomenon known as the “Warburg effect”. Although not energetically efficient, glycolysis
Externí odkaz:
https://doaj.org/article/d16a041a13b44e7ca469df8b8a8fbd60
Autor:
Feng Yan, Ji-Hee Ha, Yuyang Yan, Sam B. Ton, Chen Wang, Bornface Mutembei, Zaid A. Alhajeri, Aubrey F. McNiel, Andrew J. Keddissi, Qinghao Zhang, Muralidharan Jayaraman, Danny N. Dhanasekaran, Qinggong Tang
Publikováno v:
IEEE Transactions on Biomedical Engineering. 70:1891-1901
Publikováno v:
Cells, Vol 11, Iss 16, p 2517 (2022)
The cellular signaling network involves co-ordinated regulation of numerous signaling molecules that aid the maintenance of cellular as well as organismal homeostasis. Aberrant signaling plays a major role in the pathophysiology of many diseases. Rec
Externí odkaz:
https://doaj.org/article/f1e7614c3ad04625a84a2023a281e1b8
Autor:
Alessandra Ferraresi, Carlo Girone, Andrea Esposito, Chiara Vidoni, Letizia Vallino, Eleonora Secomandi, Danny N. Dhanasekaran, Ciro Isidoro
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Ovarian cancer (OC) is characterized by a high mortality rate due to the late diagnosis and the elevated metastatic potential. Autophagy, a lysosomal-driven catabolic process, contributes to the macromolecular turnover, cell homeostasis, and survival
Externí odkaz:
https://doaj.org/article/94c515a1fb204d79b2d96f5e5ebe0682
Autor:
Ji Hee Ha, Muralidharan Jayaraman, Mingda Yan, Padmaja Dhanasekaran, Ciro Isidoro, Yong Sang Song, Danny N. Dhanasekaran
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1211 (2021)
Increased expression of GNAi2, which encodes the α-subunit of G-protein i2, has been correlated with the late-stage progression of ovarian cancer. GNAi2, also referred to as the proto-oncogene gip2, transduces signals from lysophosphatidic acid (LPA
Externí odkaz:
https://doaj.org/article/a6154921bf9544b4a2200c18592e170c
Autor:
Juwon Lee, Youngjin Han, Wenyu Wang, HyunA Jo, Heeyeon Kim, Soochi Kim, Kyung-Min Yang, Seong-Jin Kim, Danny N. Dhanasekaran, Yong Sang Song
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1107 (2021)
The interaction of immune checkpoint molecules in the tumor microenvironment reduces the anti-tumor immune response by suppressing the recognition of T cells to tumor cells. Immune checkpoint inhibitor (ICI) therapy is emerging as a promising therape
Externí odkaz:
https://doaj.org/article/df77798592a842bc9ef825cff9ef924e