Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Danny M, Hatters"'
Autor:
Dezerae Cox, Danny M. Hatters
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109891- (2024)
Summary: Key to a biologists’ capacity to understand data is the ability to make meaningful conclusions about differences in experimental observations. Typically, data are noisy, and conventional methods rely on replicates to average out noise and
Externí odkaz:
https://doaj.org/article/22a6e954842a42ec861afd9069faf1d0
Publikováno v:
npj Systems Biology and Applications, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract The correct spatio-temporal organization of the proteome is essential for cellular homeostasis. However, a detailed mechanistic understanding of this organization and how it is altered in response to external stimuli in the intact cellular e
Externí odkaz:
https://doaj.org/article/09f89417ee4e4b7c932f5ca781e5ce2d
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Proteomics can define features of proteome foldedness by assessing the reactivity of surface exposed amino acids. Here, the authors show that such exposure patterns yield insight to structural changes in chaperones as they bind to unfolded proteins i
Externí odkaz:
https://doaj.org/article/b70159334a13460591cf7de49bf36bab
Autor:
Farheen Farzana, Malcolm J. McConville, Thibault Renoir, Shanshan Li, Shuai Nie, Harvey Tran, Anthony J. Hannan, Danny M. Hatters, Berin A. Boughton
Publikováno v:
Neurobiology of Disease, Vol 176, Iss , Pp 105933- (2023)
In Huntington's disease (HD), a key pathological feature includes the development of inclusion-bodies of fragments of the mutant huntingtin protein in the neurons of the striatum and hippocampus. To examine the molecular changes associated with inclu
Externí odkaz:
https://doaj.org/article/076bba59de224e7fbf2275e6dd517b20
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0233583 (2020)
Mutations that cause Huntington's Disease involve a polyglutamine (polyQ) sequence expansion beyond 35 repeats in exon 1 of Huntingtin. Intracellular inclusion bodies of mutant Huntingtin protein are a key feature of Huntington's disease brain pathol
Externí odkaz:
https://doaj.org/article/3a2c56c580324d5480cfe8000dc60143
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0233247 (2020)
Poly(glycine-alanine) (polyGA) is one of the polydipeptides expressed in Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 1 caused by C9ORF72 mutations and accumulates as inclusion bodies in the brain of patients. Superficially these incl
Externí odkaz:
https://doaj.org/article/222a64ca8528418fb916455da86fa719
Autor:
Lorena Hidalgo San Jose, Mary Jean Sunshine, Christopher H. Dillingham, Bernadette A. Chua, Miriama Kruta, Yuning Hong, Danny M. Hatters, Robert A.J. Signer
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 69-80.e6 (2020)
Summary: Low protein synthesis is a feature of somatic stem cells that promotes regeneration in multiple tissues. Modest increases in protein synthesis impair stem cell function, but the mechanisms by which this occurs are largely unknown. We determi
Externí odkaz:
https://doaj.org/article/a1e642bc95c44510b2cb20474eabe20d
Autor:
Rebecca J. Wood, Angelique R. Ormsby, Mona Radwan, Dezerae Cox, Abhishek Sharma, Tobias Vöpel, Simon Ebbinghaus, Mikael Oliveberg, Gavin E. Reid, Alex Dickson, Danny M. Hatters
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
A pool of quality control proteins (QC) maintains the protein-folding homeostasis in the cell, but its quantitative analysis is challenging. Here the authors develop a FRET sensor based on the protein barnase, able to quantify QC holdase activity and
Externí odkaz:
https://doaj.org/article/6391112b918e4b36a3854c8ea904fe80
Autor:
Moore Z. Chen, Nagaraj S. Moily, Jessica L. Bridgford, Rebecca J. Wood, Mona Radwan, Trevor A. Smith, Zhegang Song, Ben Zhong Tang, Leann Tilley, Xiaohong Xu, Gavin E. Reid, Mahmoud A. Pouladi, Yuning Hong, Danny M. Hatters
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Proteostasis is maintained through a number of molecular mechanisms, some of which function to protect the folded state of proteins. Here the authors demonstrate the use of TPE-MI in a fluorigenic dye assay for the quantitation of unfolded proteins t
Externí odkaz:
https://doaj.org/article/a4333004f228480fbf7846ca619a3233
Autor:
Yasmin M. Ramdzan, Mikhail M. Trubetskov, Angelique R. Ormsby, Estella A. Newcombe, Xiaojing Sui, Mark J. Tobin, Marie N. Bongiovanni, Sally L. Gras, Grant Dewson, Jason M.L. Miller, Steven Finkbeiner, Nagaraj S. Moily, Jonathan Niclis, Clare L. Parish, Anthony W. Purcell, Michael J. Baker, Jacqueline A. Wilce, Saboora Waris, Diana Stojanovski, Till Böcking, Ching-Seng Ang, David B. Ascher, Gavin E. Reid, Danny M. Hatters
Publikováno v:
Cell Reports, Vol 19, Iss 5, Pp 919-927 (2017)
Summary: Competing models exist in the literature for the relationship between mutant Huntingtin exon 1 (Httex1) inclusion formation and toxicity. In one, inclusions are adaptive by sequestering the proteotoxicity of soluble Httex1. In the other, inc
Externí odkaz:
https://doaj.org/article/a88e3936e1a84e4ebc9bd6f66ea0df8a