Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Danny Legge"'
Autor:
Caroline Bull, Emma Hazelwood, Joshua A Bell, Vanessa Tan, Andrei-Emil Constantinescu, Carolina Borges, Danny Legge, Kimberley Burrows, Jeroen R Huyghe, Hermann Brenner, Sergi Castellvi-Bel, Andrew T Chan, Sun-Seog Kweon, Loic Le Marchand, Li Li, Iona Cheng, Rish K Pai, Jane C Figueiredo, Neil Murphy, Marc J Gunter, Nicholas J Timpson, Emma E Vincent
Publikováno v:
eLife, Vol 12 (2023)
Background: Recognizing the early signs of cancer risk is vital for informing prevention, early detection, and survival. Methods: To investigate whether changes in circulating metabolites characterize the early stages of colorectal cancer (CRC) devel
Externí odkaz:
https://doaj.org/article/0ffb1e6001ab4bd0a21592a96abed076
Autor:
Sandra Montes-Olivas, Danny Legge, Abbie Lund, Alexander G Fletcher, Ann C Williams, Lucia Marucci, Martin Homer
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 8, p e1011386 (2023)
Organoids offer a powerful model to study cellular self-organisation, the growth of specific tissue morphologies in-vitro, and to assess potential medical therapies. However, the intrinsic mechanisms of these systems are not entirely understood yet,
Externí odkaz:
https://doaj.org/article/bc64428b884d4479a8b56223f15161f1
Autor:
Mark Gormley, Tom Dudding, Steven J Thomas, Jessica Tyrrell, Andrew R Ness, Miranda Pring, Danny Legge, George Davey Smith, Rebecca C Richmond, Emma E Vincent, Caroline Bull
Publikováno v:
eLife, Vol 12 (2023)
A recent World Health Organization report states that at least 40% of all cancer cases may be preventable, with smoking, alcohol consumption, and obesity identified as three of the most important modifiable lifestyle factors. Given the significant de
Externí odkaz:
https://doaj.org/article/84d346a026074e03b51ebc14cd603507
Autor:
Danny Legge, Ling Li, Whei Moriarty, David Lee, Marianna Szemes, Asef Zahed, Leonidas Panousopoulos, Wan Yun Chung, Yara Aghabi, Jasmin Barratt, Richard Williams, Kathy Pritchard‐Jones, Karim T.A. Malik, Sebastian Oltean, Keith W. Brown
Publikováno v:
Molecular Oncology, Vol 16, Iss 3, Pp 630-647 (2022)
Wilms tumour (WT), an embryonal kidney cancer, has been extensively characterised for genetic and epigenetic alterations, but a proportion of WTs still lack identifiable abnormalities. To uncover DNA methylation changes critical for WT pathogenesis,
Externí odkaz:
https://doaj.org/article/4fdb93ca44e444e2810400925199bb7a
Autor:
Mark Gormley, James Yarmolinsky, Tom Dudding, Kimberley Burrows, Richard M Martin, Steven Thomas, Jessica Tyrrell, Paul Brennan, Miranda Pring, Stefania Boccia, Andrew F Olshan, Brenda Diergaarde, Rayjean J Hung, Geoffrey Liu, Danny Legge, Eloiza H Tajara, Patricia Severino, Martin Lacko, Andrew R Ness, George Davey Smith, Emma E Vincent, Rebecca C Richmond
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009525 (2021)
Head and neck squamous cell carcinoma (HNSCC), which includes cancers of the oral cavity and oropharynx, is a cause of substantial global morbidity and mortality. Strategies to reduce disease burden include discovery of novel therapies and repurposin
Externí odkaz:
https://doaj.org/article/8b53b97b44d54df6b50de0b3f07e5b92
Autor:
Mark Gormley, Tom Dudding, Steven J Thomas, Jessica Tyrrell, Andrew R Ness, Miranda Pring, Danny Legge, George Davey Smith, Rebecca C Richmond, Emma E Vincent, Caroline Bull
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e0c6426fddd635ed9c114d065bbb247
https://doi.org/10.7554/elife.82674.sa2
https://doi.org/10.7554/elife.82674.sa2
Autor:
Marianna Szemes, Danny Legge, Karim Malik, Wan Yun Chung, David A. Lee, Richard D. Williams, Whei Moriarty, Sebastian Oltean, Asef Zahed, Kathy Pritchard-Jones, Leonidas Panousopoulos, Keith W. Brown, Jasmin Barratt, Ling Li, Yara Aghabi
Publikováno v:
Molecular Oncology, Vol 16, Iss 3, Pp 630-647 (2022)
Legge, D N, Moriarty, W F, Lee, D A, Szemes, M, Zahed, A, Panousopoulos, L, Chung, W Y, Aghabi, Y, Barratt, J, Williams, R, Pritchard-Jones, K, Malik, K T A, Oltean, S & Brown, K W 2021, ' The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor ', Molecular Oncology . https://doi.org/10.1002/1878-0261.13101
Molecular Oncology
Legge, D N, Moriarty, W F, Lee, D A, Szemes, M, Zahed, A, Panousopoulos, L, Chung, W Y, Aghabi, Y, Barratt, J, Williams, R, Pritchard-Jones, K, Malik, K T A, Oltean, S & Brown, K W 2021, ' The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor ', Molecular Oncology . https://doi.org/10.1002/1878-0261.13101
Molecular Oncology
Wilms tumour (WT), an embryonal kidney cancer, has been extensively characterised for genetic and epigenetic alterations, but a proportion of WTs still lack identifiable abnormalities. To uncover DNA methylation changes critical for WT pathogenesis,
Autor:
Sandra Montes-Olivas, Danny Legge, Abbie Lund, Alexander G. Fletcher, Ann C. Williams, Lucia Marucci, Martin Homer
Organoids offer a powerful model to study cellular self-organisation, the growth of specific tissue morphologiesin-vitro, and to assess potential medical therapies. However, the intrinsic mechanisms of these systems are not entirely understood yet, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79c2465167792f8490c255d96ffdd069
https://doi.org/10.1101/2022.12.08.519603
https://doi.org/10.1101/2022.12.08.519603
Autor:
Danny Legge, Amy K Holt, Caroline J Bull, Tracey Collard, Madhu Kollareddy, Jake Bellamy, Sarah Groves, Eric H Ma, Emma Hazelwood, David Qualtrough, Borko Amulic, Karim Malik, Ann C Williams, Nicholas Jones, Emma E Vincent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7d5e5c0b2d28216b4d280f61f900cc7
https://doi.org/10.15252/rc.2022178417
https://doi.org/10.15252/rc.2022178417
Autor:
Mark Gormley, Tom Dudding, Steven J Thomas, Jessica Tyrrell, Andrew R Ness, Miranda Pring, Danny Legge, George Davey Smith, Rebecca C Richmond, Emma E Vincent, Caroline Bull
A recent World Health Organization report states that at least 40% of all cancer cases may be preventable, with smoking, alcohol consumption, and obesity identified as three of the most important modifiable lifestyle factors. Given the significant de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc0ae64a61b10a76f6c34c81b99d455
https://doi.org/10.1101/2022.08.10.22278617
https://doi.org/10.1101/2022.08.10.22278617