Ubiquitination of CXCR7 controls receptor trafficking.

Autor: Meritxell Canals, Danny J Scholten, Sabrina de Munnik, Mitchell K L Han, Martine J Smit, Rob Leurs

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e34192 (2012)

The chemokine receptor CXCR7 binds CXCL11 and CXCL12 with high affinity, chemokines that were previously thought to bind exclusively to CXCR4 and CXCR3, respectively. Expression of CXCR7 has been associated with cardiac development as well as with tu

Externí odkaz: https://doaj.org/article/7a20179af6284c509d08af9f5b2ad276

Practical Guidelines to Redesign Introductory Chemistry Courses Using a Flexible and Adaptive Blended Format

Autor: Hanna Westbroek, Marco Siderius, Danny J. Scholten, Erik J. J. Boon, Stefan J. Dekker, Jacqueline E. van Muijlwijk-Koezen, J. Chris Vos, Anna H. Vuuregge, Maikel Wijtmans

Publikováno v: Scholten, D J, Wijtmans, M, Dekker, S J, Vuuregge, A H, Boon, E J J, Vos, J C, Siderius, M, Westbroek, H & Van Muijlwijk-Koezen, J E 2021, ' Practical Guidelines to Redesign Introductory Chemistry Courses Using a Flexible and Adaptive Blended Format ', Journal of Chemical Education, vol. 98, no. 12, pp. 3852-3863 . https://doi.org/10.1021/acs.jchemed.1c00644
Journal of Chemical Education, 98(12), 3852-3863. American Chemical Society

Incorporation of increased flexibility and adaptivity in courses can support freshmen with taking responsibility for their learning process. This is especially beneficial in the case of chemistry courses given their typically abstract nature and asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbb8185d5ffb1cc5fc4a52d8fe0f3cb
https://doi.org/10.1021/acs.jchemed.1c00644

Metabolic profiling of ligands for the chemokine receptor CXCR3 by liquid chromatography-mass spectrometry coupled to bioaffinity assessment

Autor: David Falck, Maikel Wijtmans, Martine J. Smit, Rob Leurs, Jeroen Kool, Danny J. Scholten, Marija Mladic, Wilfried M. A. Niessen

Publikováno v: Analytical and Bioanalytical Chemistry, 407(23), 7067-81. Analytical and Bioanalytical Chemistry
Mladic, M, Scholten, D J, Wijtmans, M, Falck, D, Leurs, R, Niessen, W M A, Smit, M J & Kool, J 2015, ' Metabolic profiling of ligands for the chemokine receptor CXCR3 by liquid chromatography-mass spectrometry coupled to bioaffinity assessment ', Analytical and Bioanalytical Chemistry, vol. 407, no. 23, pp. 7067-81 . https://doi.org/10.1007/s00216-015-8867-z
Analytical and Bioanalytical Chemistry, 407(23), 7067-7081
Analytical and Bioanalytical Chemistry

Chemokine receptors belong to the class of G protein-coupled receptors and are important in the host defense against infections and inflammation. However, aberrant chemokine signaling is linked to different disorders such as cancer, central nervous s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680602957da63a1aa59f82c4df40b072
https://hdl.handle.net/1871.1/6645112a-8ab2-4805-9f4a-87e5b18543b2

C(X)CR in silico: Computer-aided prediction of chemokine receptor–ligand interactions

Autor: P. de Kruijf, Rob Leurs, Luc Roumen, I.J.P. de Esch, C de Graaf, Danny J. Scholten

Publikováno v: Roumen, L, Scholten, D J, de Kruijf, P, de Esch, I J P, Leurs, R & de Graaf, C 2012, ' C(X)CR in silico: Computer-aided prediction of chemokine receptor-ligand interactions ', Drug Discovery Today, vol. 9, pp. e281-e291 . https://doi.org/10.1016/j.ddtec.2012.05.002
Drug Discovery Today, 9, e281-e291. Elsevier Limited

This review will focus on the construction, refinement, and validation of chemokine receptor models for the purpose of structure-based virtual screening and ligand design. The review will present a comparative analysis of ligand binding pockets in ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba61d5b3ec15a146be4ef36a6584710e
https://doi.org/10.1016/j.ddtec.2012.05.002

Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 bisaryl-type ligands

Autor: Rob Leurs, Iwan J. P. de Esch, Meritxell Canals, Luc Roumen, Danny J. Scholten, Marjolein Glas, Chris de Graaf, Martine J. Smit, Frans J. J. de Kanter, Maikel Wijtmans, Hans Custers, Marlies C. A. Vreeker

Publikováno v: Journal of Medicinal Chemistry, 55, 10572-10583. American Chemical Society
Wijtmans, M, Scholten, D J, Roumen, L, Canals, M, Custers, H, Glas, M, Vreeker, M, de Graaf, C, Smit, M J, de Esch, I J P & Leurs, R 2012, ' Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 bisaryl-type ligands ', Journal of Medicinal Chemistry, vol. 55, pp. 10572-10583 . https://doi.org/10.1021/jm301240t

The G protein-coupled chemokine receptor CXCR3 plays a role in numerous inflammatory events. The endogenous ligands for the chemokine receptors are peptides, but in this study we disclose small-molecule ligands that are able to activate CXCR3. A clas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cae94cc4dbc4a7a598c8bf52a8aa88
https://doi.org/10.1021/jm301240t