Výsledky vyhledávání - "Danny Ganame"

Akademický článek

Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign.

Autor: Melissa L Sykes, Jonathan B Baell, Marcel Kaiser, Eric Chatelain, Sarah R Moawad, Danny Ganame, Jean-Robert Ioset, Vicky M Avery

Publikováno v: PLoS Neglected Tropical Diseases, Vol 6, Iss 11, p e1896 (2012)

Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Drugs available for the treatment of HAT have significant issues related to difficult administration regime

Externí odkaz: https://doaj.org/article/89a7928a2afc4ed9b42b742e35074888

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Total Synthesis of the Proposed Structure of 8-Deshydroxyajudazol A: A Modified Approach to 2,4-Disubstituted Oxazoles

Autor: Tim Quach, Mark A. Rizzacasa, Bill C. Hawkins, Danny Ganame, Sebastien Meiries, Stephen L. Birkett

Publikováno v: The Journal of Organic Chemistry. 78:116-123

The total synthesis of the proposed structure for the minor myxobacterial metabolite 8-deshydroxyajudazol A (3) is described. The isochromanone moiety present in the eastern fragment was constructed by an intramolecular-Diels-Alder (IMDA). Difficulti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a1810977998e4eb1dbe3ae0c4d1b8e
https://doi.org/10.1021/jo302055w

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Total Synthesis of (-)-Reveromycin A via a Hetero-Diels-Alder Approach

Autor: Peter A. Tregloan, Danny Ganame, Mark A. Rizzacasa, Mariana El Sous

Publikováno v: Synthesis. 2010:3954-3966

The asymmetric total synthesis of (-)-reveromycin A is described which utilizes a Lewis acid catalyzed inverse electron demand hetero-Diels-Alder reaction followed by hydroboration/oxidation to afford the labile [6,6]-spiroketal core in a highly ster

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5f47960432492a80eecfb242c50ffeb
https://doi.org/10.1055/s-0030-1258308

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Total synthesis of spiroketal containing natural products: kinetic vs. thermodynamic approaches

Autor: Shannon D. Zanatta, Mariana El Sous, Mark A. Rizzacasa, Danny Ganame

Publikováno v: ARKIVOC, Vol 2006, Iss 7, Pp 105-119 (2006)

This review details part of a lecture delivered at the 20 ICHC in Palermo Italy, July 31-August 5 2005. The published total syntheses of reveromycin A (1) and the assigned structure for spirofungin B (26) are described. The approach to 1 utilized a h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0425df6b62d06cb8f05f78284ff81baf
https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.0007.710

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Synthesis of the C9–C29 fragments of ajudazols A and B

Autor: Mark A. Rizzacasa, Charlotte Poole, Tim Quach, Danny Ganame

Publikováno v: Tetrahedron Letters. 48:5841-5843

The syntheses of both C9–C29 fragments 3 and 4 of the myxobacteria metabolites ajudazols A ( 1 ) and B ( 2 ) are described. The key steps were a cyclodehydration to form the oxazole, Sonogashira coupling to form the C18–C19 bond and a P-2 Ni medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80a911473ed3697c67bded338377953d
https://doi.org/10.1016/j.tetlet.2007.06.072

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