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Paclitaxel Inhibits KCNQ Channels in Primary Sensory Neurons to Initiate the Development of Painful Peripheral Neuropathy

Autor: Zizhen Wu, Gabor Toro, Guoying Xu, Danny Dang, Charmaine Prater, Qing Yang

Publikováno v: Cells, Vol 11, Iss 24, p 4067 (2022)

Cancer patients undergoing paclitaxel infusion usually experience peripheral nerve degeneration and serious neuropathic pain termed paclitaxel-induced peripheral neuropathy (PIPN). However, alterations in the dose or treatment schedule for paclitaxel

Externí odkaz: https://doaj.org/article/949c67700d8249f88a8b519d6c33976c

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Enhancing KCNQ Channel Activity Improves Neurobehavioral Recovery after Spinal Cord Injury

Autor: Guoying Xu, Danny Dang, Zizhen Wu, Lin Li, Fuhua Xie, Qing Yang

Publikováno v: J Pharmacol Exp Ther

Spinal cord injury (SCI) usually leads to acute neuronal death and delayed secondary degeneration, resulting in sensory dysfunction, paralysis, and chronic pain. Excessive excitation is one of the critical factors leading to secondary neural damage i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ee192150621d8a8b71d0940375933b
https://pubmed.ncbi.nlm.nih.gov/31969383

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