Monitoring response to anti-angiogenic mTOR inhibitor therapy in vivo using 111In-bevacizumab

Autor: Neel Patel, Sarah Able, Danny Allen, Emmanouil Fokas, Bart Cornelissen, Fergus V. Gleeson, Adrian L. Harris, Katherine A. Vallis

Publikováno v: EJNMMI Research, Vol 7, Iss 1, Pp 1-9 (2017)

Abstract Background The ability to image vascular endothelial growth factor (VEGF) could enable prospective, non-invasive monitoring of patients receiving anti-angiogenic therapy. This study investigates the specificity and pharmacokinetics of 111In-

Externí odkaz: https://doaj.org/article/3bfeae30219c45a4bc3f60a8faef9009

A System-Agnostic, Adaptable and Extensible Animal Support Cradle System for Cardio-Respiratory-Synchronised, and Other, Multi-Modal Imaging of Small Animals

Autor: Veerle Kersemans, Stuart Gilchrist, Philip Danny Allen, Sheena Wallington, Paul Kinchesh, John Prentice, Martin Tweedie, Jamie H. Warner, Sean C. Smart

Publikováno v: Tomography, Vol 7, Iss 1, Pp 39-54 (2021)

Standardisation of animal handling procedures for a wide range of preclinical imaging scanners will improve imaging performance and reproducibility of scientific data. Whilst there has been significant effort in defining how well scanners should oper

Externí odkaz: https://doaj.org/article/3fc158c941f949b28b6b95cbb43029c6

Data from 89Zr-anti-γH2AX-TAT but not 18F-FDG Allows Early Monitoring of Response to Chemotherapy in a Mouse Model of Pancreatic Ductal Adenocarcinoma

Autor: Bart Cornelissen, Eric O'Neill, Somnath Mukherjee, P. Danny Allen, Veerle Kersemans, Luisa Contreras Bravo, Michael J. Mosley, James C. Knight

Purpose: Late-stage, unresectable pancreatic ductal adenocarcinoma (PDAC) is largely resistant to chemotherapy and consequently has a very poor 5-year survival rate of 89Zr-anti-γH2AX-TAT, to monitor DNA damage in response to fluorouracil (5-FU), ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155142651d80d1891da85e28a29a0470
https://doi.org/10.1158/1078-0432.c.6527135

A simple, open and extensible gating Control unit for cardiac and respiratory synchronisation control in small animal MRI and demonstration of its robust performance in steady-state maintained CINE-MRI

Autor: John S. Beech, Jack J. Miller, Veerle Kersemans, Danny Allen, Jürgen E. Schneider, Stuart Gilchrist, Borivoj Vojnovic, Paul Kinchesh, Sean Smart, Michael Brady

Publikováno v: Magnetic Resonance Imaging

Prospective cardiac gating during MRI is hampered by electromagnetic induction from the rapidly switched imaging gradients into the ECG detection circuit. This is particularly challenging in small animal MRI, as higher heart rates combined with a sma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7995b153e23f13fb92cfa35eec3a14e2
http://europepmc.org/articles/PMC8274699

Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer

Autor: Danny Allen, Stephen J. Lockett, Ruth J. Muschel, Tamar Yechezkel, Paul Kinchesh, Boris Vojnovic, Alastair D. Lamb, Hanna T. Sjoberg, Dina Preise, Richard J. Bryant, Jens Rittscher, Ka Ho Tam, Adrian L. Harris, Ian G. Mills, Yiannis Philippou, Anette L Magnussen, Iain D. C. Tullis, Emma A Murphy, Lilach Agemy, Freddie C. Hamdy, David A. Wink, Andrea Chatrian, Avigdor Scherz, Sean Smart, Joël Lefebvre, Stuart Gilchrist, Esther Bridges, David A. Scheiblin

Publikováno v: Sjoberg, H T, Philippou, Y, Magnussen, A L, Tullis, I D C, Bridges, E, Chatrian, A, Lefebvre, J, Tam, K H, Murphy, E A, Rittscher, J, Preise, D, Agemy, L, Yechezkel, T, Smart, S C, Kinchesh, P, Gilchrist, S, Allen, D P, Scheiblin, D A, Lockett, S J, Wink, D A, Lamb, A D, Mills, I G, Harris, A, Muschel, R J, Vojnovic, B, Scherz, A, Hamdy, F C & Bryant, R J 2021, ' Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer ', British Journal of Cancer, vol. 125, pp. 534-546 . https://doi.org/10.1038/s41416-021-01450-6
British Journal of Cancer

Background There is a need to improve the treatment of prostate cancer (PCa) and reduce treatment side effects. Vascular-targeted photodynamic therapy (VTP) is a focal therapy for low-risk low-volume localised PCa, which rapidly disrupts targeted tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e332f7007516e12e8126b136968964
https://pure.qub.ac.uk/en/publications/tumour-irradiation-combined-with-vasculartargeted-photodynamic-therapy-enhances-antitumour-effects-in-preclinical-prostate-cancer(a26d16da-6c3f-41e3-84f7-b20bf56280b2).html