Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Danny A. Zwijnenburg"'
Autor:
Leonie Hartl, Marieke S. ten Brink, Hella L. Aberson, Jan Koster, Danny A. Zwijnenburg, JanWillem Duitman, Maarten F. Bijlsma, C. Arnold Spek
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9449 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a dismal disease with a low 5-year survival rate of only 13%. Despite intense research efforts, PDAC remains insufficiently understood. In part, this is attributed to opposing effects of key players being un
Externí odkaz:
https://doaj.org/article/c3b6f80a508d47debd1643a94dbe33ab
Autor:
Mohammed Ghiboub, Jan Koster, Peter D. Craggs, Andrew Y. F. Li Yim, Anthony Shillings, Sue Hutchinson, Ryan P. Bingham, Kelly Gatfield, Ishtu L. Hageman, Gang Yao, Heather P. O’Keefe, Aaron Coffin, Amish Patel, Lisa A. Sloan, Darren J. Mitchell, Thomas G. Hayhow, Laurent Lunven, Robert J. Watson, Christopher E. Blunt, Lee A. Harrison, Gordon Bruton, Umesh Kumar, Natalie Hamer, John R. Spaull, Danny A. Zwijnenburg, Olaf Welting, Theodorus B. M. Hakvoort, Anje A. te Velde, Johan van Limbergen, Peter Henneman, Rab K. Prinjha, Menno P. J. de Winther, Nicola R. Harker, David F. Tough, Wouter J. de Jonge
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-27 (2022)
Abstract Background SP140 is a bromodomain-containing protein expressed predominantly in immune cells. Genetic polymorphisms and epigenetic modifications in the SP140 locus have been linked to Crohn’s disease (CD), suggesting a role in inflammation
Externí odkaz:
https://doaj.org/article/9421aa4ae34c4942a0bffbd856768807
A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
Autor:
Tim van Groningen, Nurdan Akogul, Ellen M. Westerhout, Alvin Chan, Nancy E. Hasselt, Danny A. Zwijnenburg, Marloes Broekmans, Peter Stroeken, Franciska Haneveld, Gerrit K. J. Hooijer, C. Dilara Savci-Heijink, Arjan Lakeman, Richard Volckmann, Peter van Sluis, Linda J. Valentijn, Jan Koster, Rogier Versteeg, Johan van Nes
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Neuroblastoma includes adrenergic and mesenchymal cell types that can interconvert. Here, the authors show that this transdifferentiation is driven by a NOTCH feedforward loop that allows a swift transition between two semi-stable cellular states.
Externí odkaz:
https://doaj.org/article/514276fb271e42e0afc3df43c40d7742
Autor:
Marcel Kool, Rogier Versteeg, Jan Koster, Danny A. Zwijnenburg, Nancy E. Hasselt, Talitha G. de Haas, Jens Bunt
PDF file - 1.4MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abf354014e5d75920f65c1d2a35a6a5
https://doi.org/10.1158/1541-7786.22519308.v1
https://doi.org/10.1158/1541-7786.22519308.v1