Výsledky vyhledávání - "Danny LaFrance"

Development of the Commercial Route for the Manufacture of a 5-Lipoxygenase Inhibitor PF-04191834

Autor: Gerald A. Weisenburger, Brian Patrick Chekal, Janice E. Sieser, Brian C. Vanderplas, David B. Damon, Michael St. Pierre, John G. Van Alsten, Carlos Mojica, Kyle R. Leeman, Danny Lafrance, Carrie Wager, Shu Yu, Rajappa Vaidyanathan, Gregory J. Withbroe, Karen Sutherland, Andrew S. Palm

Publikováno v: Organic Process Research & Development. 19:1944-1953

A de novo three-step-one-pot process for the formation of PF-04191834 was developed. This methodology employed inexpensive, odorless, and readily available commodity chemical iso-octyl-3-mercaptopropionate as a sulfur source, which could be a general

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b86ed2168e64162a477212d79c402d9c
https://doi.org/10.1021/op500412a

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Process Research and Development of an Enantiomerically Enriched Allyic Amine, One of the Key Intermediates for the Manufacture of Synthetic Tetracyclines

Autor: Philip C. Hogan, Olga Gilicky, Zhimin Wang, Magnus Ronn, Danny Lafrance, Chi-Li Chen, John Niu, Wu-Yan Zhang, Nicholas Dunwoody

Publikováno v: Organic Process Research & Development. 19:1784-1795

A robust, cost-effective, and high yielding manufacturing process for enantiomerically enriched (S)-allylic amine 3, a key intermediate for fully synthetic tetracyclines have been developed. Two novel and scalable asymmetric vinylations resulting in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09646552ec175274a3463920d90aac93
https://doi.org/10.1021/acs.oprd.5b00274

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New Synthetic Route to a Dipeptidyl Peptidase-4 Inhibitor

Autor: Stephane Caron, Danny Lafrance

Publikováno v: Organic Process Research & Development. 16:409-414

A new synthetic route to a dipeptidyl peptidase-4 (DPP4) inhibitor was developed and demonstrated on a multigram scale. This approach takes advantage of the cheap and readily available Boc-trans-4-hydroxy-l-proline methyl ester as starting material w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2597fbde59f375cde6c71a6eedb94174
https://doi.org/10.1021/op200309z

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A Novel Iodide-Catalyzed Reduction of Nitroarenes and Aryl Ketones with H3PO2 or H3PO3: Its Application to the Synthesis of a Potential Anticancer Agent

Autor: Danny Lafrance, Scott G. Greene, Ji Xie, Wong Yee-Shing, George G. Wu, Zhijian Liu, Frank Xing Chen

Publikováno v: Organic Letters. 13:5220-5223

A novel iodide-catalyzed reduction method using hypophosphorous and/or phosphorus acids was developed to reduce both diaryl ketones and nitroarenes chemoselectively in the presence of chloro and bromo substituents in high yield. This efficient and pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a9821a48e2961d6e4935cc1763958c
https://doi.org/10.1021/ol102174w

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Mild Decarboxylative Activation of Malonic Acid Derivatives by 1,1′-Carbonyldiimidazole

Autor: Paul Bowles, Robert J. Rafka, Kyle R. Leeman, Danny Lafrance

Publikováno v: Organic Letters. 13:2322-2325

Malonic acid derivatives undergo unusually mild decarboxylation when treated with N,N'-carbonyldiimidazole (CDI) at room temperature to generate the carbonyl imidazole moiety in high yield, which can be reacted further with a variety of nucleophiles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ab090966ae6bf198aad7beb2c22ae1
https://doi.org/10.1021/ol200575c

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Insertion of Imines and Carbon Monoxide into Manganese−Alkyl Bonds: Synthesis and Structure of a Manganese−α-Amino Acid Derivative

Autor: and Rajiv Dhawan, Jason L. Davis, Danny Lafrance, Bruce A. Arndtsen

Publikováno v: Organometallics. 20:1128-1136

Two new routes have been developed to generate manganese-chelated amides from imine and carbon monoxide building blocks. The reaction of (CO)5MnR (R = CH3, Ph) with (p-tolyl)(R1)NR2 (R1 = H, tBu; R2 = alkyl, H) results in the generation of the cyclom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e1f2d2f5164815c71ca3d6a1b33858e
https://doi.org/10.1021/om000745d

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ChemInform Abstract: Mild Decarboxylative Activation of Malonic Acid Derivatives by 1,1′-Carbonyldiimidazole

Autor: Paul Bowles, Danny Lafrance, Robert J. Rafka, Kyle R. Leeman

Publikováno v: ChemInform. 42

The decarboxylation step generates a carbonyl imidazole product which can be trapped with various nucleophiles in an efficient one-pot process.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::347543a29fe3150a49a96256fe30750e
https://doi.org/10.1002/chin.201137050

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