Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals.

Autor: Robert F Hillary, Daniel L McCartney, Hannah M Smith, Elena Bernabeu, Danni A Gadd, Aleksandra D Chybowska, Yipeng Cheng, Lee Murphy, Nicola Wrobel, Archie Campbell, Rosie M Walker, Caroline Hayward, Kathryn L Evans, Andrew M McIntosh, Riccardo E Marioni

Publikováno v: PLoS Medicine, Vol 20, Iss 7, p e1004247 (2023)

BackgroundDNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) investigate the strength of association between methylation at individual CpG si

Externí odkaz: https://doaj.org/article/f0b1e6cceb97419e8873e65cb9b0489b

Epigenetic scores for the circulating proteome as tools for disease prediction

Autor: Danni A Gadd, Robert F Hillary, Daniel L McCartney, Shaza B Zaghlool, Anna J Stevenson, Yipeng Cheng, Chloe Fawns-Ritchie, Cliff Nangle, Archie Campbell, Robin Flaig, Sarah E Harris, Rosie M Walker, Liu Shi, Elliot M Tucker-Drob, Christian Gieger, Annette Peters, Melanie Waldenberger, Johannes Graumann, Allan F McRae, Ian J Deary, David J Porteous, Caroline Hayward, Peter M Visscher, Simon R Cox, Kathryn L Evans, Andrew M McIntosh, Karsten Suhre, Riccardo E Marioni

Publikováno v: eLife, Vol 11 (2022)

Protein biomarkers have been identified across many age-related morbidities. However, characterising epigenetic influences could further inform disease predictions. Here, we leverage epigenome-wide data to study links between the DNA methylation (DNA

Externí odkaz: https://doaj.org/article/97b5228535ef4e2596046a3a97ea7f67

Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health

Autor: Danni A. Gadd, Robert F. Hillary, Daniel L. McCartney, Liu Shi, Aleks Stolicyn, Neil A. Robertson, Rosie M. Walker, Robert I. McGeachan, Archie Campbell, Shen Xueyi, Miruna C. Barbu, Claire Green, Stewart W. Morris, Mathew A. Harris, Ellen V. Backhouse, Joanna M. Wardlaw, J. Douglas Steele, Diego A. Oyarzún, Graciela Muniz-Terrera, Craig Ritchie, Alejo Nevado-Holgado, Tamir Chandra, Caroline Hayward, Kathryn L. Evans, David J. Porteous, Simon R. Cox, Heather C. Whalley, Andrew M. McIntosh, Riccardo E. Marioni

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Characterising associations between the methylome, proteome and phenome may provide insight into biological pathways governing brain health. Here, blood protein markers of brain health are integrated with omics data to reveal DNA methylation differen

Externí odkaz: https://doaj.org/article/1eaa7fc6efbf4260a056871f0b0cae03

Refining epigenetic prediction of chronological and biological age

Autor: Elena Bernabeu, Daniel L McCartney, Danni A Gadd, Robert F Hillary, Ake T Lu, Lee Murphy, Nicola Wrobel, Archie Campbell, Sarah E Harris, David Liewald, Caroline Hayward, Cathie Sudlow, Simon R Cox, Kathryn L Evans, Steve Horvath, Andrew M McIntosh, Matthew R Robinson, Catalina A Vallejos, Riccardo E Marioni

Publikováno v: Bernabeu, E, McCartney, D L, Gadd, D, Hillary, R, Lu, A T, Murphy, L, Wrobel, N, Campbell, A, Harris, S E, Liewald, D C, Hayward, C, Sudlow, C L M, Cox, S R, Evans, K L, Horvath, S, McIntosh, A M, Robinson, M R, Vallejos, C A & Marioni, R E 2023, ' Refining epigenetic prediction of chronological and biological age ', Genome Medicine, vol. 15, no. 1, 12 . https://doi.org/10.1186/s13073-023-01161-y

Background Epigenetic clocks can track both chronological age (cAge) and biological age (bAge). The latter is typically defined by physiological biomarkers and risk of adverse health outcomes, including all-cause mortality. As cohort sample sizes inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d5814cca16d7ebc88338f68a25d155
https://www.pure.ed.ac.uk/ws/files/330163640/s13073_023_01161_y.pdf

Metabolomic investigation of major depressive disorder identifies a potentially causal association with polyunsaturated fatty acids

Autor: Eleanor Davyson, Xueyi Shen, Danni A. Gadd, Elena Bernabeu, Robert F. Hillary, Daniel L. McCartney, Mark Adams, Riccardo Marioni, Andrew M. McIntosh

Publikováno v: Davyson, E, Shen, X, Gadd, D A, Bernabeu, E, Hillary, R F, McCartney, D L, Adams, M, Marioni, R & McIntosh, A M 2023, ' Metabolomic investigation of major depressive disorder identifies a potentially causal association with polyunsaturated fatty acids ', Biological Psychiatry . https://doi.org/10.1016/j.biopsych.2023.01.027

BACKGROUND: Metabolic differences have been reported between individuals with and without major depressive disorder (MDD), but their consistency and causal relevance have been unclear.METHODS: We conducted a metabolome-wide association study of MDD w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665db2ff89d6a49277fb6fc29c58b9ea
https://www.pure.ed.ac.uk/ws/files/337450288/PIIS0006322323000550.pdf