Replication protein A dynamically re-organizes on primer/template junctions to permit DNA polymerase δ holoenzyme assembly and initiation of DNA synthesis.

Autor: Norris JL; Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA., Rogers LO; Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA., Pytko KG; Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA., Dannenberg RL; Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA., Perreault S; Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA., Kaushik V; The Saint Louis University School of Medicine, Department of Biochemistry and Molecular Biology, St. Louis, MO 63104, USA., Kuppa S; The Saint Louis University School of Medicine, Department of Biochemistry and Molecular Biology, St. Louis, MO 63104, USA., Antony E; The Saint Louis University School of Medicine, Department of Biochemistry and Molecular Biology, St. Louis, MO 63104, USA., Hedglin M; Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2024 Jul 22; Vol. 52 (13), pp. 7650-7664.

PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress.

Autor: Muoio D; UPMC Hillman Cancer Center, University of Pittsburgh Cancer Institute, Department of Pharmacology and Chemical Biology, Pittsburgh, PA, 15213, USA., Laspata N; UPMC Hillman Cancer Center, University of Pittsburgh Cancer Institute, Department of Pharmacology and Chemical Biology, Pittsburgh, PA, 15213, USA.; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, 233S. 10th street, Philadelphia, PA, 19107, USA., Dannenberg RL; Department of Chemistry, The Pennsylvania State University, University park, State College, PA, 16802, USA., Curry C; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, 233S. 10th street, Philadelphia, PA, 19107, USA., Darkoa-Larbi S; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, 233S. 10th street, Philadelphia, PA, 19107, USA., Hedglin M; Department of Chemistry, The Pennsylvania State University, University park, State College, PA, 16802, USA., Uttam S; Department of Computational and Systems Biology, UPMC Hillman Cancer Center, University of Pittsburgh, 5117 Centre Avenue, Pittsburgh, PA, 15213, USA., Fouquerel E; UPMC Hillman Cancer Center, University of Pittsburgh Cancer Institute, Department of Pharmacology and Chemical Biology, Pittsburgh, PA, 15213, USA. Elf115@pitt.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Apr 02; Vol. 15 (1), pp. 2857. Date of Electronic Publication: 2024 Apr 02.

Stepwise requirements for polymerases δ and θ in theta-mediated end joining.

Autor: Stroik S; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Carvajal-Garcia J; Department of Biochemistry, Vanderbilt University, Nashville, TN, USA., Gupta D; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA., Edwards A; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Luthman A; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wyatt DW; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Dannenberg RL; Department of Chemistry, The Pennsylvania State University, University Park, PA, USA., Feng W; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kunkel TA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Gupta GP; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hedglin M; Department of Chemistry, The Pennsylvania State University, University Park, PA, USA., Wood R; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center and The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, USA., Doublié S; Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT, USA., Rothenberg E; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA., Ramsden DA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Dale_ramsden@med.unc.edu.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Dale_ramsden@med.unc.edu.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Dale_ramsden@med.unc.edu.

Publikováno v: Nature [Nature] 2023 Nov; Vol. 623 (7988), pp. 836-841. Date of Electronic Publication: 2023 Nov 15.

Tracking of progressing human DNA polymerase δ holoenzymes reveals distributions of DNA lesion bypass activities.

Autor: Dannenberg RL; Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA., Cardina JA; Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA., Pytko KG; Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA., Hedglin M; Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2022 Sep 23; Vol. 50 (17), pp. 9893-9908.