Výsledky vyhledávání

Thiamme2-G, a Novel O-GlcNAcase Inhibitor, Reduces Tau Hyperphosphorylation and Rescues Cognitive Impairment in Mice

Autor: Fei Liu, Chun-ling Dai, Cheng-Xin Gong, Nevena Cekic, David J. Vocadlo, Khalid Iqbal, Jin-hua Gu, Danmin Pan, Yae Hu, Jin Zhang

Publikováno v: Journal of Alzheimer's Disease. 81:273-286

Background: Abnormal hyperphosphorylation of microtubule-associated protein tau plays a pivotal role in Alzheimer’s disease (AD). We previously found that O-GlcNAcylation inversely correlates to hyperphosphorylation of tau in AD brain, and downregu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c6436a03c16aa74a489cbc665e9312
https://doi.org/10.3233/jad-201450

Zobrazit plný text záznamu

Emetine regulates the alternative splicing of caspase 9 in tumor cells

Autor: Piyarat Govitrapong, Kritsanapol Boon-Unge, Danmin Pan, Jianhua Zhou

Publikováno v: Oncology Letters. 2:1309-1312

Exons 3 to 6 in the caspase 9 gene undergo alternative splicing in which the larger caspase 9 splice variant promotes apoptosis, in contrast to the dominant negative anti-apoptotic splice variant, the smaller caspase 9b. In this study, the regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745a672e7fecd641898fb0a5e9b40c1d
https://doi.org/10.3892/ol.2011.395

Zobrazit plný text záznamu

Overexpression of Nrdp1/FLRF sensitizes cells to oxidative stress

Autor: An Zhou, Danmin Pan, Xiaoming Yang, Jianhua Zhou

Publikováno v: Biochemical and biophysical research communications. 410(4)

Nrdp1 is a RING finger containing ubiquitin E3 ligase that interacts with and modulates activity of multiple proteins, including ErbB3 and Parkin, a causative protein for early onset recessive juvenile parkinsonism (AR-JP). To investigate the functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90f316e31d904199d62ecc8a1f66356
https://pubmed.ncbi.nlm.nih.gov/21693106

Zobrazit plný text záznamu

SMN deficiency reduces cellular ability to form stress granules, sensitizing cells to stress

Autor: Jianhua Zhou, Danmin Pan, Tie Zou, Xianming Yang, Jia Huang, Mustafa Sahin

Publikováno v: Cellular and molecular neurobiology. 31(4)

Spinal Muscular Atrophy (SMA) is a neurodegenerative disease that is caused by deletion of the SMN (Survival of Motor Neuron) gene. The SMN protein is essential for cell survival and co-localized with TIA-1/R and G3BP, two characteristic markers of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65cc9f72864af541ff052a13fa962d6
https://pubmed.ncbi.nlm.nih.gov/21234798

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání