Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Danlin Gu"'
Autor:
Haitao Chen, Lili Ren, Hanlu Chen, Qinghua Yao, Zewei Zhang, Yuqi Wang, Danlin Gu, Lu Song, Chao Xu, Lulu Huang, Yuebiao Lai
Publikováno v:
Oncology Reports
Tumor invasion and metastasis are closely associated with epithelial‑mesenchymal transition (EMT). EMT refers to epithelial cells under physiological and pathological conditions that are specific to mesenchymal transition. Curcumin inhibits EMT pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3552c5bbd4809cce78f1a1288683c30
http://europepmc.org/articles/PMC4811403
http://europepmc.org/articles/PMC4811403
Publikováno v:
Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 23(4)
Liver cancer is one of the major causes of cancer related deaths throughout the world and the fifth most common type of malignancy in men and eighth in women. Beta-amyrin has been reported to exhibit significant pharmacological properties and in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c886a170b2733f81d7e0c3295c1fa6e5
https://pubmed.ncbi.nlm.nih.gov/30358200
https://pubmed.ncbi.nlm.nih.gov/30358200
Publikováno v:
Pathology, research and practice. 215(4)
Liver cancer is the third most common cause of cancer related death worldwide. Apatinib showed satisfactory efficacy in various types of cancers, including breast cancer, malignant fibrous histiocytoma and liver cancer. However, how did Apatinib func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9eaec26e57c18a74610f3115c50d065
https://pubmed.ncbi.nlm.nih.gov/30686547
https://pubmed.ncbi.nlm.nih.gov/30686547
Autor:
Richard W. Chapman, Kung-I Feng, Aileen House, James Lamca, Robert G. Aslanian, Chander S. Celly, Rongze Kuang, Danlin Gu, Ping Wu, Zhidan Liu, Jianhua Cao, Daniel Prelusky, Ying Huang, Jonathan E. Phillips, Pauline C. Ting, Peng Wang, Daniel Lundell, Joe F. Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5528-5532
The optimization of oxazole-based PDE4 inhibitor 1 has led to the identification of both oral (compound 16) and inhaled (compound 34) PDE4 inhibitors. Selectivity against PDE10/PDE11, off target screening, and in vivo activity in the rat are discusse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddbd43258d2126bb9cc464f96ed173f1
https://doi.org/10.1016/j.bmcl.2013.08.056
https://doi.org/10.1016/j.bmcl.2013.08.056
Autor:
Kephart Susan Elizabeth, Annette John-Baptiste, Deal Judith G, Danlin Gu, Shubha Bagrodia, Cui Jingrong Jean, Shinji Yamazaki, Djamal Bouzida, Pairish Mason Alan, Evan Smith, Chuangxing Guo, Robert Steven Kania, Dong Liming, Angelica Linton, Indrawan James Mcalpine, Cynthia Louise Palmer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7605-7609
( S )-1-((4-(3-(6-Amino-5-methoxypyridin-3-yl)-1-isopropyl-1 H -pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-ol, 1 , was recently identified as a potent inhibitor of the oncogenic kinase bRAF. Compounds containing 3-methoxy-2-aminopyridine, as in 1 , c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6f7691c31b4bb441f40edfbab8cb91
https://doi.org/10.1016/j.bmcl.2012.10.011
https://doi.org/10.1016/j.bmcl.2012.10.011
Autor:
Piwinski John J, Chander S. Celly, Rongze Kuang, Ping Wu, Pauline C. Ting, Ling Lin, Li Xiao, David J. Blythin, John H. Schwerdt, Xiang Zhang, Ho-Jane Shue, M. Motasim Billah, Xiaohong Zhu, Michael Minnicozzi, Ji Zhang, Neng-Yang Shih, Daniel Prelusky, Peng Wang, Robert G. Aslanian, Danlin Gu, Xiao Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5150-5154
Substituted quinolyl oxazoles were discovered as a novel and highly potent series of phosphodiesterase 4 (PDE4) inhibitors. Structure-activity relationship studies revealed that the oxazole core, with 4-carboxamide and 5-aminomethyl groups, is a nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c528c75f2ffee510f5123556e65ce217
https://doi.org/10.1016/j.bmcl.2007.06.092
https://doi.org/10.1016/j.bmcl.2007.06.092
Autor:
Jean E. Lachowicz, Ruth A. Duffy, Ling Lin, Vicki L. Coffin, Neng-Yang Shih, Danlin Gu, Geoffrey B. Varty, Piwinski John J, Ho-Jane Shue, Cynthia A. Morgan, Gregory A. Reichard, David J. Blythin, John H. Schwerdt, Xiao Chen, Sapna S. Shah, Amin A. Nomeir, Sunil Paliwal, Fei Liu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3896-3899
A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compounds are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04279394fe818201c58f792dfcd83df
https://doi.org/10.1016/j.bmcl.2005.05.111
https://doi.org/10.1016/j.bmcl.2005.05.111
Publikováno v:
Tetrahedron Letters. 35:681-684
Circular Dichroism Spectropolarimetry has proven to be a useful alternative for determining cation binding constants for Na + , K + , and Ca 2+ of the dipeptide derived lariat ethers in anhydrous methanol. The determination of log K S for Ca 2+ for d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfce45df62f02dc74019d6607fbcd706
https://doi.org/10.1016/s0040-4039(00)75789-3
https://doi.org/10.1016/s0040-4039(00)75789-3
Autor:
Pauline C. Ting, Motasim Billah, Ji Zhang, Peng Wang, Daniel Prelusky, David J. Blythin, John H. Schwerdt, John J. Piwinski, Ling Lin, Li Xiao, Xiao Chen, Xiang Zhang, Ho-Jane Shue, Neng-Yang Shih, Jianhua Cao, Ping Wu, Chander S. Celly, Rongze Kuang, Robert G. Aslanian, Danlin Gu
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(7)
Optimization of oxazole-based PDE4 inhibitors has led to the discovery of a series of quinolyl oxazoles, with 4-benzylcarboxamide and 5-α-aminoethyl groups which exhibit picomolar potency against PDE4. Selectivity profiles and in vivo biological act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ef660ee57e97c99ba25220cea0146f
https://pubmed.ncbi.nlm.nih.gov/22401864
https://pubmed.ncbi.nlm.nih.gov/22401864
Autor:
Xiangming Kong, Danlin Gu, Hua Shi, Cuiping Gu, Lili Ren, Yongjun Zhang, Dehou Deng, Wenlong Bao, Aiqin Zhang
Publikováno v:
Gene. 497(1)
Recently, two genome-wide association studies in Asia identified gene polymorphisms known as rs4488809, rs9816619 in TP63 and rs2131877, rs952481 in C3orf21. It has been proposed that these polymorphisms are susceptibility loci for non-small cell lun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12433c2fb08c7cabf8ea1b12549f67d6
https://pubmed.ncbi.nlm.nih.gov/22310392
https://pubmed.ncbi.nlm.nih.gov/22310392