Symmetrical Bispyridinium Compounds Act as Open Channel Blockers of Cation-Selective Ion Channels.

Autor: Haufe Y; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, 80336 Munich, Germany., Loser D; NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770 Reutlingen, Germany., Danker T; NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770 Reutlingen, Germany., Nicke A; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, 80336 Munich, Germany.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2024 Feb 15; Vol. 7 (3), pp. 771-786. Date of Electronic Publication: 2024 Feb 15 (Print Publication: 2024).

Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons.

Autor: Loser D; NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770, Reutlingen, Germany.; NMI TT GmbH, 72770, Reutlingen, Germany.; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany., Hinojosa MG; Department of Biochemistry and Biophysics, Stockholm University, 106 91, Stockholm, Sweden., Blum J; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany., Schaefer J; NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770, Reutlingen, Germany.; NMI TT GmbH, 72770, Reutlingen, Germany., Brüll M; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany., Johansson Y; Department of Biochemistry and Biophysics, Stockholm University, 106 91, Stockholm, Sweden., Suciu I; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany., Grillberger K; Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria., Danker T; NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770, Reutlingen, Germany.; NMI TT GmbH, 72770, Reutlingen, Germany., Möller C; Life Sciences Faculty, Albstadt-Sigmaringen University, 72488, Sigmaringen, Germany., Gardner I; CERTARA UK Limited, Simcyp Division, Level 2-Acero, 1 Concourse Way, Sheffield, S1 2BJ, UK., Ecker GF; Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria., Bennekou SH; Technical University of Denmark, Kongens Lyngby, Denmark., Forsby A; Department of Biochemistry and Biophysics, Stockholm University, 106 91, Stockholm, Sweden., Kraushaar U; NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770, Reutlingen, Germany., Leist M; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany. marcel.leist@uni-konstanz.de.

Publikováno v: Archives of toxicology [Arch Toxicol] 2021 Jun; Vol. 95 (6), pp. 2081-2107. Date of Electronic Publication: 2021 Mar 29.

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology.

Autor: Schaefer J; NMI Natural and Medical Sciences Institute at the University of Tübingen, Germany., Danker T; NMI Natural and Medical Sciences Institute at the University of Tübingen, Germany., Gebhardt K; NMI Natural and Medical Sciences Institute at the University of Tübingen, Germany., Kraushaar U; NMI Natural and Medical Sciences Institute at the University of Tübingen, Germany, ; udo.kraushaar@nmi.de.

Publikováno v: Journal of visualized experiments : JoVE [J Vis Exp] 2022 Sep 13 (187). Date of Electronic Publication: 2022 Sep 13.

Human neuronal signaling and communication assays to assess functional neurotoxicity.

Autor: Loser D; NMI Natural and Medical Sciences Institute at the University of Tuebingen, 72770, Reutlingen, Germany.; NMI TT GmbH, 72770, Reutlingen, Germany.; Life Sciences Faculty, Albstadt-Sigmaringen University, 72488, Sigmaringen, Germany., Schaefer J; NMI Natural and Medical Sciences Institute at the University of Tuebingen, 72770, Reutlingen, Germany.; NMI TT GmbH, 72770, Reutlingen, Germany., Danker T; NMI TT GmbH, 72770, Reutlingen, Germany., Möller C; Life Sciences Faculty, Albstadt-Sigmaringen University, 72488, Sigmaringen, Germany., Brüll M; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Constance, Germany., Suciu I; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Constance, Germany., Ückert AK; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Constance, Germany., Klima S; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Constance, Germany., Leist M; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Constance, Germany. marcel.leist@uni-konstanz.de., Kraushaar U; NMI Natural and Medical Sciences Institute at the University of Tuebingen, 72770, Reutlingen, Germany.

Publikováno v: Archives of toxicology [Arch Toxicol] 2021 Jan; Vol. 95 (1), pp. 229-252. Date of Electronic Publication: 2020 Dec 02.

Corrigendum to "A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm" [Toxicology and Applied Pharmacology volume 394C (2020) 114961].

Autor: Ridder BJ; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA., Leishman DJ; Department of Toxicology and Pathology, Eli Lilly and Company, Indianapolis, IN, USA., Bridgland-Taylor M; Clinical Pharmacology & Safety Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Samieegohar M; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA., Han X; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA., Wu WW; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA., Randolph A; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA., Tran P; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA., Sheng J; CiPA LAB, 900 Clopper Rd, Suite 130, Gaithersburg, MD 20878, USA., Danker T; NMI-TT GmbH, Markwiesenstr. 55, 72770 Reutlingen, Germany., Lindqvist A; Sophion Bioscience A/S, Baltorpvej 154, 2750 Ballerup, Denmark., Konrad D; B'SYS GmbH, The Ion Channel Company, Benkenstrasse 254, CH-4108 Witterswil, Switzerland., Hebeisen S; B'SYS GmbH, The Ion Channel Company, Benkenstrasse 254, CH-4108 Witterswil, Switzerland., Polonchuk L; F. Hoffmann-La Roche AG, F. Hoffmann-La Roche Ltd., Bldg. 73 / R. 103b Grenzacherstrasse, 124, CH-4070, Basel, Switzerland., Gissinger E; F. Hoffmann-La Roche AG, F. Hoffmann-La Roche Ltd., Bldg. 73 / R. 103b Grenzacherstrasse, 124, CH-4070, Basel, Switzerland., Renganathan M; Eurofins Scientific, Eurofins Discovery, 6 Research Park Drive, St. Charles, MO 63304, USA., Koci B; Eurofins Scientific, Eurofins Discovery, 6 Research Park Drive, St. Charles, MO 63304, USA., Wei H; Eurofins Scientific, Eurofins Discovery, 6 Research Park Drive, St. Charles, MO 63304, USA., Fan J; Bristol-Myers Squibb Company, Discovery Toxicology, Bristol-Myers Squibb, 3551 Lawrenceville, Princeton Rd, Lawrence Township, NJ 08648, USA., Levesque P; Bristol-Myers Squibb Company, Discovery Toxicology, Bristol-Myers Squibb, 3551 Lawrenceville, Princeton Rd, Lawrence Township, NJ 08648, USA., Kwagh J; Bristol-Myers Squibb Company, Discovery Toxicology, Bristol-Myers Squibb, 3551 Lawrenceville, Princeton Rd, Lawrence Township, NJ 08648, USA., Imredy J; Merck & Co., Inc., Kenilworth, NJ, USA., Zhai J; Merck & Co., Inc., Kenilworth, NJ, USA., Rogers M; Metrion Biosciences Limited, Riverside 3, Suite 1, Granta Park, Great Abington, Cambridge CB21 6AD, United Kingdom., Humphries E; Metrion Biosciences Limited, Riverside 3, Suite 1, Granta Park, Great Abington, Cambridge CB21 6AD, United Kingdom., Kirby R; Metrion Biosciences Limited, Riverside 3, Suite 1, Granta Park, Great Abington, Cambridge CB21 6AD, United Kingdom., Stoelzle-Feix S; Nanion Technologies Munich, Ganghoferstrasse 70A, 80339 Munich, Germany., Brinkwirth N; Nanion Technologies Munich, Ganghoferstrasse 70A, 80339 Munich, Germany., Rotordam MG; Nanion Technologies Munich, Ganghoferstrasse 70A, 80339 Munich, Germany., Becker N; Nanion Technologies Munich, Ganghoferstrasse 70A, 80339 Munich, Germany., Friis S; Nanion Technologies Munich, Ganghoferstrasse 70A, 80339 Munich, Germany., Rapedius M; Nanion Technologies Munich, Ganghoferstrasse 70A, 80339 Munich, Germany., Goetze TA; Nanion Technologies Munich, Ganghoferstrasse 70A, 80339 Munich, Germany., Strassmaier T; Nanion Technologies USA, 1 Naylon Place, Suite C, Livingston, NJ 07039, USA., Okeyo G; Nanion Technologies USA, 1 Naylon Place, Suite C, Livingston, NJ 07039, USA., Kramer J; Charles River Laboratories, 14656 Neo Parkway, Cleveland, OH 44128, USA., Kuryshev Y; Charles River Laboratories, 14656 Neo Parkway, Cleveland, OH 44128, USA., Wu C; Charles River Laboratories, 14656 Neo Parkway, Cleveland, OH 44128, USA., Himmel H; Bayer AG, RD-TS-TOX-SP-SPL1, Aprather Weg 18a, 42096 Wuppertal, Germany., Mirams GR; Centre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom., Strauss DG; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA., Bardenet R; Université de Lille, CNRS, Centrale Lille, UMR 9189 - CRIStAL, Villeneuve d'Ascq, France., Li Z; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. Electronic address: Zhihua.li@fda.hhs.gov.

Publikováno v: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 May 15; Vol. 395, pp. 114983. Date of Electronic Publication: 2020 Apr 02.