Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Danja J. Den Hartogh"'
Muscle Cell Insulin Resistance Is Attenuated by Rosmarinic Acid: Elucidating the Mechanisms Involved
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5094 (2023)
Obesity and elevated blood free fatty acid (FFA) levels lead to impaired insulin action causing insulin resistance in skeletal muscle, and contributing to the development of type 2 diabetes mellitus (T2DM). Mechanistically, insulin resistance is asso
Externí odkaz:
https://doaj.org/article/bf7cd439dfe54ae0824ce0bade3d6290
Autor:
Danja J. Den Hartogh, Filip Vlavcheski, Adria Giacca, Rebecca E. K. MacPherson, Evangelia Tsiani
Publikováno v:
Cells, Vol 11, Iss 1, p 167 (2022)
Elevated blood free fatty acids (FFAs), as seen in obesity, impair insulin action leading to insulin resistance and Type 2 diabetes mellitus. Several serine/threonine kinases including JNK, mTOR, and p70 S6K cause serine phosphorylation of the insuli
Externí odkaz:
https://doaj.org/article/4ac0ea7041e54973b4a0b5c900b92a78
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9136 (2021)
Bone is a highly dynamic tissue that is constantly adapting to micro-changes to facilitate movement. When the balance between bone building and resorption shifts more towards bone resorption, the result is reduced bone density and mineralization, as
Externí odkaz:
https://doaj.org/article/9b5c03b15a554a26855233e4a87ac7bb
Publikováno v:
Biomolecules, Vol 10, Iss 11, p 1536 (2020)
Cancer is a condition characterized by remarkably enhanced rates of cell proliferation paired with evasion of cell death. These deregulated cellular processes take place following genetic mutations leading to the activation of oncogenes, the loss of
Externí odkaz:
https://doaj.org/article/097b34ae465345c68e9f11b4a68fff72
Publikováno v:
Antioxidants, Vol 9, Iss 10, p 961 (2020)
Cancer is characterized by unrestricted cell proliferation, inhibition of apoptosis, enhanced invasion and migration, and deregulation of signalling cascades. These properties lead to uncontrolled growth, enhanced survival, and the formation of tumou
Externí odkaz:
https://doaj.org/article/e775c18a46294ad98b541feade6fae48
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 14, p 4900 (2020)
Insulin resistance, a main characteristic of type 2 diabetes mellitus (T2DM), is linked to obesity and excessive levels of plasma free fatty acids (FFA). Studies indicated that significantly elevated levels of FFAs lead to skeletal muscle insulin res
Externí odkaz:
https://doaj.org/article/92fea8f7036c4bc2bd1e5fd9ed91f225
Publikováno v:
Nutrients, Vol 12, Iss 4, p 914 (2020)
Insulin resistance, the hallmark of type 2 diabetes mellitus (T2DM), is linked to hyperinsulinemia, which develops to counterbalance initial peripheral hormone resistance. Studies indicate that chronically elevated levels of insulin lead to skeletal
Externí odkaz:
https://doaj.org/article/bff7a47b398a4ec79b20af3a59f98a52
Publikováno v:
Nutrients, Vol 12, Iss 1, p 118 (2020)
Type 2 diabetes mellitus (T2DM) is a growing metabolic disease characterized by insulin resistance and hyperglycemia. Current preventative and treatment strategies for T2DM and insulin resistance lack in efficacy resulting in the need for new approac
Externí odkaz:
https://doaj.org/article/c0bc0c5808c04dda82b4ac6ec66f4665
Publikováno v:
Nutrients, Vol 12, Iss 1, p 58 (2019)
Type 2 diabetes mellitus (T2DM) is a growing metabolic disease characterized by insulin resistance and hyperglycemia. Current preventative and treatment approaches to insulin resistance and T2DM lack in efficacy, resulting in the need for new approac
Externí odkaz:
https://doaj.org/article/c7984b89f08744b19627448738aeb681
Autor:
Danja J. Den Hartogh, Evangelia Tsiani
Publikováno v:
Nutrients, Vol 11, Iss 7, p 1624 (2019)
Different diseases and disorders that affect the kidneys include, but are not limited to, glomerulonephritis, diabetic nephropathy, polycystic kidney disease, kidney stones, renal fibrosis, sepsis, and renal cell carcinoma. Kidney disease tends to de
Externí odkaz:
https://doaj.org/article/b4594dca9ce644e9bbdf2af65a64245c