Rheological Impact of GBT1118 Cessation in a Sickle Mouse Model

Autor: Celeste K. Kanne, Danitza Nebor, Mira Pochron, Donna Oksenberg, Vivien A. Sheehan

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

In sickle cell disease (SCD), higher whole blood viscosity is a risk factor for vaso-occlusive crisis, avascular necrosis, and proliferative retinopathy. Blood viscosity is strongly impacted by hemoglobin (Hb) levels and red blood cell (RBC) deformab

Externí odkaz: https://doaj.org/article/ddc0d935231c431eab449bccda6c81f2

Frequency of pain crises in sickle cell anemia and its relationship with the sympatho-vagal balance, blood viscosity and inflammation

Autor: Danitza Nebor, Andre Bowers, Marie-Dominique Hardy-Dessources, Jennifer Knight-Madden, Marc Romana, Harvey Reid, Jean-Claude Barthélémy, Vanessa Cumming, Olivier Hue, Jacques Elion, Marvin Reid, Philippe Connes, CAREST study group

Publikováno v: Haematologica, Vol 96, Iss 11 (2011)

Background Recent evidence suggests that autonomic nervous system activity could be involved in the pathophysiology of sickle cell disease, but it is unclear whether differences in autonomic nervous system activity are detectable during steady state

Externí odkaz: https://doaj.org/article/e2d95c3645f44b90826f2d9e8dddb6e2

Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered Erythropoiesis

Autor: James J. Bieker, Danitza Nebor, Emily Hartman, Julien Papoin, Raymond F. Robledo, Joel H. Graber, Steven L. Ciciotte, Kevin R. Gillinder, Andrew C. Perkins, Luanne L. Peters, Lionel Blanc

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)

Anemic Nan mice carry a mutation (E339D) in the second zinc finger of erythroid transcription factor KLF1. Nan-KLF1 fails to bind a subset of normal KLF1 targets and ectopically binds a large set of genes not normally engaged by KLF1, resulting in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6efb9819f8defbde82c847f45bb94d7
https://pubmed.ncbi.nlm.nih.gov/30143664

Fetal hemoglobin and hydroxycarbamide moduate both plasma concentration and cellular origin of circulating microparticles in sickle cell anemia children

Autor: Nathalie Vachiery, Marie-Hélène Odièvre, Cédric Broquere, Malika Benkerrou, Danitza Nebor, Vicky Chaar, Julien Picot, Raoul Santiago, Jacques Elion, Lydia Doumdo, Marc Romana

Publikováno v: Haematologica
Haematologica, Ferrata Storti Foundation, 2013, 98 (6), pp.862-867. ⟨10.3324/haematol.2012.073619⟩
Haematologica 6 (98), 862-867. (2013)

International audience; Microparticles are cell membrane-derived microvesicles released during cell apoptosis and activation processes. They have been described as bio-markers in various vascular diseases, including sickle cell anemia, and associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa65540efc4ccff73cd006c1c4ccd49
https://pubmed.ncbi.nlm.nih.gov/23403312

Frequency of pain crises in sickle cell anemia and its relationship with the sympatho-vagal balance, blood viscosity and inflammation

Autor: Andre S. Bowers, Philippe Connes, Vanessa Cumming, Marie-Dominique Hardy-Dessources, Marc Romana, Jean-Claude Barthélémy, Jennifer Knight-Madden, Danitza Nebor, H. L. Reid, Jacques Elion, Marvin Reid, Olivier Hue

Publikováno v: Haematologica. 96(11)

Recent evidence suggests that autonomic nervous system activity could be involved in the pathophysiology of sickle cell disease, but it is unclear whether differences in autonomic nervous system activity are detectable during steady state in patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b43052ab432f78579596884772e754
https://pubmed.ncbi.nlm.nih.gov/21750084