NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

Autor: Tingting Niu, Charlotte De Rosny, Séverine Chautard, Amaury Rey, Danish Patoli, Marine Groslambert, Camille Cosson, Brice Lagrange, Zhirong Zhang, Orane Visvikis, Sabine Hacot, Maggy Hologne, Olivier Walker, Jeimin Wong, Ping Wang, Roméo Ricci, Thomas Henry, Laurent Boyer, Virginie Petrilli, Bénédicte F. Py

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Nlrp3 inflammasome activation requires Nek7 recruitment to drive ASC speck formation. Here the authors show how Nlrp3 phosphorylation events control this Nek7 recruitment.

Externí odkaz: https://doaj.org/article/fbcf468393234f91b37ce912376f58ab

Polysaccharide Chain Length of Lipopolysaccharides From Salmonella Minnesota Is a Determinant of Aggregate Stability, Plasma Residence Time and Proinflammatory Propensity in vivo

Autor: Wahib Sali, Danish Patoli, Jean-Paul Pais de Barros, Jérôme Labbé, Valérie Deckert, Vincent Duhéron, Naig Le Guern, Denis Blache, Denis Chaumont, Eric Lesniewska, Benoit Gasquet, Catherine Paul, Mathieu Moreau, Franck Denat, David Masson, Laurent Lagrost, Thomas Gautier

Publikováno v: Frontiers in Microbiology, Vol 10 (2019)

Lipopolysaccharides (LPS) originate from the outer membrane of Gram-negative bacteria and trigger an inflammatory response via the innate immune system. LPS consist of a lipid A moiety directly responsible for the stimulation of the proinflammatory c

Externí odkaz: https://doaj.org/article/8bced7c847df48ccae8e7cc0b244d0d3

Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway.

Autor: Wafa Zeriouh, Abdelhafid Nani, Meriem Belarbi, Adélie Dumont, Charlotte de Rosny, Ikram Aboura, Fatima Zahra Ghanemi, Babar Murtaza, Danish Patoli, Charles Thomas, Lionel Apetoh, Cédric Rébé, Dominique Delmas, Naim Akhtar Khan, François Ghiringhelli, Mickael Rialland, Aziz Hichami

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0170823 (2017)

Dietary polyphenols, derived from natural products, have received a great interest for their chemopreventive properties against cancer. In this study, we investigated the effects of phenolic extract of the oleaster leaves (PEOL) on tumor growth in mo

Externí odkaz: https://doaj.org/article/5283e02bc57442be910c0abc1c3adc5c

GPR75: An exciting new target in metabolic syndrome and related disorders

Autor: Babar Murtaza, Faiza Asghar, Danish Patoli

Publikováno v: Biochimie. 195

The metabolic syndrome is a plethora of related disorders that are frequently associated with morbidity and mortality in addition to economic burden. While various treatment options are available, the need to understand the pathology and find new tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bc4d0545c376b4813fd794e48e6200
https://pubmed.ncbi.nlm.nih.gov/35045335

Inhibition of mitophagy drives macrophage activation and anti-bacterial defense during sepsis

Autor: Danish, Patoli, Franck, Mignotte, Valérie, Deckert, Alois, Dusuel, Adélie, Dumont, Aurélie, Rieu, Antoine, Jalil, Kevin, Van Dongen, Thibaut, Bourgeois, Thomas, Gautier, Charlène, Magnani, Naig, Le Guern, Stéphane, Mandard, Jean, Bastin, Fatima, Djouadi, Christine, Schaeffer, Nina, Guillaumot, Michel, Narce, Maxime, Nguyen, Julien, Guy, Auguste, Dargent, Jean-Pierre, Quenot, Mickaël, Rialland, David, Masson, Johan, Auwerx, Laurent, Lagrost, Charles, Thomas

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2020, 130996, Online ahead of print. ⟨10.1172/JCI130996⟩
Journal of Clinical Investigation, 2020, 130996, Online ahead of print. ⟨10.1172/JCI130996⟩
J Clin Invest

International audience; Mitochondria have emerged as key actors of innate and adaptive immunity. Mitophagy has a pivotal role in cell homeostasis but its contribution to macrophage functions and host defense remains to be delineated. Here we showed t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6d51b08d85cf60fc9a121f9576d08480
https://www.hal.inserm.fr/inserm-02926629