Synthetic (E)-3-Phenyl-5-(phenylamino)-2-styryl-1,3,4-thiadiazol-3-ium Chloride Derivatives as Promising Chemotherapy Agents on Cell Lines Infected with HTLV-1

Autor: Danilo Sousa-Pereira, Thais Silva de Oliveira, Rojane O. Paiva, Otávio Augusto Chaves, José C. Netto-Ferreira, Juliana Echevarria-Lima, Aurea Echevarria

Publikováno v: Molecules, Vol 25, Iss 11, p 2537 (2020)

Synthesis of four compounds belonging to mesoionic class, (E)-3-phenyl-5-(phenylamino)-2-styryl-1,3,4-thiadiazol-3-ium chloride derivatives (5a–d) and their biological evaluation against MT2 and C92 cell lines infected with human T-cell lymphotropi

Externí odkaz: https://doaj.org/article/8c583559d716454785ffa71953985549

Novel piperonal 1,3,4-thiadiazolium-2-phenylamines mesoionic derivatives: Synthesis, tyrosinase inhibition evaluation and HSA binding study

Autor: José Carlos Netto-Ferreira, Natália D. Lopes, Aurea Echevarria, Carlos Mauricio R. Sant'Anna, Márcia C.C. de Oliveira, Danilo Sousa-Pereira, Otávio Augusto Chaves

Publikováno v: International Journal of Biological Macromolecules. 112:1062-1072

A novel series of piperonal mesoionic derivatives (PMI 1-6) was synthesized. Tyrosinase inhibition in the presence of PMI-1, -2, -3, -4, -5 and -6 as well as human serum albumin (HSA) binding studies with PMI-5 and PMI-6 were done by spectroscopic an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1ce1d18b46169bfed1bd179954028d
https://doi.org/10.1016/j.ijbiomac.2018.02.050

O Ensino de Química 2

Autor: Anna Celia Silva Arruda, Larisse Ferreira Tavares, Nicéa Quintino Amauro, Evelyn Leal De Carvalho, Eliel Benites, Giovana França Carneiro Fernandes, Felipe Cunha Fonseca Nascimento, Fernanda Rechotnek, Marlon Cavalcante Maynart, Bruno Mariani Ribeiro, Maurício Bruno, Maurício Bruno Da Silva Costa, Verônica Santos De Morais, Daniela Kubota, Karla Pereira Rainha, Gabriele Novais Alves, Thiago Santos Duarte, Grazielle De Oliveira Setti, Laís Perpétuo Perovano, Eustáquio Vinicius Ribeiro De Castro, Ailnete Mário Do Nascimento, Thaynara Dannehl Hoppe, Juliana Meuci Bastos Machado, Ana Nery Furlan Mendes, Janessa Aline Zappe, Beatriz Pereira Do Nascimento, Dylan Ávila Alves, Maxwell Severo Da Costa, Elaine Cintra Pavini, Gustavo Bizarria Gibin, Dhessi Rodrigues, Thaina Cristal Santos, Ailnete Mário Donascimento Nete Nascimento, Luciana Aparecida Siqueira Silva, Denise De Castro Bertagnolli, Nêmora Francine Backes, Magda Mantovani Lorandi, Eilane Barreto Da Cunha Dote, Márcia Valéria Gaspar De Araújo, Adriângela Guimarães De Paula, Guimes Rodrigues Filho, Matheus Estevam, Alceu Junior Paz Da Silva, Paulo Vitor Teodoro De Souza, Marina Cardoso Dilelio, Merícia Paula De Oliveira Almeida, Lara De Amaral Sibo, Nara Alinne Nobre Da Silva, Daniele Cristina Da Silva, Patrícia Dos Santos Schneid, Paula Sartori, Tiago Souza De Jesus, Carla Cristina Da Silva, Maria Vitória Dunice Pereira, Carlos Fernando Barboza Da Silva, Joceline Maria Da Costa Soares, Gabriela Rosângela Dos Santos, Adriana Marques De Oliveira, Daniela Brondani, Rafael Cava Mori, Marcos Antonio Da Silva, Eliana Maria Aricó, Marcos Antônio Pinto Ribeiro, Amanda Bobbio Pontara, Maria José Sá Barreto Queiroz, Naira Caroline Vieira De Souza, Ludmila Nogueira Da Silva, Adriano Lopes Romero, Sandra Noemi Finzi, Diane Cristina Araújo Domingos, Gustavo Adolfo Araújo De Simas, Márcia Bay, Eliene Cirqueira Santos, Venina Dos Santos, Lidiane Jorge Michelini, Tatiana Kubota, Tania Renata Prochnow, Elâine Da Silva Ladeia, Renato Campelo Duarte Andreza Lima Pires, João Vitor Souza De Oliveira, Maria Alice Reis Pacheco, Natacha Martins Bomfim Barreto, Mariana Gonçalves Dias, Lenalda Dias Dos Santos, Danilo Sousa Pereira, Christina Vargas Miranda E Carvalho, Filipe Rodrigo De Souza Batista, Rafaelle Bonzanini Romero, Gabriele Smanhotto Malvessi, Luciano Dornelles, Aparecida Cayoco Ikuhara Ponzoni, Joicemara De Queiroz Souza, Gabriel Dos Santos Ramos, Joseli Silva Costa, Inés Prieto Schmidt Sauerwein, Larissa Aigner Da Vitória, Leandro Gouveia Almeida, Saionara Andrade De Santana Santos, Sinara München, Ana Luiza De Quadros, Alzira Yamasaki, Ana Paula Bernardo Dos Santos, Eleandro Adir Philippsen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29aa090b246b7b514f23fe47f7b51ea5
https://doi.org/10.22533/at.ed.906192604

Synthesis and biological evaluation of N-aryl-2-phenyl-hydrazinecarbothioamides: Experimental and theoretical analysis on tyrosinase inhibition and interaction with HSA

Autor: José Carlos Netto-Ferreira, Otávio Augusto Chaves, Aurea Echevarria, Danilo Sousa-Pereira, Márcia C.C. de Oliveira, Carlos Mauricio R. Sant'Anna, Camilla Moretto dos Reis

Publikováno v: Bioorganic chemistry. 81

A series of N-aryl-2-phenyl-hydrazinecarbothioamides have been investigated as possible inhibitors of tyrosinase, an enzyme involved in the development of melanomas. The hydrazinecarbothioamides 1–6 were synthesized from the reaction between phenyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b192b150ece299eff7664e1a2e5722be
https://pubmed.ncbi.nlm.nih.gov/30118988

Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones

Autor: Camilla Moretto dos, Reis, Danilo Sousa, Pereira, Rojane de Oliveira, Paiva, Lucimar Ferreira, Kneipp, Aurea, Echevarria

Publikováno v: Molecules

We present an efficient procedure for the synthesis of thirty-six N1,N4-substituted thiosemicarbazones, including twenty-five ones that are reported for the first time, using a microwave-assisted methodology for the reaction of thiosemicarbazide inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f58723d5feb1da0745c229839d84fbb
https://pubmed.ncbi.nlm.nih.gov/22186954