Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Danilo R. Casimiro"'
Autor:
Aimin Tang, Zhifeng Chen, Kara S. Cox, Hua-Poo Su, Cheryl Callahan, Arthur Fridman, Lan Zhang, Sangita B. Patel, Pedro J. Cejas, Ryan Swoyer, Sinoeun Touch, Michael P. Citron, Dhanasekaran Govindarajan, Bin Luo, Michael Eddins, John C. Reid, Stephen M. Soisson, Jennifer Galli, Dai Wang, Zhiyun Wen, Gwendolyn J. Heidecker, Danilo R. Casimiro, Daniel J. DiStefano, Kalpit A. Vora
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization. Here, the authors isolate a human monoclonal antibody that binds to a highly conserved epitope on the RSV fusion protein, neutralizes RSV A and B subtypes equipotently an
Externí odkaz:
https://doaj.org/article/353ee58e3241465cbd5aae22b7984ad3
Autor:
Slim Fourati, Razvan Cristescu, Andrey Loboda, Aarthi Talla, Ali Filali, Radha Railkar, Andrea K. Schaeffer, David Favre, Dominic Gagnon, Yoav Peretz, I-Ming Wang, Chan R. Beals, Danilo R. Casimiro, Leonidas N. Carayannopoulos, Rafick-Pierre Sékaly
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Ageing is associated with poor responses to vaccines but the underlying mechanism remains unclear. Here the authors use a systems-based approach to define molecular signatures present before vaccination that correlate with non-responsiveness to hepat
Externí odkaz:
https://doaj.org/article/3d312c5aa0404caa898a6b2a5c38fdde
Autor:
Wei Zhang, I-Ming Wang, Changxi Wang, Liya Lin, Xianghua Chai, Jinghua Wu, Andrew J. Bett, Dhanasekaran Govindarajan, Danilo R. Casimiro, Xiao Liu
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Large-scale study of the properties of T-cell receptor (TCR) and B-cell receptor (BCR) repertoires through next-generation sequencing is providing excellent insights into the understanding of adaptive immune responses. Variable(Diversity)Joining V(D)
Externí odkaz:
https://doaj.org/article/cc01d3d261ed4259bf5ccf3da2407da0
Autor:
Elizabeth A. Thoryk, Gokul Swaminathan, Steven Meschino, Kara S. Cox, Marian Gindy, Danilo R. Casimiro, Andrew J. Bett
Publikováno v:
Vaccines, Vol 4, Iss 4, p 47 (2016)
A vast body of evidence suggests that nanoparticles function as potent immune-modulatory agents. We have previously shown that Merck proprietary Lipid NanoParticles (LNPs) markedly boost B-cell and T-cell responses to sub-unit vaccine antigens in mic
Externí odkaz:
https://doaj.org/article/882211fd99744c5e9e757de3944ac9a1
Autor:
JoAnne L. Flynn, Patricia A. Darrah, Phillip A. Swanson, Nicole L. Grant, Pauline Maiello, Chelsea M Causgrove, Travis K. Hughes, Danilo R. Casimiro, Megha Kamath, Joseph J. Zeppa, Edwin Klein, Supriya Pokkali, Alexander G. White, Mario Roederer, Philana Ling Lin, Joshua A Hackney, Aurelio Bonavia, Charles A. Scanga, Marc H. Wadsworth, Alex K. Shalek, Robert A. Seder, Dominick Laddy, Mark Rodgers
Publikováno v:
Nature. 577:95-102
Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide1. The only available vaccine, BCG (Bacillus Calmette–Guerin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause o
Autor:
Danilo R. Casimiro, Tsin W. Yeo, Menaka Priyadharsani Rajapakse, Vanessa W. Lim, Bernett Lee, Laura Rivino, Amit Singhal, Bing Lim, Tun-Linn Thein, Thomas Loy, Melissa Hui Yen Chng, Durgalakshmi Sathiakumar, Kalpit A. Vora, Katja Fink, Lisa Tucker-Kellogg, Ying Xiu Toh, Angeline Rouers, Kaval Kaur, Yee Sin Leo, Evan W. Newell
Publikováno v:
Cell Reports Medicine
Cell Reports Medicine, Vol 2, Iss 5, Pp 100278-(2021)
Cell Reports Medicine, Vol 2, Iss 5, Pp 100278-(2021)
Summary Prior immunological exposure to dengue virus can be both protective and disease-enhancing during subsequent infections with different dengue virus serotypes. We provide here a systematic, longitudinal analysis of B cell, T cell, and antibody
Autor:
Danilo R. Casimiro, Lisa Tucker-Kellogg, Ying Xiu Toh, Kaval Kaur, Yee Sin Leo, Durgalakshmi Sathiakumar, Melissa Hui Yen Chng, Laura Rivino, Menaka Priyadharsani Rajapakse, Bing Lim, Bernett Lee, Kalpit A. Vora, Katja Fink, Angeline Rouers, Evan W. Newell
Publikováno v:
SSRN Electronic Journal.
Prior immunological exposure to dengue virus can be both protective and disease-enhancing during subsequent infections with different dengue virus serotypes. We provide here for the first time a systematic, longitudinal analysis of B cell, T cell, an
Autor:
Krista G. Haanstra, Chantal Hoffmann, Aurelio Bonavia, Patricia A. Darrah, Stéphane Leung-Theung-Long, H. Jacob Borish, Dominick Laddy, Robert A. Seder, Danilo R. Casimiro, Frank A. W. Verreck, Claudia C. Sombroek, Charelle Boot, Nathalie Silvestre, Mary Limbach, Geneviève Inchauspé, Richard A. W. Vervenne, Alexander G. White, Karin Dijkman, Mohamed A Khayum, Michel P.M. Vierboom, Doris Schmitt, Marieke A. Stammes, Maria Lempicki, Nadia Ouaked, Ravi Anantha, Sam O. Hofman, Agnes L Chenine, Thomas G. Evans
Publikováno v:
NPJ Vaccines
npj Vaccines, Vol 5, Iss 1, Pp 1-12 (2020)
npj Vaccines, Vol 5, Iss 1, Pp 1-12 (2020)
Tuberculosis (TB) still is the principal cause of death from infectious disease and improved vaccination strategies are required to reduce the disease burden and break TB transmission. Here, we investigated different routes of administration of vecto
Autor:
Dai Wang, Andrew J. Bett, Michael Prokop, Danilo R. Casimiro, Daniel C. Freed, Tong-Ming Fu, Aimin Tang, Fengsheng Li, Steve Meschino
Publikováno v:
Human Vaccines & Immunotherapeutics
T cell immunity is critical in controlling human cytomegalovirus (HCMV) infection in transplant recipients, and T cells targeting viral immediate early proteins such as IE1, IE2 and pp65 have been speculated to be more effective against reactivation.
Characterization of N -glycosylation profiles from mammalian and insect cell derived chikungunya VLP
Autor:
Richard M. Schwartz, Catherine Lancaster, Richard R. Rustandi, Sha Ha, Danilo R. Casimiro, Van M. Hoang, Pavlo Pristatsky
Publikováno v:
Journal of Chromatography B. 1032:218-223
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes severe arthralgia. The envelope of CHIKV is composed of 240 copies of two glycoproteins: E1 and E2. In this work, we have characterized the N-glycosylation patterns of CHIKV virus-l