Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Danilo R Casimiro"'
Potent neutralizing antibodies elicited by dengue vaccine in rhesus macaque target diverse epitopes.
Autor:
Leike Li, Weixu Meng, Melanie Horton, Daniel R DiStefano, Elizabeth A Thoryk, Jennifer M Pfaff, Qihui Wang, Georgina T Salazar, Trevor Barnes, Benjamin J Doranz, Andrew J Bett, Danilo R Casimiro, Kalpit A Vora, Zhiqiang An, Ningyan Zhang
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007716 (2019)
There is still no safe and effective vaccine against dengue virus infection. Epidemics of dengue virus infection are increasingly a threat to human health around the world. Antibodies generated in response to dengue infection have been shown to impac
Externí odkaz:
https://doaj.org/article/987313e68b584a3482591ce5d30cb479
Autor:
Dhanasekaran Govindarajan, Liming Guan, Steven Meschino, Arthur Fridman, Ansu Bagchi, Irene Pak, Jan ter Meulen, Danilo R Casimiro, Andrew J Bett
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152209 (2016)
Dengue is one of the most important mosquito-borne infections accounting for severe morbidity and mortality worldwide. Recently, the tetravalent chimeric live attenuated Dengue vaccine Dengvaxia® was approved for use in several dengue endemic countr
Externí odkaz:
https://doaj.org/article/d9159dd00b534679b40888da1c3e0a7b
Autor:
James M Wagner, J David Pajerowski, Christopher L Daniels, Patrick M McHugh, Jessica A Flynn, John W Balliet, Danilo R Casimiro, Shyamsundar Subramanian
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94401 (2014)
Chikungunya virus-like particles (VLPs) have potential to be used as a prophylactic vaccine based on testing in multiple animal models and are currently being evaluated for human use in a Phase I clinical trial. The current method for producing these
Externí odkaz:
https://doaj.org/article/de84d5cc23ff4b7a97129b9a9cf8fabb
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e101373 (2014)
We recently constructed a novel non-replicating dominant-negative HSV-2 recombinant viral vaccine (CJ2-gD2) capable of expressing various HSV-2 antigens that are dominant targets of HSV-2-specific CD8 T-cell response. Importantly, CJ2-gD2 expresses g
Externí odkaz:
https://doaj.org/article/d58c00fe094848339728088feb4a8a7a
Autor:
Tomer Hertz, Hasan Ahmed, David P Friedrich, Danilo R Casimiro, Steven G Self, Lawrence Corey, M Juliana McElrath, Susan Buchbinder, Helen Horton, Nicole Frahm, Michael N Robertson, Barney S Graham, Peter Gilbert
Publikováno v:
PLoS Pathogens, Vol 9, Iss 6, p e1003404 (2013)
Several recent large clinical trials evaluated HIV vaccine candidates that were based on recombinant adenovirus serotype 5 (rAd-5) vectors expressing HIV-derived antigens. These vaccines primarily elicited T-cell responses, which are known to be crit
Externí odkaz:
https://doaj.org/article/65453933a1c548b5b4a92a58148c1113
Autor:
Samuel O Pine, James G Kublin, Scott M Hammer, Joleen Borgerding, Yunda Huang, Danilo R Casimiro, M Juliana McElrath
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18526 (2011)
The results of the recent Step Study highlight a need to clarify the effects of pre-existing natural immunity to a vaccine vector on vaccine-induced T-cell responses. To investigate this interaction, we examined the relationship between pre-existing
Externí odkaz:
https://doaj.org/article/01ea84be10164d5fbaab8fb7118ddb29
Autor:
Fusheng Li, Adam C Finnefrock, Sheri A Dubey, Bette T M Korber, James Szinger, Suzanne Cole, M Juliana McElrath, John W Shiver, Danilo R Casimiro, Lawrence Corey, Steven G Self
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20479 (2011)
T cell directed HIV vaccines are based upon the induction of CD8+ T cell memory responses that would be effective in inhibiting infection and subsequent replication of an infecting HIV-1 strain, a process that requires a match or near-match between t
Externí odkaz:
https://doaj.org/article/f5a5c2cd74964d488c8390d72ef137c1
Autor:
Natalie A Hutnick, Diane G Carnathan, Sheri A Dubey, Kara S Cox, Lisa Kierstead, George Makadonas, Sarah J Ratcliffe, Marcio O Lasaro, Michael N Robertson, Danilo R Casimiro, Hildegund C J Ertl, Michael R Betts
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14385 (2010)
Adenoviral (Ad) vaccine vectors represent both a vehicle to present a novel antigen to the immune system as well as restimulation of immune responses against the Ad vector itself. To what degree Ad-specific CD8(+) T cells are restimulated by Ad vecto
Externí odkaz:
https://doaj.org/article/cedc147c5422474d948e752b10f259e7
Autor:
JoAnne L. Flynn, Patricia A. Darrah, Phillip A. Swanson, Nicole L. Grant, Pauline Maiello, Chelsea M Causgrove, Travis K. Hughes, Danilo R. Casimiro, Megha Kamath, Joseph J. Zeppa, Edwin Klein, Supriya Pokkali, Alexander G. White, Mario Roederer, Philana Ling Lin, Joshua A Hackney, Aurelio Bonavia, Charles A. Scanga, Marc H. Wadsworth, Alex K. Shalek, Robert A. Seder, Dominick Laddy, Mark Rodgers
Publikováno v:
Nature. 577:95-102
Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide1. The only available vaccine, BCG (Bacillus Calmette–Guerin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause o
Autor:
Danilo R. Casimiro, Tsin W. Yeo, Menaka Priyadharsani Rajapakse, Vanessa W. Lim, Bernett Lee, Laura Rivino, Amit Singhal, Bing Lim, Tun-Linn Thein, Thomas Loy, Melissa Hui Yen Chng, Durgalakshmi Sathiakumar, Kalpit A. Vora, Katja Fink, Lisa Tucker-Kellogg, Ying Xiu Toh, Angeline Rouers, Kaval Kaur, Yee Sin Leo, Evan W. Newell
Publikováno v:
Cell Reports Medicine
Cell Reports Medicine, Vol 2, Iss 5, Pp 100278-(2021)
Cell Reports Medicine, Vol 2, Iss 5, Pp 100278-(2021)
Summary Prior immunological exposure to dengue virus can be both protective and disease-enhancing during subsequent infections with different dengue virus serotypes. We provide here a systematic, longitudinal analysis of B cell, T cell, and antibody