Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Danilo Pellin"'
Autor:
Rita Milazzo, Annita Montepeloso, Rajesh Kumar, Francesca Ferro, Eleonora Cavalca, Pietro Rigoni, Paolo Cabras, Yuri Ciervo, Sabyasachi Das, Alessia Capotondo, Danilo Pellin, Marco Peviani, Alessandra Biffi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The conditions supporting the generation of microglia-like cells in the central nervous system (CNS) after transplantation of hematopoietic stem/progenitor cells (HSPC) have been studied to advance the treatment of neurodegenerative disorder
Externí odkaz:
https://doaj.org/article/d7172f4138e44b0280fe830dbc35b4c8
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Background Mathematical models of haematopoiesis can provide insights on abnormal cell expansions (clonal dominance), and in turn can guide safety monitoring in gene therapy clinical applications. Clonal tracking is a recent high-throughput
Externí odkaz:
https://doaj.org/article/f20b5c518eb84fb080b82319e37b4cf2
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101131- (2023)
Ex vivo gene therapy (GT) is a promising treatment for inherited genetic diseases. An ideal transduction protocol should determine high gene marking in long-term self-renewing hematopoietic stem cells (HSCs), preserving their repopulation potential d
Externí odkaz:
https://doaj.org/article/9c5bfeb7143b470b8f0165885ba64a5d
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 28-39 (2023)
Integrating vectors are associated with alterations in cellular function related to disruption of normal gene function. This has been associated with clonal expansion of cells and, in some instances, cancer. These events have been associated with rep
Externí odkaz:
https://doaj.org/article/42f5707d16174ef1bfd32620b4e99f73
Autor:
Jing Zeng, Jerome Ritz, Gabriele Casirati, Andrea Cosentino, Adele Mucci, Mohammed S Mahmoud, Iratxe Ugarte Zabala, Denise Klatt, Christian Brendel, Scott Ficarro, Jarrod Marto, Danilo Pellin, Daniel Bauer, Scott A Armstrong, Pietro Genovese
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/83551a902d254e8c92d56c160fced919
Autor:
Natalia Izotova, Christine Rivat, Cristina Baricordi, Elena Blanco, Danilo Pellin, Eleanor Watt, Athina S. Gkazi, Stuart Adams, Kimberly Gilmour, Jinhua Bayford, Claire Booth, H. Bobby Gaspar, Adrian J. Thrasher, Luca Biasco
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Gene therapy (GT) using haematopoietic stem cells (HSCs) provides an opportunity to trace cell fates in humans, in vivo. Here the authors present evidence in GT patients for a long term lymphoid progenitor population, surviving and maintaining de nov
Externí odkaz:
https://doaj.org/article/dced9d3e9d5c441eaba1bc9789351905
Autor:
Christian Brendel, Olivier Negre, Michael Rothe, Swaroopa Guda, Geoff Parsons, Chad Harris, Meaghan McGuinness, Daniela Abriss, Alla Tsytsykova, Denise Klatt, Martin Bentler, Danilo Pellin, Lauryn Christiansen, Axel Schambach, John Manis, Helene Trebeden-Negre, Melissa Bonner, Erica Esrick, Gabor Veres, Myriam Armant, David A. Williams
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 589-600 (2020)
In this work we provide preclinical data to support initiation of a first-in-human trial for sickle cell disease (SCD) using an approach that relies on reversal of the developmental fetal-to-adult hemoglobin switch. Erythroid-specific knockdown of BC
Externí odkaz:
https://doaj.org/article/7ebf28bc3d664f328d3cea76508fe211
Publikováno v:
Applied Network Science, Vol 4, Iss 1, Pp 1-26 (2019)
Abstract Background During their lifespan, stem- or progenitor cells have the ability to differentiate into more committed cell lineages. Understanding this process can be key in treating certain diseases. However, up until now only limited informati
Externí odkaz:
https://doaj.org/article/50d0f42449524512b7c4f8691d42e93e
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Lymph nodes are key lymphoid organs collecting lymph fluid and migratory cells from the tissue area they survey. When cancerous cells arise within a tissue, the sentinel lymph node is the first immunological organ to mount an immune response. Sub-cap
Externí odkaz:
https://doaj.org/article/31eaaf388924471b98b16fbea5a41ebf
Autor:
Danilo Pellin, Mariana Loperfido, Cristina Baricordi, Samuel L. Wolock, Annita Montepeloso, Olga K. Weinberg, Alessandra Biffi, Allon M. Klein, Luca Biasco
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Human Hematopoietic stem and progenitor cells (HSPCs) are commonly defined by CD34 expression. Here, the authors map single-cell RNA states both inside and outside the CD34 compartment, uncovering previously unappreciated branchpoints and validating
Externí odkaz:
https://doaj.org/article/b4d60ac10b844ab591805a070600b761