Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Danilo Guerini"'
Autor:
Ole Kristian Greiner-Tollersrud, Máté Krausz, Vincent Boehler, Aikaterini Polyzou, Maximilian Seidl, Ambra Spahiu, Zeinab Abdullah, Katarzyna Andryka-Cegielski, Felix Immunuel Dominick, Katrin Huebscher, Andreas Goschin, Cristian R. Smulski, Eirini Trompouki, Regina Link, Hilmar Ebersbach, Honnappa Srinivas, Martine Marchant, Georgios Sogkas, Dieter Staab, Cathrine Vågbø, Danilo Guerini, Sebastian Baasch, Eicke Latz, Gunther Hartmann, Philippe Henneke, Roger Geiger, Xiao P. Peng, Bodo Grimbacher, Eva Bartok, Ingrun Alseth, Max Warncke, Michele Proietti
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114899- (2024)
Summary: Although adenosine deaminase 2 (ADA2) is considered an extracellular ADA, evidence questions the physiological relevance of this activity. Our study reveals that ADA2 localizes within the lysosomes, where it is targeted through modifications
Externí odkaz:
https://doaj.org/article/f6e14d70f0b648c3aca83261512b83d8
Autor:
Merve Mutlu, Isabel Schmidt, Andrew I. Morrison, Benedikt Goretzki, Felix Freuler, Damien Begue, Oliver Simic, Nicolas Pythoud, Erik Ahrne, Sandra Kapps, Susan Roest, Debora Bonenfant, Delphine Jeanpierre, Thi-Thanh-Thao Tran, Rob Maher, Shaojian An, Amandine Rietsch, Florian Nigsch, Andreas Hofmann, John Reece-Hoyes, Christian N. Parker, Danilo Guerini
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Stimulator of interferon genes (STING) is a central component of the cytosolic nucleic acids sensing pathway and as such master regulator of the type I interferon response. Due to its critical role in physiology and its’ involvement in a v
Externí odkaz:
https://doaj.org/article/d64305878b7f4abe9dd92a3040e7b4f4
Autor:
Giulio Morozzi, Julian Rothen, Gauthier Toussaint, Katrina De Lange, Katrin Westritschnig, Arno Doelemeyer, Vanessa Pitiot Ueberschlag, Peter Kahle, Christian Lambert, Michael Obrecht, Nicolau Beckmann, Veronique Ritter, Moh Panesar, Daniela Stauffer, Isabelle Garnier, Matthias Mueller, Danilo Guerini, Caroline Gubser Keller, Judith Knehr, Guglielmo Roma, Michael Bidinosti, Sophie Brachat, Frederic Morvan, Mara Fornaro
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103434- (2021)
Summary: Inflammatory responses are crucial for regeneration following peripheral nerve injury (PNI). PNI triggers inflammatory responses at the site of injury. The DNA-sensing receptor cyclic GMP-AMP synthase (cGAS) and its downstream effector stimu
Externí odkaz:
https://doaj.org/article/34f8e9f03cac483cb7ab6b1f71128e9e
Autor:
Danilo Guerini
Publikováno v:
Cells, Vol 11, Iss 7, p 1159 (2022)
The cGAS STING pathway has received much attention in recent years, and it has been recognized as an important component of the innate immune response. Since the discovery of STING and that of cGAS, many observations based on preclinical models sugge
Externí odkaz:
https://doaj.org/article/2b44de5310fc4a2ba5f0d6f74af0920d
Autor:
Merve Mutlu, Isabel Schmidt, Andrew I. Morrison, Benedikt Goretzki, Felix Freuler, Damien Begue, Nicolas Pythoud, Erik Ahrne, Sandra Kapps, Susan Roest, Debora Bonenfant, Delphine Jeanpierre, Thi-Thanh-Thao Tran, Rob Maher, Shaojian An, Amandine Rietsch, Florian Nigsch, Andreas Hofmann, John Reece-Hoyes, Christian N. Parker, Danilo Guerini
Stimulator of interferon genes (STING) is a central component of the pathway sensing the presence of cytosolic nucleic acids, having a key role in type I interferon innate immune response. Localized at the endoplasmic reticulum (ER), STING becomes ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea2e8d59f2b3487af480f725db360e69
https://doi.org/10.1101/2023.02.08.527642
https://doi.org/10.1101/2023.02.08.527642
Autor:
Sophie Brachat, Danilo Guerini, Nicolau Beckmann, Isabelle Garnier, Veronique Ritter, Vanessa Pitiot Ueberschlag, Daniela Stauffer, Giulio Morozzi, Frederic Morvan, Katrin Westritschnig, Gauthier Toussaint, Julian Rothen, Judith Knehr, Michael Obrecht, Peter Kahle, Michael Bidinosti, Mara Fornaro, Matthias Mueller, Arno Doelemeyer, Katrina De Lange, Caroline Gubser Keller, Moh Panesar, Christian Lambert, Guglielmo Roma
Publikováno v:
iScience
iScience, Vol 24, Iss 12, Pp 103434-(2021)
iScience, Vol 24, Iss 12, Pp 103434-(2021)
Summary Inflammatory responses are crucial for regeneration following peripheral nerve injury (PNI). PNI triggers inflammatory responses at the site of injury. The DNA-sensing receptor cyclic GMP-AMP synthase (cGAS) and its downstream effector stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd7a2ef1b44038de9103a961edc3d92
http://europepmc.org/articles/PMC8633968
http://europepmc.org/articles/PMC8633968
Autor:
Casey J. N. Mathison, Mihai Azimioara, Christopher Cow, Pascal Rigollier, Ursula Bodendorf, Pierre-Yves Michellys, Victor Nikulin, Daniel Pflieger, Ben Wen, Bo Liu, Samantha Zaharevitz, Trixi Brandl, Danilo Guerini, Daniel R. Beisner, Juraj Velcicky, Robert Epple
Publikováno v:
ACS Med Chem Lett
[Image: see text] SPPL2a (Signal Peptide Peptidase Like 2a) is an intramembrane aspartyl protease engaged in the function of B-cells and dendritic cells. Despite being an attractive target for modulation of the immune system, selective SPPL2a inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e450a59020e27f96fb2b86a4f5342a
https://doi.org/10.1021/acsmedchemlett.9b00044
https://doi.org/10.1021/acsmedchemlett.9b00044
Autor:
Amanda Littlewood-Evans, Joschka Willemsen, Thomas Hoyler, Marie-Therese Neuhoff, Clemence Tessier, Juan Zhang, Tara N. Thorsen, Maroof Hasan, Sophie Sarret, James S. Rush, Richard M. Siegel, Emma Noir, Danilo Guerini
Publikováno v:
Cell reports. 37(6)
Tumor necrosis factor (TNF) is a key driver of several inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis, in which affected tissues show an interferon-stimulated gene signature. Here, we demonstrate that T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f390fc90121d892f5efbd86eac953e
https://pubmed.ncbi.nlm.nih.gov/34758308
https://pubmed.ncbi.nlm.nih.gov/34758308
Autor:
Katrin Hübscher, Eirini Trompouki, Danilo Guerini, Roger Geiger, Ole K. Greiner-Tollersrud, Honnappa Srinivas, Sebastian Baasch, Eva Bartok, Hilmar Ebersbach, Salvatore Raieli, Jan Ole Olsen, Martine Marchant, Bodo Grimbacher, Vincent Boehler, Georg Kochs, Aikaterini Polyzou, Regina Link, Cristian R. Smulski, Gunther Hartmann, Máté Krausz, Michele Proietti, Dieter Staab, Maximilian Seidl, Johanna Schepp, Philipp Henneke, Max Warncke
Deficiency of adenosine deaminase 2 (DADA2) is a severe, congenital syndrome, which manifests with hematologic, immunologic and inflammatory pathologies. DADA2 is caused by biallelic mutations in ADA2, but the function of ADA2, and the mechanistic li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26a38fc6bbd8be9ab969f0fdbf4f90d2
https://doi.org/10.1101/2020.06.21.162990
https://doi.org/10.1101/2020.06.21.162990