Application of Transthoracic Echocardiography for Cardiac Safety Evaluation in the Clinical Development Process of Vaccines Against Streptococcus pyogenes

Autor: Usman Nakakana, Alimamy Serry-Bangura, Bassey Effiom Edem, Pietro Tessitore, Leonardo Di Cesare, Danilo Gomes Moriel, Audino Podda, Iris Sarah De Ryck, Ashwani Kumar Arora

Publikováno v: Drugs in R&D, Vol 24, Iss 1, Pp 1-12 (2024)

Abstract Superficial infections with Streptococcus pyogenes (Strep A), pharyngitis and impetigo can induce acute rheumatic fever, an autoimmune sequela manifesting mostly with arthritis and rheumatic carditis. Valvular heart damage can persist or adv

Externí odkaz: https://doaj.org/article/23154e1095a44ff6b94abfb25a71616c

Rational Design of a Glycoconjugate Vaccine against Group A Streptococcus

Autor: Roberta Di Benedetto, Francesca Mancini, Martina Carducci, Gianmarco Gasperini, Danilo Gomes Moriel, Allan Saul, Francesca Necchi, Rino Rappuoli, Francesca Micoli

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 22, p 8558 (2020)

No commercial vaccine is yet available against Group A Streptococcus (GAS), major cause of pharyngitis and impetigo, with a high frequency of serious sequelae in low- and middle-income countries. Group A Carbohydrate (GAC), conjugated to an appropria

Externí odkaz: https://doaj.org/article/5c3fc27067ab478c9ed20f8e446de50d

EsiB, a Novel Pathogenic Escherichia coli Secretory Immunoglobulin A-Binding Protein Impairing Neutrophil Activation

Autor: Ilaria Pastorello, Silvia Rossi Paccani, Roberto Rosini, Rossella Mattera, Mario Ferrer Navarro, Dunja Urosev, Barbara Nesta, Paola Lo Surdo, Mariangela Del Vecchio, Valentina Rippa, Isabella Bertoldi, Danilo Gomes Moriel, Alexander J. Laarman, Jos A. G. van Strijp, Xavier Daura, Mariagrazia Pizza, Laura Serino, Marco Soriani

Publikováno v: mBio, Vol 4, Iss 4 (2013)

ABSTRACT In this study, we have characterized the functional properties of a novel Escherichia coli antigen named EsiB (E. coli secretory immunoglobulin A-binding protein), recently reported to protect mice from sepsis. Gene distribution analysis of

Externí odkaz: https://doaj.org/article/550876e6f66a44ab97c925a0fed52434

FdeC, a Novel Broadly Conserved Escherichia coli Adhesin Eliciting Protection against Urinary Tract Infections

Autor: Barbara Nesta, Glen Spraggon, Christopher Alteri, Danilo Gomes Moriel, Roberto Rosini, Daniele Veggi, Sara Smith, Isabella Bertoldi, Ilaria Pastorello, Ilaria Ferlenghi, Maria Rita Fontana, Gad Frankel, Harry L. T. Mobley, Rino Rappuoli, Mariagrazia Pizza, Laura Serino, Marco Soriani

Publikováno v: mBio, Vol 3, Iss 2 (2012)

ABSTRACT The increasing antibiotic resistance of pathogenic Escherichia coli species and the absence of a pan-protective vaccine pose major health concerns. We recently identified, by subtractive reverse vaccinology, nine Escherichia coli antigens th

Externí odkaz: https://doaj.org/article/2b6beac9d4a94422bfcf7290d1fa17a3

Structure, dynamics and immunogenicity of a catalytically inactive CXC Chemokine-degrading Protease SpyCEP from Streptococcus pyogenes

Autor: Giuliano Bensi, Danilo Gomes Moriel, Stephen Matthews, Guido Grandi, Danuta Mossakowska, Francesca Mancini, Sarah L. Rouse, Yingqi Xu, Max Pearson, Enrico Malito, Emiliano Chiarot, Francesca Micoli, Shiranee Sriskandan, Francesca Abate, Immaculada Margarit, Matthew J. Bottomley, Sophie McKenna, James E. Pease

Publikováno v: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 650-660 (2020)
'Computational and Structural Biotechnology Journal ', vol: 18, pages: 650-660 (2020)

Graphical abstract
Over 18 million disease cases and half a million deaths worldwide are estimated to be caused annually by Group A Streptococcus. A vaccine to prevent GAS disease is urgently needed. SpyCEP (Streptococcus pyogenes Cell-Envelope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc509c7640f9e155434611c67601fb3
http://hdl.handle.net/10044/1/78264