Tropane alkaloids from the stem bark of Erythroxylum bezerrae

Autor: Manoel Odorico M. de Filho, Danilo D. Rocha, Alejandro Ayala, Maria Iracema Bezerra Loiola, Luana San de O. Brito, Edilberto R. Silveira, Francisco das Chagas L. Pinto, Otília Deusdênia L. Pessoa, Kirley Marques Canuto, Maria Fernanda M. Mendoza, Beatriz Pinheiro Bezerra

Publikováno v: Repositório Institucional da Universidade Federal do Ceará (UFC)
Universidade Federal do Ceará (UFC)
instacron:UFC

Six previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0713305c749600266ce372f3b3db84d7
http://www.repositorio.ufc.br/handle/riufc/64080

Action mechanism of naphthofuranquinones against fluconazole-resistant Candida tropicalis strains evidenced by proteomic analysis: The role of increased endogenous ROS

Autor: João Batista de Andrade Neto, Ana Cristina de Oliveira Monteiro Moreira, Anderson Ramos da Silva, Frederico Bruno Mendes Batista Moreno, Hemerson Iuri Ferreira Magalhães, Eufrânio N. da Silva Júnior, Francisca Bruna Stefany Aires do Nascimento, Hélio Vitoriano Nobre Júnior, Danilo D. Rocha, Manoel Odorico de Moraes, Cecília Rocha da Silva, Thalles B. Grangeiro, Rosana de Sousa Campos, Bruno C. Cavalcanti, Maria Aparecida Alexandre Josino, Marina Duarte Pinto Lobo, Letícia Serpa Sampaio, Renato de Azevedo Moreira

Publikováno v: Microbial Pathogenesis. 117:32-42

The increased incidence of candidemia in terciary hospitals worldwide and the cross-resistance frequency require the new therapeutic strategies development. Recently, our research group demonstrated three semi-synthetic naphthofuranquinones (NFQs) wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441952a3db927a961d5379cdad56e313
https://doi.org/10.1016/j.micpath.2017.12.016

Withanolides from leaves of cultivated Acnistus arborescens

Autor: Danilo D. Rocha, Pedro Henrique Jataí Batista, Karísia Sousa Barros de Lima, Letícia V. Costa-Lotufo, Antonio Marcos Esmeraldo Bezerra, Francisco das Chagas L. Pinto, Juliane Lira Tavares, Kirley Marques Canuto, Edilberto R. Silveira, Daniel Esdras de Andrade Uchoa, Otília Deusdênia L. Pessoa

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Seven withanolides, including four previously unknown, were isolated from the acetone and ethanol extracts of cultivated specimens of Acnistus arborescens . These four compounds were identified as rel -(18 R ,22 R )-5 β ,6 β :18 β ,20-diepoxy-3 β

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f023cdb45c2fd3f887ba9112a261776
https://doi.org/10.1016/j.phytochem.2016.07.003

Natural products as new antimitotic compounds for anticancer drug development

Autor: Renan da Silva Santos, Danilo D. Rocha, Sarah Sant’Anna Maranhão, Manoel Odorico de Moraes-Filho, Carlos Roberto Koscky Paier, Kaio Moraes de Farias, Teiliane Rodrigues Carneiro, Cláudia Pessoa, Lídia Moreira Lima

Publikováno v: Clinics; v. 73 n. Suppl. 1 (2018); e813s
Clinics; Vol. 73 Núm. Suppl. 1 (2018); e813s
Clinics; Vol. 73 No. Suppl. 1 (2018); e813s
Clinics
Universidade de São Paulo (USP)
instacron:USP
Clinics, Vol 73, Iss suppl 1 (2018)

Cell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness. Many

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6bbeecec19e955e02edb691cf0274e9
https://pubmed.ncbi.nlm.nih.gov/30540125

Chromomycin A2 Induces Autophagy in Melanoma Cells

Autor: Thiciana S. Sousa, Jesús Martín, Paula C. Jimenez, Letícia V. Costa-Lotufo, Otília Deusdênia L. Pessoa, Danilo D. Rocha, Diego Veras Wilke, Fernando Reyes, Hozana Patrícia S. Freitas, Larissa A. Guimarães

Publikováno v: Marine Drugs
Repositório Institucional da Universidade Federal do Ceará (UFC)
Universidade Federal do Ceará (UFC)
instacron:UFC
Marine Drugs, Vol 12, Iss 12, Pp 5839-5855 (2014)
Volume 12
Issue 12
Pages 5839-5855

The present study highlights the biological effects of chromomycin A2 toward metastatic melanoma cells in culture. Besides chromomycin A2, chromomycin A3 and demethylchromomycin A2 were also identified from the extract derived from Streptomyces sp.,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22364509d8b15333d33de8b80902baf9
http://europepmc.org/articles/PMC4278204