Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Danilo B. Medinas"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/f0516d8f1c8d4c42a9ef06258e5389f9
Autor:
Pablo Rozas, Cristina Pinto, Francisca Martínez Traub, Rodrigo Díaz, Viviana Pérez, Daniela Becerra, Patricia Ojeda, Jorge Ojeda, Madison T. Wright, Jessica Mella, Lars Plate, Juan Pablo Henríquez, Claudio Hetz, Danilo B. Medinas
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects motoneurons. Mutations in superoxide dismutase 1 (SOD1) have been described as a causative genetic factor for ALS. Mice overexpressing ALS-link
Externí odkaz:
https://doaj.org/article/c57fbc2a7aa8401fb63f027829c4e9a4
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/18e6dcae28ea489ab1d4905a78a82560
Autor:
Cristina Pinto, Danilo B. Medinas, Francisco Fuentes-Villalobos, Jaime Maripillán, Ariel F. Castro, Agustín D. Martínez, Nelson Osses, Claudio Hetz, Juan P. Henríquez
Publikováno v:
Neurobiology of Disease, Vol 130, Iss , Pp 104497- (2019)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron death. A 20% of familial ALS cases are associated with mutations in the gene coding for superoxide dismutase 1 (SOD1). The accumulation of abnormal aggre
Externí odkaz:
https://doaj.org/article/4a0d45cd6707447e8bd3fb8034d9623c
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motoneurons and paralysis. The mechanisms underlying neuronal degeneration in ALS are starting to be elucidated, highlighting disturbanc
Externí odkaz:
https://doaj.org/article/1ef3fb0fcdc44aa0a60515850d577e69
Publikováno v:
International Journal of Cell Biology, Vol 2013 (2013)
Amyotrophic lateral sclerosis (ALS) is the most frequent paralytic disease in adults. Most ALS cases are considered sporadic with no clear genetic component. The disruption of protein homeostasis due to chronic stress responses at the endoplasmic ret
Externí odkaz:
https://doaj.org/article/cc604072232247c4b94c189e25c55fdf
Autor:
Claudia Duran-Aniotz, Natalia Poblete, Catalina Rivera-Krstulovic, Álvaro O. Ardiles, Mei Li Díaz-Hung, Giovanni Tamburini, Carleen Mae P. Sabusap, Yannis Gerakis, Felipe Cabral-Miranda, Javier Diaz, Matias Fuentealba, Diego Arriagada, Ernesto Muñoz, Sandra Espinoza, Gabriela Martinez, Gabriel Quiroz, Pablo Sardi, Danilo B. Medinas, Darwin Contreras, Ricardo Piña, Mychael V. Lourenco, Felipe C. Ribeiro, Sergio T. Ferreira, Carlos Rozas, Bernardo Morales, Lars Plate, Christian Gonzalez-Billault, Adrian G. Palacios, Claudio Hetz
Publikováno v:
Molecular Therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c98e87431ed56aa86b106853f2b384b
https://doi.org/10.1016/j.ymthe.2023.03.028
https://doi.org/10.1016/j.ymthe.2023.03.028
Autor:
Felipe Cabral‐Miranda, Giovanni Tamburini, Gabriela Martinez, Alvaro O Ardiles, Danilo B Medinas, Yannis Gerakis, Mei‐Li Diaz Hung, René Vidal, Matias Fuentealba, Tim Miedema, Claudia Duran‐Aniotz, Javier Diaz, Cristobal Ibaceta‐Gonzalez, Carleen M Sabusap, Francisca Bermedo‐Garcia, Paula Mujica, Stuart Adamson, Kaitlyn Vitangcol, Hernan Huerta, Xu Zhang, Tomohiro Nakamura, Sergio Pablo Sardi, Stuart A Lipton, Brian K Kennedy, Juan Pablo Henriquez, J Cesar Cárdenas, Lars Plate, Adrian G Palacios, Claudio Hetz
Publikováno v:
The EMBO Journal. 41
Aging is a major risk factor to develop neurodegenerative diseases and is associated with decreased buffering capacity of the proteostasis network. We investigated the significance of the unfolded protein response (UPR), a major signaling pathway act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474993c75fc394a4e5abf662a623e8f9
https://doi.org/10.15252/embj.2022111952
https://doi.org/10.15252/embj.2022111952
Autor:
Claudia Duran-Aniotz, Catalina Rivera-Krstulovic, Natalia Poblete, Álvaro O. Ardiles, Mei Li Díaz, Carleen Mae P. Sabusap, Yannis Gerakis, Felipe Cabral Miranda, Javier Diaz, Matias Fuentealba, Ernesto Muñoz, Sandra Espinoza, Gabriela Martinez, Gabriel Quiroz, Giovanni Tamburini, Danilo B. Medinas, Darwin Contreras, Ricardo Piña, Mychael V. Lourenco, Felipe C. Ribeiro, Sergio T. Ferreira, Carlos Rozas, Bernardo Morales, Lars Plate, Christian Gonzalez-Billault, Adrian G. Palacios, Claudio Hetz
Alteration in the buffering capacity of the proteostasis network is an emerging feature of Alzheimer’s disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) is the main adaptive pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::375ad74064acffde10be3a7c764e1cb4
https://doi.org/10.1101/2022.06.21.496869
https://doi.org/10.1101/2022.06.21.496869
Publikováno v:
Cells & Development. 170:203781
The development of the central nervous system requires a series of morphogenetic events that shape brain and spinal cord structures. Several brain regions and neural circuits are formed by differential gene expression patterns and cell migration even
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7211497b49bc9bceb7852ba2aa67196b
https://doi.org/10.1016/j.cdev.2022.203781
https://doi.org/10.1016/j.cdev.2022.203781