The memory B cell response to influenza vaccination is impaired in older persons

Autor: Alice R. Burton, Stephane M. Guillaume, William S. Foster, Adam K. Wheatley, Danika L. Hill, Edward J. Carr, Michelle A. Linterman

Publikováno v: Cell Reports, Vol 43, Iss 2, Pp 113745- (2024)

Externí odkaz: https://doaj.org/article/719be920c7a04aaab4b62ce9d5d095b4

Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of γδ T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea

Autor: Louis Schofield, Lisa J. Ioannidis, Stephan Karl, Leanne J. Robinson, Qiao Y. Tan, Daniel P. Poole, Inoni Betuela, Danika L. Hill, Peter M. Siba, Diana S. Hansen, Ivo Mueller, Emily M. Eriksson

Publikováno v: BMC Medicine, Vol 15, Iss 1, Pp 1-15 (2017)

Abstract Background γδ T cells are important for both protective immunity and immunopathogenesis during malaria infection. However, the immunological processes determining beneficial or detrimental effects on disease outcome remain elusive. The aim

Externí odkaz: https://doaj.org/article/9a21a63fa8f94893b24a586214a3aa61

Can follicular helper T cells be targeted to improve vaccine efficacy? [version 1; referees: 3 approved]

Autor: Michelle A. Linterman, Danika L. Hill

Publikováno v: F1000Research, Vol 5 (2016)

The success of most vaccines relies on the generation of antibodies to provide protection against subsequent infection; this in turn depends on a robust germinal centre (GC) response that culminates in the production of long-lived antibody-secreting

Externí odkaz: https://doaj.org/article/723aa30a81f147f78eecf38dd2cc43ed

Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging

Autor: Alyssa Silva-Cayetano, Sigrid Fra-Bido, Philippe A. Robert, Silvia Innocentin, Alice R. Burton, Emily M. Watson, Jia Le Lee, Louise M. C. Webb, William S. Foster, Ross C. J. McKenzie, Alexandre Bignon, Ine Vanderleyden, Dominik Alterauge, Julia P. Lemos, Edward J. Carr, Danika L. Hill, Isabella Cinti, Karl Balabanian, Dirk Baumjohann, Marion Espeli, Michael Meyer-Hermann, Alice E. Denton, Michelle A. Linterman

The magnitude and quality of the germinal center (GC) response decline with age, resulting in poor vaccine-induced immunity in older individuals. A functional GC requires the co-ordination of multiple cell types across time and space, in particular a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6af918521eb723049f1db70982a5b74
http://hdl.handle.net/10044/1/104428

Sec22b is a critical and non-redundant regulator of plasma cell maintenance

Autor: Amélie Bonaud, Laetitia Gargowitsch, Simon M. Gilbert, Elanchezhian Rajan, Pablo Canales-Herrerias, Daniel Stockholm, Nabila F. Rahman, Mark O. Collins, Hakan Taskiran, Danika L. Hill, Andres Alloatti, Nagham Alouche, Stéphanie Balor, Vanessa Soldan, Daniel Gillet, Julien Barbier, Françoise Bachelerie, Kenneth G. C. Smith, Julia Jellusova, Pierre Bruhns, Sebastian Amigorena, Karl Balabanian, Michelle A. Linterman, Andrew A. Peden, Marion Espéli

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (2), pp.e2213056120. ⟨10.1073/pnas.2213056120⟩

Despite the essential role of plasma cells in health and disease, the cellular mechanisms controlling their survival and secretory capacity are still poorly understood. Here, we identified the soluble N-ethylmaleimide-sensitive factor attachment prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f62eb6890c17956c3a9822f5a059b5a
https://hal.science/hal-04064289v1/document