Výsledky vyhledávání - "Danijela Dukovski"

Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR

Autor: Justin Shumate, Emery Smith, John P. Miller, Louis Scampavia, Danijela Dukovski, Timothy P. Spicer

Publikováno v: Slas Discovery

Cystic fibrosis (CF) is caused by a mutation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, which disrupts an ion channel involved in hydration maintenance via anion homeostasis. Nearly 5% of CF patients possess one or more c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684d1f8160b17c93c974005ad2b0fd94
https://doi.org/10.1177/2472555220962001

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Amplifiers co-translationally enhance CFTR biosynthesis via PCBP1-mediated regulation of CFTR mRNA

Autor: Daniel Finley, Danijela Dukovski, J.P. Miller, Cecilia M. Bastos, Jeffery W. Kelly, Richard I. Morimoto, Benito Munoz, Randall W. King, F. Ulrich Hartl, Po Shun Lee, Adriana Villella, Marija Zecevic

Publikováno v: Journal of cystic fibrosis

BACKGROUND: Cystic fibrosis (CF) is a recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. We previously described a first-in-class CFTR modulator that functions as an amplifier to selectively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8d08db66648517be6e46ada5b6addd
https://hdl.handle.net/21.11116/0000-0007-4DBE-E21.11116/0000-0007-4DC1-921.11116/0000-0007-4DC0-A

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Use of a High-Throughput Phenotypic Screening Strategy to Identify Amplifiers, a Novel Pharmacological Class of Small Molecules That Exhibit Functional Synergy with Potentiators and Correctors

Autor: Matthew Cullen, Cecilia M. Bastos, Lawrence Drew, Danijela Dukovski, Benito Munoz, Kenneth A. Giuliano, Shinichiro Wachi, Po-Shun Lee, Sheila Hauck, Olivia Green, Bradley D. Tait, John P. Miller

Publikováno v: Slas Discovery

Cystic fibrosis (CF) is a lethal genetic disorder caused by mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Despite recent groundbreaking approval of genotype-specific small-molecule drugs, a significant portion of CF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0ad75dc6470779f40014d6f7a23b0b
https://doi.org/10.1177/2472555217729790

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CATCHR, HOPS and CORVET tethering complexes share a similar architecture

Autor: Hui-Ting Chou, Karin M. Reinisch, Melissa G. Chambers, Thomas Walz, Danijela Dukovski

Publikováno v: Nature structural & molecular biology

We show that the Saccharomyces cerevisiae GARP complex and the Cog1-4 subcomplex of the COG complex, both members of the complexes associated with tethering containing helical rods (CATCHR) family of multisubunit tethering complexes, share the same s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6f85fb8f5e0172fa519cff824d04c5
https://doi.org/10.1038/nsmb.3264

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Role of Pore-Lining Residues in Defining the Rate of Water Conduction by Aquaporin-0

Autor: Samantha R. Summers, Manish Kumar, Bert L. de Groot, Yu-Shan Hsiao, Shreyas S. Kaptan, Patrick O. Saboe, Danijela Dukovski, Rita De Zorzi, Chiara Rapisarda, Jiaheng Yu, Thomas Walz

Publikováno v: Biophysical Journal

Compared to other aquaporins (AQPs), lens-specific AQP0 is a poor water channel, and its permeability was reported to be pH-dependent. To date, most water conduction studies on AQP0 were performed on protein expressed in Xenopus oocytes, and the resu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0d598c59612ff46ca1b8a5bf529f38
http://www.sciencedirect.com/science/article/pii/S0006349517301480

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The Affinity Grid: A Pre-fabricated EM Grid for Monolayer Purification

Autor: Danijela Dukovski, Deborah F. Kelly, Thomas Walz, Priyanka D. Abeyrathne

Publikováno v: Journal of Molecular Biology. 382:423-433

We have recently developed “monolayer purification” as a rapid and convenient technique to produce specimens of His-tagged proteins or macromolecular complexes for single particle electron microscopy (EM) without prior biochemical purification. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a464c6ff21791f9405cf7412918fb6
https://doi.org/10.1016/j.jmb.2008.07.023

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Monolayer purification: A rapid method for isolating protein complexes for single-particle electron microscopy

Autor: Danijela Dukovski, Deborah F. Kelly, Thomas Walz

Publikováno v: Proceedings of the National Academy of Sciences. 105:4703-4708

Visualizing macromolecular complexes by single-particle electron microscopy (EM) entails stringent biochemical purification, specimen preparation, low-dose imaging, and 3D image reconstruction. Here, we introduce the “monolayer purification” meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59964624aeec6881e9f32c95940c1c9
https://doi.org/10.1073/pnas.0800867105

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Flowering induction of Guzmania by ethylene

Autor: Danijela Dukovski, Robert Bernatzky, Susan S. Han

Publikováno v: Scientia Horticulturae. 110:104-108

Ethylene exposure time required to induce flowering of Guzmania lingulata Mez. ‘Anita’ was investigated by exposing plants to ethylene at 100 μl l −1 for 4, 6, 8, 10, 12, 16, or 24 h. Plants were also exposed to ethylene-free air for the same

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f29f4e211e3dfd818b386e0c942d78a7
https://doi.org/10.1016/j.scienta.2006.05.004

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