Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Daniil Shabashvili"'
Autor:
Maria V. Guijarro, Patrick C. Kellish, Peter E. Dib, Nicholas G. Paciaroni, Akbar Nawab, Jacob Andring, Lidia Kulemina, Nicholas V. Borrero, Carlos Modenutti, Michael Feely, Elham Nasri, Robert P. Seifert, Xiaoping Luo, Richard L. Bennett, Daniil Shabashvili, Jonathan D. Licht, Robert McKenna, Adrian Roitberg, Robert W. Huigens III, Frederic J. Kaye, Maria Zajac-Kaye
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
Although thymidylate synthase (TYMS) inhibitors have served as components of chemotherapy regimens, the currently available inhibitors induce TYMS overexpression or alter folate transport/metabolism feedback pathways that tumor cells exploit for drug
Externí odkaz:
https://doaj.org/article/880157298af5466e978ad20aa4f783da
Publikováno v:
Cancer Research. 81:254-263
In the last decade, large-scale genomic studies in patients with hematologic malignancies identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de novo DNA methyltransferase DNMT3A has emerged as one of the most freq
Autor:
Jonathan D. Licht, Daphné Dupéré-Richer, Huanzhou Xu, Kartika Venugopal, Yang Feng, Richard L. Bennett, Brian K. Law, Heidi L. Casellas Roman, Luisa M Posada, Alberto Riva, Rene Opavsky, Daniil Shabashvili, Kathryn I. Krajcik, Prabhjot Kaur, Chamara Gunaratne, Pawel Nowialis, Christopher R. Cogle, Zachary Zaroogian, Santhi Pondugula, Jianping Li, Jonathan E. Bird, Christina Taragjini, Philipp B. Staber, Olga A. Guryanova, Sumita Bhaduri-McIntosh, Stefan Kubicek, Cassandra M. Berntsen
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 28(4)
Purpose: In acute myeloid leukemia (AML), recurrent DNA methyltransferase 3A (DNMT3A) mutations are associated with chemoresistance and poor prognosis, especially in advanced-age patients. Gene-expression studies in DNMT3A-mutated cells identified si
Autor:
Santhi Pondugula, Brian K. Law, C. Taragjini, Pawel Nowialis, Stefan Kubicek, Cassandra M. Berntsen, Jennifer W Li, Chamara Gunaratne, Philipp B. Staber, Kartika Venugopal, Daniil Shabashvili, Olga A. Guryanova, Luisa M Posada, Yang Feng, Richard L. Bennett, Kathryn I. Krajcik, Zachary Zaroogian, Jonathan E. Bird, H. L. Casellas-Roman, Christopher R. Cogle, Alberto Riva, Rene Opavsky, Daphné Dupéré-Richer, Jonathan D. Licht
Mutations in the DNA methyltransferase 3A (DNMT3A) gene are recurrent in de novo acute myeloid leukemia (AML) and are associated with resistance to standard chemotherapy, disease relapse, and poor prognosis, especially in advanced-age patients. Previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb17d225c80d17824ed4120ca03f89cb
https://doi.org/10.1101/2021.05.28.445639
https://doi.org/10.1101/2021.05.28.445639
Autor:
Maria V. Guijarro, Patrick C. Kellish, Peter E. Dib, Nicholas G. Paciaroni, Akbar Nawab, Jacob Andring, Lidia Kulemina, Nicholas V. Borrero, Carlos Modenutti, Richard L. Bennett, Daniil Shabashvili, Jonathan D. Licht, Robert McKenna, Adrian Roitberg, Robert W. Huigens, Frederic J. Kaye, Maria Zajac-Kaye
Publikováno v:
Cancer Research. 82:4055-4055
Thymidylate synthase (TS) inhibitors are an integral component of chemotherapy regimens for difficult to treat cancer subtypes. Despite initial therapeutic benefit, current inhibitors induce TS overexpression or alter folate transport metabolism feed
Publikováno v:
Cancer Res
In the last decade, large-scale genomic studies in patients with hematologic malignancies identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de novo DNA methyltransferase DNMT3A has emerged as one of the most freq
Autor:
Daniil Shabashvili, Yang Feng, Kartika Venugopal, Luisa M Posada, Jianping Li, Heidi L. Casellas Roman, Olga A. Guryanova
Publikováno v:
Leuk Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e8b9d5262a32188bcd81d91d9a8501
https://europepmc.org/articles/PMC7481860/
https://europepmc.org/articles/PMC7481860/
Autor:
Daniil Shabashvili, Kartika Venugopal, Cassandra M. Berntsen, Chamara Gunaratne, Yang Feng, Olga A. Guryanova, Zachary Zaroogian, Santhi Pondugula
Publikováno v:
Blood. 138:2151-2151
Mutations in DNA damage regulators and epigenetic modifier genes including those in DNA methyltransferase 3A (DNMT3A) are common in pre-malignant clonal hematopoiesis (CH) and are recurrent in myeloid malignancies such as myelodysplastic syndromes (M
Autor:
Robert L. Bowman, Christian Jobin, Kendra Hall, Zachary Zaroogian, Chamara Gunaratne, Kartika Venugopal, Ross L. Levine, Daniil Shabashvili, Alberto Riva, Olga A. Guryanova, Heidi L. Casellas Roman, Rachel C. Newsome, Dorina Avram, Yang Feng, Ashley N. Zuniga, Daniel Kopinke, Cassandra Bernsten, Kathryn I. Krajcik, Troy Robinson
Publikováno v:
Blood. 138:2161-2161
Clonal hematopoiesis (CH) is a condition wherein hematopoietic stem cells (HSCs) acquire mutations, often in presumed leukemia driver genes such as in DNMT3A, leading to clonal dominance and disproportionate contribution to peripheral blood without o
Autor:
Olga A Guryanova, Yang Feng, Rachel Newsome, Troy Robinson, Robert Bowman, Ashley Zuniga, Kendra Hall, Cassandra Berntsen, Daniil Shabashvili, Ross Levine, Alberto Riva, Christian Jobin, Dorina Avram
Publikováno v:
Experimental Hematology. 100:S50