Hydrogen–Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling

Autor: Adam R. Offenbacher, Shenshen Hu, Erin M. Poss, Cody A. M. Carr, Alexander D. Scouras, Daniil M. Prigozhin, Anthony T. Iavarone, Ali Palla, Tom Alber, James S. Fraser, Judith P. Klinman

Publikováno v: ACS Central Science, Vol 3, Iss 6, Pp 570-579 (2017)

Externí odkaz: https://doaj.org/article/9e694d41cae949cb94870565b513e6ae

Majority of the highly variable NLRs in maize share genomic location and contain additional target-binding domains

Autor: Daniil M. Prigozhin, Sanjay Rangavajjhala, Ksenia V. Krasileva

Nucleotide-binding Leucine Rich Repeat proteins (NLRs) are a major class of immune receptors in plants. NLRs include both conserved and rapidly evolving members, however their evolutionary trajectory in crops remains understudied. Availability of cro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1edeae9d898de9f03f5bc5653314cdb
https://doi.org/10.1101/2022.10.05.510735

Clinical and functional heterogeneity associated with the disruption of Retinoic Acid Receptor beta

Autor: Véronique Caron, Nicolas Chassaing, Nicola Ragge, Felix Boschann, Angelina My-Hoa Ngu, Elisabeth Meloche, Sarah Chorfi, Saquib A. Lakhani, Weizhen Ji, Laurie Steiner, Julien Marcadier, Philip R. Jansen, Laura A. van de Pol, Johanna M. van Hagen, Alvaro Serrano Russi, Gwenaël Le Guyader, Magnus Nordenskjöld, Ann Nordgren, Britt-Marie Anderlid, Julie Plaisancié, Corinna Stoltenburg, Denise Horn, Anne Drenckhahn, Fadi F. Hamdan, Mathilde Lefebvre, Tania Attie-Bitach, Peggy Forey, Vasily Smirnov, Françoise Ernould, Marie-Line Jacquemont, Sarah Grotto, Alberto Alcantud, Alicia Coret, Rosario Ferrer-Avargues, Siddharth Srivastava, Catherine Vincent-Delorme, Shelby Romoser, Nicole Safina, Dimah Saade, James R. Lupski, Daniel G. Calame, David Geneviève, Nicolas Chatron, Caroline Schluth-Bolard, Kenneth A. Myers, William B. Dobyns, Patrick Calvas, Caroline Salmon, Richard Holt, Frances Elmslie, Marc Allaire, Daniil M. Prigozhin, André Tremblay, Jacques L. Michaud

Publikováno v: The DDD study 2023, ' Clinical and functional heterogeneity associated with the disruption of retinoic acid receptor beta ', Genetics in Medicine, vol. 25, no. 8, 100856 . https://doi.org/10.1016/j.gim.2023.100856
Genetics in Medicine, 25(8):100856. Lippincott Williams and Wilkins

Purpose: Dominant variants in the retinoic acid receptor beta (RARB) gene underlie a syndromic form of microphthalmia, known as MCOPS12, which is associated with other birth anomalies and global developmental delay with spasticity and/or dystonia. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20681a78b2c744a3e6e6190d86d13ec
https://doi.org/10.1016/j.gim.2023.100856

Crystal Structure and Mechanistic Molecular Modeling Studies of Mycobacterium tuberculosis Diterpene Cyclase Rv3377c

Autor: Jacob E. Corn, Frank DiMaio, Tom Alber, Daniil M. Prigozhin, Yue Zhang, Terrence E. O’Brien, Dean J. Tantillo, Lisa M. Prach, Justin B. Siegel

Publikováno v: Biochemistry, vol 59, iss 47

Terpenes make up the largest class of natural products, with extensive chemical and structural diversity. Diterpenes, mostly isolated from plants and rarely prokaryotes, exhibit a variety of important biological activities and valuable applications,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d6f8982da4f2c4677d4a11206a9202
https://doi.org/10.1021/acs.biochem.0c00762

A Zika virus mutation enhances transmission potential and confers escape from protective dengue virus immunity

Autor: Jose Angel Regla-Nava, Ying-Ting Wang, Camila R. Fontes-Garfias, Yang Liu, Thasneem Syed, Mercylia Susantono, Andrew Gonzalez, Karla M. Viramontes, Shailendra Kumar Verma, Kenneth Kim, Sara Landeras-Bueno, Chun-Teng Huang, Daniil M. Prigozhin, Joseph G. Gleeson, Alexey V. Terskikh, Pei-Yong Shi, Sujan Shresta

Publikováno v: Cell reports, vol 39, iss 2

Zika virus (ZIKV) and dengue virus (DENV) are arthropod-borne pathogenic flaviviruses that co-circulate in many countries. To understand some of the pressures that influence ZIKV evolution, we mimic the natural transmission cycle by repeating serial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a107c47fae1a3447a516fcc941373f
https://pubmed.ncbi.nlm.nih.gov/35417697