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Optimizing the radiosynthesis of [ ⁶⁸ Ga]DOTA-MLN6907 peptide containing three disulfide cyclization bonds - a GCC specific chelate for clinical radiopharmaceuticals.

Autor: Ghai A; Department of Nuclear Medicine, Postgraduate Institute of Medical Education & Research, Sector 12, Chandigarh 160012, India., Singh B; Department of Nuclear Medicine, Postgraduate Institute of Medical Education & Research, Sector 12, Chandigarh 160012, India., Li M; Department of Radiology, The University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA; Departments of Radiation Oncology (Free Radical and Radiation Biology Program), Pediatrics, and Chemistry, and the Interdisciplinary Program in Human Toxicology, The University of Iowa, 500 N Road, ML B180, FRRB, Iowa City, IA, USA., Daniels TA; Radiopharmaceutical Sciences, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA., Coelho R; InviCRO, LLC, 27 Drydock Avenue, Boston, MA 02210 , USA., Orcutt K; InviCRO, LLC, 27 Drydock Avenue, Boston, MA 02210 , USA., Watkins GL; Department of Radiology, The University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA., Norenberg JP; Radiopharmaceutical Sciences, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA., Cvet D; Takeda Pharmaceuticals, 40 Landsdowne Street, Cambridge, MA 02139, USA., Schultz MK; Department of Radiology, The University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA; Departments of Radiation Oncology (Free Radical and Radiation Biology Program), Pediatrics, and Chemistry, and the Interdisciplinary Program in Human Toxicology, The University of Iowa, 500 N Road, ML B180, FRRB, Iowa City, IA, USA. Electronic address: michael-schultz@uiowa.edu.

Publikováno v: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2018 Oct; Vol. 140, pp. 333-341. Date of Electronic Publication: 2018 Aug 09.