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of 4
pro vyhledávání: '"Danielle Verniers"'
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 85:556-561
The potent antidepressant effect of moclobemide, a selective and reversible type A monoamine oxidase (MAO) inhibitor, is clinically established. In view of the ongoing debate on the neuroprotective properties of MAO inhibitors, the present study was
Autor:
Jean-Marie Gillardin, Philippe Girard, Yannick Pansart, Danielle Verniers, Marie-Claude Coppé
Publikováno v:
Pharmacological Research. 54:195-202
The non-opiate analgesic nefopam has been shown to inhibit monoamines uptake, but little is known about receptor subtypes effectively involved in its analgesic effect. In vitro binding assays yielded the following measures of affinity (IC(50)): serot
Autor:
Jean-Marie Gillardin, Yannick Pansart, Philippe Girard, Marie-Claude Coppé, Danielle Verniers
Publikováno v:
European journal of pharmacology. 584(2-3)
Combinations of analgesics with different mechanisms of action offer the possibility of efficient analgesia with a decrease in side effects as a result of reduced dosages of one or both compounds. Based on a clinical observation of synergism between
Autor:
Danielle Verniers, Yannick Pansart, Philippe Girard, Jean-Marie Gillardin, Marie-Claude Coppé
Publikováno v:
European journal of pharmacology. 503(1-3)
The present study explored the role of the histaminergic system in nefopam analgesia based on the structural relationship between nefopam and diphenhydramine. In vitro binding assays revealed that nefopam possesses moderate affinity for histamine H1