Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Danielle Ulanet"'
Autor:
Meredith S. Pelster, Ian M. Silverman, Joseph D. Schonhoft, Adrienne Johnson, Pier Selenica, Danielle Ulanet, Victoria Rimkunas, Jorge S. Reis-Filho
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-7 (2024)
Abstract Pancreatic acinar cell carcinoma (PACC) is a rare form of pancreatic cancer that commonly harbors targetable alterations, including activating fusions in the MAPK pathway and loss-of-function (LOF) alterations in DNA damage response/homologo
Externí odkaz:
https://doaj.org/article/28525c8399254240bf4adf2e72e958ea
Autor:
Timothy A. Yap, Siddhartha Yadav, Benjamin Herzberg, Benedito A. Carneiro, Elisa Fontana, Martin Højgaard, Michael J. Pishvaian, Ruth Plummer, Theresa L. Werner, Vaibhav Sahai, Stephanie Lheureux, Elizabeth K. Lee, Niharika B. Mettu, Gregory M. Cote, Joseph D. Schonhoft, Victoria Rimkunas, Ian M. Silverman, Marisa Wainszelbaum, Gerson Peltz, Adrian J. Fretland, Kezhen Fei, Danielle Ulanet, Insil Kim, Maria Koehler, Ezra Rosen, Michael Cecchini
Publikováno v:
Cancer Research. 83:CT018-CT018
Introduction: ATRi and PARPi combinations kill tumor cells via synergistic modulation of complementary DDR pathways but clinical utility is limited by overlapping toxicities. A genome-wide CRISPR-Cas9 screen identified DDR alterations that sensitize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5440534684331a320c7059e7bfb12f85
https://doi.org/10.1158/1538-7445.am2023-ct018
https://doi.org/10.1158/1538-7445.am2023-ct018
Autor:
Lorey K. Smith, Gabrielle McDonald, Joan So, Lev Kats, Simon J. Hogg, Alexander C Lewis, Lizzy Pijpers, Kym Stanley, Stephin J. Vervoort, Danielle Ulanet, Pilar M. Dominguez, Emily Gruber, Ricky W. Johnstone, Josh Murtie
The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes one of the rate-limiting steps in de novo pyrimidine biosynthesis, a pathway that provides essential metabolic precursors for nucleic acids, glycoproteins and phospholipids. DHOD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::240c83022674d62b7d681315d6c9ddb0
https://doi.org/10.1101/2021.09.24.461627
https://doi.org/10.1101/2021.09.24.461627
Autor:
Timothy A. Yap, Ian M. Silverman, Elisa Fontana, Elizabeth Lee, David Spigel, Martin Højgaard, Stephanie Lheureux, Niharika Mettu, Benedito A. Carneiro, Louise Carter, Ruther Plummer, Joseph D. Schonhoft, Danielle Ulanet, Parham Nejad, Peter Manley, Jorge S. Reis-Filho, Yi Xu, Victoria Rimkunas, Maria Koehler, Ezra Rosen
Publikováno v:
Cancer Research. 82:CT030-CT030
Background: RP-3500 is a potent, oral ATRi developed to treat tumors with LOF gene alterations predicted to exhibit synthetic lethality with ATRi (STEP2 genes). Biomarker analyses from TRESR (NCT04497116) identified predictors of sensitivity to RP-35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6a009f2afb56d51c2d01e1ef25e5096
https://doi.org/10.1158/1538-7445.am2022-ct030
https://doi.org/10.1158/1538-7445.am2022-ct030
Autor:
Ezra Rosen, Ian M. Silverman, Elisa Fontana, Elizabeth Katherine Lee, David R. Spigel, Martin Højgaard, Stephanie Lheureux, Niharika B. Mettu, Benedito A. Carneiro, Louise Carter, Elizabeth Ruth Plummer, Joseph D. Schonhoft, Danielle Ulanet, Peter Manley, Jorge S. Reis-Filho, Yi Xu, Victoria Rimkunas, Maria Koehler, Timothy A. Yap
Publikováno v:
Journal of Clinical Oncology. 40:3082-3082
3082 Background: RP-3500 is a selective and potent oral ATRi in development for advanced solid tumors harboring loss-of-function (LOF) alterations in genes associated with ATRi sensitivity. We determined whether ctDNA can facilitate enrollment/monito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b72f450d9c06c19515f7170d676904af
https://doi.org/10.1200/jco.2022.40.16_suppl.3082
https://doi.org/10.1200/jco.2022.40.16_suppl.3082
Autor:
K. Satish Reddy, Scott A. Biller, Kavitha Nellore, Siva Sanjeeva Rao, Anil K. Padyana, Georg Lenz, Thomas Antony, Charles Locuson, Jonathan Hurov, Mya Steadman, Tabea Erdmann, Mark Fletcher, Zi Peng Fan, Kevin Truskowski, Sreevalsam Gopinath, Alan Mann, Danielle Ulanet, Rohini Narayanaswamy, Sebastien Ronseaux, Gabrielle McDonald, Sung Choe, Zhihua Sui, John Coco, Lenny Dang, Kevin Marks, Victor Chubukov, Erin Artin, Sebastian Hayes, Josh Murtie, Lei Jin, Nelamangala Nagaraja, Hosahalli Subramanya, Sunil Kumar Panigrahi
Publikováno v:
Molecular cancer therapeutics. 19(12)
Agents targeting metabolic pathways form the backbone of standard oncology treatments, though a better understanding of differential metabolic dependencies could instruct more rationale-based therapeutic approaches. We performed a chemical biology sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4f845cc62e9703a40911be67f90bd8
https://pubmed.ncbi.nlm.nih.gov/33082276
https://pubmed.ncbi.nlm.nih.gov/33082276
Autor:
Timothy Yap, Elizabeth Lee, David Spigel, Elisa Fontana, Martin Højgaard, Stephanie Lheureux, Niharika B. Mettu, Louise Carter, Ruth Plummer, Danielle Ulanet, Peter Manley, Ying Jiang, Ezra Rosen
Publikováno v:
Molecular Cancer Therapeutics. 20:CC04-01
Background: RP-3500 is a novel potent and selective ATRi. A genome-wide CRISPR/Cas9-based screening platform (SNIPRx) was utilized to identify and validate synthetic lethal (SL) genomic alterations that predict sensitivity to RP-3500. This is the fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a737a595ed0a7c9420b0f22519e9a4e9
https://doi.org/10.1158/1535-7163.targ-21-cc04-01
https://doi.org/10.1158/1535-7163.targ-21-cc04-01
Autor:
Erin Artin, Lingling Huang, Joshua Murtie, Danielle Ulanet, Giovanni Cianchetta, Zi Peng Fan, Jinmin Ren, Eric L. Allen, Michelle Clasquin, David Pirman, Ying Chen, Christopher E. Mahoney, Sung Choe, Gromoslaw A. Smolen, Yaguang Si, Marion Dorsch, Shengfang Jin, John Coco
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 876-890 (2016)
SummaryAlthough aberrant metabolism in tumors has been well described, the identification of cancer subsets with particular metabolic vulnerabilities has remained challenging. Here, we conducted an siRNA screen focusing on enzymes involved in the tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1abfa7781529d89e5650e094709755a
http://www.sciencedirect.com/science/article/pii/S2211124716312918
http://www.sciencedirect.com/science/article/pii/S2211124716312918
Autor:
Danielle Ulanet, Qi Zhang, Hagop M. Kantarjian, Joshua Murtie, Natalia Baran, Marina Konopleva, Antonio Cavazos, Vinitha Mary Kuruvilla, Philip L. Lorenzi, Michael Andreeff, Zhihong Zeng, Courtney D. DiNardo, Sergej Konoplev
Publikováno v:
Blood. 134:3911-3911
Background: Acute myeloid leukemia (AML) is a devastating hematopoietic malignancy caused by differentiation arrest and suppression of apoptosis of immature myeloid cells. The long-term survival of AML under the established therapies remains poor. Di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac259b1605ffc5595cd425d9ac026174
https://doi.org/10.1182/blood-2019-125469
https://doi.org/10.1182/blood-2019-125469
Autor:
Bijal D. Shah, Scott F. Huntington, Michelle Mobilia, Ajay K. Gopal, Huansheng Xu, Avyakta Kallam, Feng Yin, Danielle Ulanet, John P. Leonard, Gottfried von Keudell, Michael Cooper, Frank G. Basile
Publikováno v:
Blood. 134:1286-1286
Background: Dihydroorotate dehydrogenase (DHODH) is a mitochondrial enzyme involved in the de novo synthesis of pyrimidines, key building blocks for RNA and DNA biosynthesis. Inhibitors of DHODH are currently in clinical use for the treatment of rheu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af910eb7ba9ef2d3bab338cdbc7792cf
https://doi.org/10.1182/blood-2019-123420
https://doi.org/10.1182/blood-2019-123420