Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Danielle Springer"'
Autor:
Chi Ma, Tim F Greten, Firouzeh Korangy, Benjamin L Green, Benjamin Ruf, Mohamed-Reda Benmebarek, Yuta Myojin, Jonathan Qi, Simon Wabitsch, Amran Nur, Kylynda C Bauer, Rajiv Trehan, Danielle Springer, Audrey Noguchi, Morteza Peiravi, Heather Potts
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/6d696f0757554567bc25be120834fb8e
Autor:
Russell H. Knutsen, Leah M. Gober, Elise K. Kronquist, Maninder Kaur, Danielle R. Donahue, Danielle Springer, Zu Xi Yu, Marcus Y. Chen, Yi-Ping Fu, Feri Choobdar, My-Le Nguyen, Sharon Osgood, Joy L. Freeman, Neelam Raja, Mark D. Levin, Beth A. Kozel
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundWilliams Beuren syndrome (WBS) is a recurrent microdeletion disorder that removes one copy of elastin (ELN), resulting in large artery vasculopathy. Early stenosis of the pulmonary vascular tree is common, but few data are available on long
Externí odkaz:
https://doaj.org/article/c78ace6652984ae09c04d4d5b7428a7c
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
While fatty acid metabolism is altered under physiological conditions, alterations can also be maladaptive in diseases such as diabetes and heart failure. Peroxisome Proliferator Activated Receptor α (PPARα) is a transcription factor that regulates
Externí odkaz:
https://doaj.org/article/02859b4478474a58939d88c303dd4a31
Autor:
Ki-Sun Park, Beenish Rahat, Hyung Chul Lee, Zu-Xi Yu, Jacob Noeker, Apratim Mitra, Connor M Kean, Russell H Knutsen, Danielle Springer, Claudia M Gebert, Beth A Kozel, Karl Pfeifer
Publikováno v:
eLife, Vol 10 (2021)
Maternal loss of imprinting (LOI) at the H19/IGF2 locus results in biallelic IGF2 and reduced H19 expression and is associated with Beckwith–-Wiedemann syndrome (BWS). We use mouse models for LOI to understand the relative importance of Igf2 and H1
Externí odkaz:
https://doaj.org/article/9585b4d7825b4eb19926c26cb2be1f3c
Autor:
Junhui Sun, Weidong Hao, Natasha Fillmore, Hanley Ma, Danielle Springer, Zu‐Xi Yu, Agnieszka Sadowska, Andrew Garcia, Ruoyan Chen, Vanessa Muniz‐Medina, Kim Rosenthal, Jia Lin, Denison Kuruvilla, Jane Osbourn, Sotirios K. Karathanasis, Jill Walker, Elizabeth Murphy
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 24 (2019)
Background Heart failure is one of the leading causes of death in Western countries, and there is a need for new therapeutic approaches. Relaxin‐2 is a peptide hormone that mediates pleiotropic cardiovascular effects, including antifibrotic, angiog
Externí odkaz:
https://doaj.org/article/c5f74268cf9e4cc6a8104908bee069d8
Autor:
Jaroslawna Meister, Derek B J Bone, Grzegorz Godlewski, Ziyi Liu, Regina J Lee, Sergey A Vishnivetskiy, Vsevolod V Gurevich, Danielle Springer, George Kunos, Jürgen Wess
Publikováno v:
PLoS Genetics, Vol 15, Iss 10, p e1008424 (2019)
Type 2 diabetes (T2D) has become a major health problem worldwide. Skeletal muscle (SKM) is the key tissue for whole-body glucose disposal and utilization. New drugs aimed at improving insulin sensitivity of SKM would greatly expand available therape
Externí odkaz:
https://doaj.org/article/f1ec279c35aa4678b666611bb8948281
Autor:
Josephine Harrington, Natasha Fillmore, Shouguo Gao, Yanqin Yang, Xue Zhang, Poching Liu, Andrea Stoehr, Ye Chen, Danielle Springer, Jun Zhu, Xujing Wang, Elizabeth Murphy
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 8 (2017)
BackgroundHeart failure preceded by hypertrophy is a leading cause of death, and sex differences in hypertrophy are well known, although the basis for these sex differences is poorly understood. Methods and ResultsThis study used a systems biology ap
Externí odkaz:
https://doaj.org/article/6d1f78a1b6c547c9888345f132b16a08
Autor:
Yingfan Zhang, T. Bradley Willingham, Laura Reyes, Chengyu Liu, Danielle Springer, Audrey Noguchi, Angel M. Aponte, Jeeva Munasinghe, Raul Covian, Brian Glancy
Depletion of transmembrane protein 65 (TMEM65) in a patient with a homozygous point mutation in the TMEM65 gene splice site was reported to result in mitochondrial dysfunction and severe encephalomyopathy(1), indicating the clinical importance of TME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d00932474052bdc5591e0a48e335f116
https://doi.org/10.1101/2022.08.02.502535
https://doi.org/10.1101/2022.08.02.502535
Autor:
Basil McIntosh, Russell Knutsen, Mark Levin, Yi‐Ping Fu, Danielle Springer, Elise Kronquist, Christopher Pai, Robert Heuckeroth, Beth Kozel
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36
BAZ1B is one of several genes deleted in Williams-Beuren Syndrome (WBS), a complex, multisystem genetic condition that occurs in ~1 in 8000 live births. Also known as Williams Syndrome Transcription Factor (WSTF), BAZ1B is thought to be essential for
Publikováno v:
PloS one. 17(3)
While fatty acid metabolism is altered under physiological conditions, alterations can also be maladaptive in diseases such as diabetes and heart failure. Peroxisome Proliferator Activated Receptor α (PPARα) is a transcription factor that regulates