Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin

Autor: Koen Schipper, Danielle Seinstra, Anne Paulien Drenth, Eline van der Burg, Veronika Ramovs, Arnoud Sonnenberg, Jacco van Rheenen, Micha Nethe, Jos Jonkers

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

E-cadherin is a well-known tumor suppressor albeit loss of E-cadherin alone is insufficient to induce mammary tumorigenesis. Here the authors report that epithelial cells that have lost E-cadherin can survive by extruding to the basal lamina but requ

Externí odkaz: https://doaj.org/article/db63cd2a463f498782159daf9e40c722

Supplementary Table from Differential Survival and Therapy Benefit of Patients with Breast Cancer Are Characterized by Distinct Epithelial and Immune Cell Microenvironments

Autor: Jacco van Rheenen, Sabine C. Linn, Alexander van Oudenaarden, Hendrika M. Oosterkamp, Marleen Kok, Lodewyk F.A. Wessels, Emile E. Voest, Jelle Wesseling, Hugo M. Horlings, Emiel J. Rutgers, Sandra D. Bakker, Monique E.M.M. Bos, Johanneke E.A. Portielje, Alex L.T. Imholz, Harm van Tinteren, Sander Canisius, A. Elise van Leeuwen-Stok, Ingrid A.M. Mandjes, Ester H. Lips, Iris Nederlof, Kerstin Hahn, Erik van Werkhoven, Mark Opdam, Daphne van der Velden, Marlous Hoogstraat, Claire Vennin, Annelot G.J. van Rossum, Danielle Seinstra, Lennart Kester

Supplementary Table from Differential Survival and Therapy Benefit of Patients with Breast Cancer Are Characterized by Distinct Epithelial and Immune Cell Microenvironments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021b76679770c8c8cdc04914e67b7d73
https://doi.org/10.1158/1078-0432.22482795.v1

Data from Differential Survival and Therapy Benefit of Patients with Breast Cancer Are Characterized by Distinct Epithelial and Immune Cell Microenvironments

Autor: Jacco van Rheenen, Sabine C. Linn, Alexander van Oudenaarden, Hendrika M. Oosterkamp, Marleen Kok, Lodewyk F.A. Wessels, Emile E. Voest, Jelle Wesseling, Hugo M. Horlings, Emiel J. Rutgers, Sandra D. Bakker, Monique E.M.M. Bos, Johanneke E.A. Portielje, Alex L.T. Imholz, Harm van Tinteren, Sander Canisius, A. Elise van Leeuwen-Stok, Ingrid A.M. Mandjes, Ester H. Lips, Iris Nederlof, Kerstin Hahn, Erik van Werkhoven, Mark Opdam, Daphne van der Velden, Marlous Hoogstraat, Claire Vennin, Annelot G.J. van Rossum, Danielle Seinstra, Lennart Kester

Purpose:Extensive work in preclinical models has shown that microenvironmental cells influence many aspects of cancer cell behavior, including metastatic potential and their sensitivity to therapeutics. In the human setting, this behavior is mainly c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da2ff38eb6c3e54d9efc292232c0a49
https://doi.org/10.1158/1078-0432.c.6530997.v1

Epithelial-to-Mesenchymal Transition Drives Invasiveness of Breast Cancer Brain Metastases

Autor: Andreia S. Margarido, Rebeca Uceda-Castro, Kerstin Hahn, Roebi de Bruijn, Lennart Kester, Ingrid Hofland, Jeroen Lohuis, Danielle Seinstra, Annegien Broeks, Jos Jonkers, Marike L. D. Broekman, Pieter Wesseling, Claire Vennin, Miguel Vizoso, Jacco van Rheenen

Publikováno v: Margarido, A S, Uceda-Castro, R, Hahn, K, de Bruijn, R, Kester, L, Hofland, I, Lohuis, J, Seinstra, D, Broeks, A, Jonkers, J, Broekman, M L D, Wesseling, P, Vennin, C, Vizoso, M & van Rheenen, J 2022, ' Epithelial-to-Mesenchymal Transition Drives Invasiveness of Breast Cancer Brain Metastases ', Cancers, vol. 14, no. 13, 3115 . https://doi.org/10.3390/cancers14133115
Cancers; Volume 14; Issue 13; Pages: 3115
Cancers, 14(13):3115. Multidisciplinary Digital Publishing Institute (MDPI)

(1) Background: an increasing number of breast cancer patients develop lethal brain metastases (BM). The complete removal of these tumors by surgery becomes complicated when cells infiltrate into the brain parenchyma. However, little is known about t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbb87842d58808de77f2e11796cb6e3
https://research.vumc.nl/en/publications/0787a063-65b2-432b-b832-a08de55048f5

Fsp1-Mediated Lineage Tracing Fails to Detect the Majority of Disseminating Cells Undergoing EMT

Autor: Saskia I.J. Ellenbroek, Laura Bornes, Danielle Seinstra, Jacco van Rheenen, Roan Hugo van Scheppingen, Tim Schelfhorst, Evelyne Beerling

Publikováno v: Cell Reports, Vol 29, Iss 9, Pp 2565-2569.e3 (2019)
Cell Reports

Summary Epithelial-to-mesenchymal transition (EMT) has long been thought to be crucial for metastasis. Recently a study challenged this idea by demonstrating that metastases were seeded by tumor cells that were not marked by an EMT lineage-tracing re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ee83772378e56bdd13841059673212
http://www.sciencedirect.com/science/article/pii/S2211124719314408