Výsledky vyhledávání - "Danielle Sakaguchi"

Akademický článek

Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito host.

Autor: Shirley Luckhart, Cecilia Giulivi, Anna L Drexler, Yevgeniya Antonova-Koch, Danielle Sakaguchi, Eleonora Napoli, Sarah Wong, Mark S Price, Richard Eigenheer, Brett S Phinney, Nazzy Pakpour, Jose E Pietri, Kong Cheung, Martha Georgis, Michael Riehle

Publikováno v: PLoS Pathogens, Vol 9, Iss 2, p e1003180 (2013)

The overexpression of activated, myristoylated Akt in the midgut of female transgenic Anopheles stephensi results in resistance to infection with the human malaria parasite Plasmodium falciparum but also decreased lifespan. In the present study, the

Externí odkaz: https://doaj.org/article/99294b45341f4171b2ab2753d7b9d32e

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Akademický článek

Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53.

Autor: Eleonora Napoli, Catherine Ross-Inta, Sarah Wong, Connie Hung, Yasuko Fujisawa, Danielle Sakaguchi, James Angelastro, Alicja Omanska-Klusek, Robert Schoenfeld, Cecilia Giulivi

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e42504 (2012)

Etiology of aberrant social behavior consistently points to a strong polygenetic component involved in fundamental developmental pathways, with the potential of being enhanced by defects in bioenergetics. To this end, the occurrence of social deficit

Externí odkaz: https://doaj.org/article/71c772efedd048fd82f068891ea8be5c

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Clinical evaluation and biochemical analyses of thiamine deficiency in Pacific harbor seals (Phoca vitulina) maintained at a zoological facility

Autor: Cecilia R Giulivi, Birgit Puschner, Judy St. Leger, Lara A. Croft, Danielle Sakaguchi, Scott Gearhart, Eleonora Napoli, Connie Hung, Alex Lin, Sarah Wong, Kathy Heym

Publikováno v: Journal of the American Veterinary Medical Association, vol 243, iss 8

Objective—To determine thiamine-dependent enzyme activities in various tissue samples of Pacific harbor seals (Phoca vitulina) and thiaminase activities in dietary fish. Design—Cross-sectional study. Animals—11 Pacific harbor seals with thiamin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e47a7eb8886883015ec9a42701ea93
https://pubmed.ncbi.nlm.nih.gov/24094267

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Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53

Autor: Sarah Wong, Connie Hung, Danielle Sakaguchi, Yasuko Fujisawa, Robert Schoenfeld, James M. Angelastro, Cecilia R Giulivi, Alicja Omanska-Klusek, Catherine Ross-Inta, Eleonora Napoli

Publikováno v: PloS one, vol 7, iss 8
PLoS ONE, Vol 7, Iss 8, p e42504 (2012)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353caea7ef581e5692674bb9e2cca373
https://escholarship.org/uc/item/03v7x3cx

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Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome

Autor: Alicja Omanska-Klusek, Eleonora Napoli, Dolores Garcia-Arocena, Cedrick Barrow, Christine Iwahashi, Catherine Ross-Inta, Paul J. Hagerman, Elizabeth Berry-Kravis, Randi J Hagerman, Danielle Sakaguchi, Cecilia R Giulivi, Sarah Wong

Publikováno v: Human molecular genetics. 20(15)

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder that affects individuals who are carriers of small CGG premutation expansions in the fragile X mental retardation 1 (FMR1) gene. Mitochondrial dysfunction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbbbb595e20d8ea54b869fa8decf0e3
https://pubmed.ncbi.nlm.nih.gov/21558427

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Basal bioenergetic abnormalities in skeletal muscle from ryanodine receptor malignant hyperthermia-susceptible R163C knock-in mice

Autor: Genaro C. Barrientos, Alicja Omanska-Klusek, Isaac N. Pessah, Paul D. Allen, Eleonora Napoli, Cecilia R Giulivi, Catherine Ross-Inta, Danielle Sakaguchi

Publikováno v: The Journal of biological chemistry. 286(1)

Malignant hyperthermia (MH) and central core disease in humans have been associated with mutations in the skeletal ryanodine receptor (RyR1). Heterozygous mice expressing the human MH/central core disease RyR1 R163C mutation exhibit MH when exposed t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48580fbfb36bb294324b8fb28646476d
https://pubmed.ncbi.nlm.nih.gov/20978128

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