Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Danielle R. Lenz"'
Autor:
Will J. McLean, Xiaolei Yin, Lin Lu, Danielle R. Lenz, Dalton McLean, Robert Langer, Jeffrey M. Karp, Albert S.B. Edge
Publikováno v:
Cell Reports, Vol 18, Iss 8, Pp 1917-1929 (2017)
Death of cochlear hair cells, which do not regenerate, is a cause of hearing loss in a high percentage of the population. Currently, no approach exists to obtain large numbers of cochlear hair cells. Here, using a small-molecule approach, we show sig
Externí odkaz:
https://doaj.org/article/f3b55648d3544013aa8e9910b16c2295
Autor:
Danielle R. Lenz, Niliksha Gunewardene, Dunia E. Abdul-Aziz, Quan Wang, Tyler M. Gibson, Albert S. B. Edge
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
The mouse cochlea contains approximately 15,000 hair cells. Its dimensions and location, and the small number of hair cells, make mechanistic, developmental and cellular replacement studies difficult. We recently published a protocol to expand and di
Externí odkaz:
https://doaj.org/article/40c086e4f97d47959e0cc5e925f4eb01
Autor:
Craig Hanna, Beatrice Milon, Amol C. Shetty, Carlo Colantuoni, Ramesh A. Shivdasani, Dunia Abdul-Aziz, Gurmannat Kalra, Danielle R. Lenz, Seth A. Ament, Ronna Hertzano, Brian R. Herb, Albert S.B. Edge, Madhurima Saxena
We explored the transcriptional and epigenetic programs underlying the differentiation of hair cells from postnatal progenitor cells in cochlear organoids. Heterogeneity in the cells including cells with the transcriptional signatures of mature hair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad8953b932da8e596743b8cd1db1ca60
https://doi.org/10.1101/2021.09.19.460948
https://doi.org/10.1101/2021.09.19.460948
Autor:
Eyal Raveh, Danielle R. Lenz, Roy Hod, Ben I. Nageris, Joseph Attias, Aviram Mizrachi, Karen B. Avraham
Publikováno v:
American Journal of Otolaryngology. 37:162-168
The mechanism and the type of hearing loss induced by cochlear implants are mostly unknown. Therefore, this study evaluated the impact and type of hearing loss induced by each stage of cochlear implantation surgery in an animal model.Original basic r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e10a8da75735d8fe52762d9e4b5981b
https://doi.org/10.1016/j.amjoto.2015.12.004
https://doi.org/10.1016/j.amjoto.2015.12.004
Autor:
Danielle R. Lenz, Rory Kirchner, Lihong Xie, Hao Chiang, Anshula Samarajeewa, Albert S.B. Edge, Joanna F. Mulvaney, Alain Dabdoub
Publikováno v:
Development (Cambridge, England)
Lack of sensory hair cell (HC) regeneration in mammalian adults is a major contributor to hearing loss. In contrast, the neonatal mouse cochlea retains a transient capacity for regeneration, and forced Wnt activation in neonatal stages promotes suppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b110e93ba5edc02f68d92014e709b381
https://doi.org/10.1242/dev.166579
https://doi.org/10.1242/dev.166579
Autor:
Dalton McLean, William McLean, Xiaolei Yin, Danielle R. Lenz, Robert Langer, Albert S.B. Edge, Lin Lu, Jeffrey M. Karp
Publikováno v:
Elsevier
Cell Reports, Vol 18, Iss 8, Pp 1917-1929 (2017)
Cell Reports, Vol 18, Iss 8, Pp 1917-1929 (2017)
Death of cochlear hair cells, which do not regenerate, is a cause of hearing loss in a high percentage of the population. Currently, no approach exists to obtain large numbers of cochlear hair cells. Here, using a small-molecule approach, we show sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9065bf769292dbf671ba3b34eae094cc
https://orcid.org/0000-0001-8624-8928
https://orcid.org/0000-0001-8624-8928
Publikováno v:
Journal of Clinical Investigation. 123:3712-3715
The two compositionally distinct extracellular cochlear fluids, endolymph and perilymph, are separated by tight junctions that outline the scala media and reticular lamina. Mutations in TRIC (also known as MARVELD2), which encodes a tricellular tight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846210d11eb8861520c8158f81f9e244
https://doi.org/10.1172/jci69651
https://doi.org/10.1172/jci69651
Autor:
Moshe Frydman, Daphne Karfunkel, Martin Hrabé de Angelis, Sibylle Sabrautzki, Birgit Rathkolb, Danielle R. Lenz, Manuela Mohr, Eckhard Wolf, Yisgav Shapira, Shaked Shivatzki, Karen B. Avraham, Zippora Brownstein, Kathy Ushakov, Michael Wolf, Thomas Parzefall
Publikováno v:
Human Mutation. 34:1102-1110
POU3F4 is a POU domain transcription factor that is required for hearing. In the ear, POU3F4 is essential for mesenchymal remodeling of the bony labyrinth and is the causative gene for DFNX2 human nonsyndromic deafness. Ear abnormalities underlie thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7155a2300aa491fc7929f8930e7119
https://doi.org/10.1002/humu.22339
https://doi.org/10.1002/humu.22339
Autor:
Karen B. Avraham, Danielle R. Lenz
Publikováno v:
Hearing Research. 281:3-10
The genetic heterogeneity of hereditary hearing loss is thus far represented by hundreds of genes encoding a large variety of proteins. Mutations in these genes have been discovered for patients with different modes of inheritance and types of hearin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41aacb0a8994cce0dbc7deeeb8b41a94
https://doi.org/10.1016/j.heares.2011.05.021
https://doi.org/10.1016/j.heares.2011.05.021
Autor:
Yael Politi, Amiel A. Dror, Silvia Dossena, Hashem Shahin, Karen B. Avraham, Steve Weiner, Danielle R. Lenz, Martin Hrabé de Angelis, Charity Nofziger, Markus Paulmichl, Helmut Fuchs
Publikováno v:
J. Biol. Chem. 285, 21724-21735 (2010)
Calcium oxalate stone formation occurs under pathological conditions and accounts for more than 80% of all types of kidney stones. In the current study, we show for the first time that calcium oxalate stones are formed in the mouse inner ear of a gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c406b0853aaee6d3742dd6d13ebbcad
https://doi.org/10.1074/jbc.m110.120188
https://doi.org/10.1074/jbc.m110.120188