Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Danielle R. Armas"'
Autor:
Fady I. Malik, Laura A. Robertson, Danielle R. Armas, Edward P. Robbie, Anna Osmukhina, Donghong Xu, Hanbin Li, Scott D. Solomon
Publikováno v:
JACC. Basic to translational science. 7(8)
This phase 1, randomized, double-blind, placebo-controlled study of aficamten (formerly CK-3773274) in healthy adults identified a pharmacologically active range of doses and exposures. At doses that were pharmacologically active (single doses of ≤
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9424f67d2ab2637628a285990168c039
https://pubmed.ncbi.nlm.nih.gov/36061336
https://pubmed.ncbi.nlm.nih.gov/36061336
Autor:
Danielle R. Armas, Fady I. Malik, Anna Osmukhina, Edward Robbie, Scott D. Solomon, Hanbin Li, Laura A. Robertson
Publikováno v:
Journal of Cardiac Failure. 25:S79-S80
Introduction Hypercontractility of the cardiac sarcomere appears to underlie pathological hypertrophy and fibrosis in select genetic hypertrophic cardiomyopathies (HCM). CK-3773274 (CK-274) decreases systolic function in preclinical models by directl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6ca4edb88b7911d75a2a0775b457e4f
https://doi.org/10.1016/j.cardfail.2019.07.225
https://doi.org/10.1016/j.cardfail.2019.07.225