Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Danielle Pomante"'
Autor:
Claudia Capparelli, Timothy J. Purwin, McKenna Glasheen, Signe Caksa, Manoela Tiago, Nicole Wilski, Danielle Pomante, Sheera Rosenbaum, Mai Q. Nguyen, Weijia Cai, Janusz Franco-Barraza, Richard Zheng, Gaurav Kumar, Inna Chervoneva, Ayako Shimada, Vito W. Rebecca, Adam E. Snook, Kim Hookim, Xiaowei Xu, Edna Cukierman, Meenhard Herlyn, Andrew E. Aplin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Mechanisms underlying tumor cell plasticity remain poorly understood. Here, the authors show the presence of a dormant-invasive SOX10- subpopulation in cutaneous melanoma that can be targeted by cIAP1/2 inhibitors.
Externí odkaz:
https://doaj.org/article/59cac3fded2d4f39825e28a5697d2477
Autor:
Megane Vernon, Nicole A. Wilski, Daniel Kotas, Weijia Cai, Danielle Pomante, Manoela Tiago, Emad S. Alnemri, Andrew E. Aplin
Publikováno v:
Mol Cancer Res
Lack of response and acquired resistance continue to be limitations of targeted and immune-based therapies. Pyroptosis is an inflammatory form of cell death characterized by the release of inflammatory damage-associated molecular patterns (DAMP) and
Autor:
Andrew E. Aplin, Emad S. Alnemri, Manoela Tiago, Danielle Pomante, Weijia Cai, Daniel Kotas, Nicole A. Wilski, Megane Vernon
Supplementary Figure from Raptinal Induces Gasdermin E–Dependent Pyroptosis in Naïve and Therapy-Resistant Melanoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5ebf1eb06a741eb37fa22813edc768
https://doi.org/10.1158/1541-7786.22528043
https://doi.org/10.1158/1541-7786.22528043
Autor:
Claudia, Capparelli, Timothy J, Purwin, McKenna, Glasheen, Signe, Caksa, Manoela, Tiago, Nicole, Wilski, Danielle, Pomante, Sheera, Rosenbaum, Mai Q, Nguyen, Weijia, Cai, Janusz, Franco-Barraza, Richard, Zheng, Gaurav, Kumar, Inna, Chervoneva, Ayako, Shimada, Vito W, Rebecca, Adam E, Snook, Kim, Hookim, Xiaowei, Xu, Edna, Cukierman, Meenhard, Herlyn, Andrew E, Aplin
Publikováno v:
Nature communications. 13(1)
Cellular plasticity contributes to intra-tumoral heterogeneity and phenotype switching, which enable adaptation to metastatic microenvironments and resistance to therapies. Mechanisms underlying tumor cell plasticity remain poorly understood. SOX10,
Autor:
Sonsoles Piera-Velazquez, Fabian A. Mendoza, Sankar Addya, Danielle Pomante, Sergio A. Jimenez
Publikováno v:
Clinical and experimental rheumatology. 39(6)
Systemic sclerosis (SSc) is characterised by severe fibroproliferative vasculopathy, fibrosis in skin and multiple internal organs, and humoral, cellular and innate immunity abnormalities. Vascular alterations are the earliest and most severe SSc man
Autor:
Sheera R. Rosenbaum, Manoela Tiago, Signe Caksa, Claudia Capparelli, Timothy J. Purwin, Gaurav Kumar, McKenna Glasheen, Danielle Pomante, Daniel Kotas, Inna Chervoneva, Andrew E. Aplin
Publikováno v:
Cell reports
SUMMARY Developmental factors may regulate the expression of immune modulatory proteins in cancer, linking embryonic development and cancer cell immune evasion. This is particularly relevant in melanoma because immune checkpoint inhibitors are common
Autor:
Weijia Cai, Adam E. Snook, McKenna Glasheen, Inna Chervoneva, Sheera Rosenbaum, Ayako Shimada, Mai Q. Nguyen, Andrew E. Aplin, Danielle Pomante, Claudia Capparelli, Xiaowei Xu, Manoela Tiago, Kim HooKim, Timothy J. Purwin, Michael A. Davies, Meenhard Herlyn, Edna Cukierman, Gaurav Kumar, Nicole A. Wilski, Richard Zheng, Paolo Fortina
Publikováno v:
Cancer Research. 81:40-40
Intratumoral heterogeneity and cellular plasticity enable tumors to alter phenotypes and adapt to foreign microenvironments and resist targeted inhibitors. While the ability to switch between phenotypic states has been broadly characterized, the key