Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila.

Autor: Augusto V Gonçalves, Shally R Margolis, Gustavo F S Quirino, Danielle P A Mascarenhas, Isabella Rauch, Randilea D Nichols, Eduard Ansaldo, Mary F Fontana, Russell E Vance, Dario S Zamboni

Publikováno v: PLoS Pathogens, Vol 15, Iss 6, p e1007886 (2019)

Inflammasomes are cytosolic multi-protein complexes that detect infection or cellular damage and activate the Caspase-1 (CASP1) protease. The NAIP5/NLRC4 inflammasome detects bacterial flagellin and is essential for resistance to the flagellated intr

Externí odkaz: https://doaj.org/article/59137ac06adb47fd85a53405d252b437

AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome

Autor: Leonardo L. Santos, Richard A. Flavell, Larissa D. Cunha, Gustavo Fernando da Silva Quirino, Dario S. Zamboni, Danielle P. A. Mascarenhas, Juliana M. Ribeiro, Alexandre L. N. Silva

Publikováno v: Cell Reports, Vol 20, Iss 4, Pp 794-805 (2017)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Summary Inflammasomes are multimeric protein complexes that initiate inflammatory cascades. Their activation is a hallmark of many infectious or inflammatory diseases. Their composition and activity are specified by proinflammatory stimuli. For examp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e331321794ab179f9c597961da82fb3
http://www.sciencedirect.com/science/article/pii/S2211124717309348

Inflammasome Activation in Legionella-Infected Macrophages

Autor: Dario S. Zamboni, Danielle P. A. Mascarenhas

Publikováno v: Methods in Molecular Biology ISBN: 9781493990474

Legionella pneumophila is a gram-negative bacterium that infects many species of unicellular protozoa in freshwater environments. The human infection is accidental, and the bacteria may not have evolved strategies to bypass innate immune signaling in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d084149cf167e95661f57589a1d568dd
https://doi.org/10.1007/978-1-4939-9048-1_20

Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome

Autor: Graziele Z. Manin, Fernanda V. S. Castanheira, Talita D. Fernandes, Danielle P. A. Mascarenhas, Daiane M. Cerqueira, Larissa D. Cunha, Marcelo S. F. Pereira, Dario S. Zamboni

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 8, p e1006502 (2017)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Legionella pneumophila is a Gram-negative, flagellated bacterium that survives in phagocytes and causes Legionnaires’ disease. Upon infection of mammalian macrophages, cytosolic flagellin triggers the activation of Naip/NLRC4 inflammasome, which cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2432538b558c6c77db6e6631c3d038
http://europepmc.org/articles/PMC5542441

Inflammasome biology taught by

Autor: Danielle P A, Mascarenhas, Dario S, Zamboni

Publikováno v: Journal of leukocyte biology. 101(4)

Inflammasomes are multimeric protein complexes that assemble in the cytosol of many types of cells, including innate immune cells. The inflammasomes can be activated in response to infection or in response to stress signals that induce damage in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2f98b8b19d2c37ab8dfd53130410d32
https://pubmed.ncbi.nlm.nih.gov/27999148