Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Danielle Nessem"'
Autor:
Man-Tat Lau, Shila Ghazanfar, Ashleigh Parkin, Angela Chou, Jourdin R. Rouaen, Jamie B. Littleboy, Danielle Nessem, Thang M. Khuong, Damien Nevoltris, Peter Schofield, David Langley, Daniel Christ, Jean Yang, Marina Pajic, G. Gregory Neely
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background Drug resistance is a major obstacle in cancer therapy. To elucidate the genetic factors that regulate sensitivity to anti-cancer drugs, we performed CRISPR-Cas9 knockout screens for resistance to a spectrum of drugs. Results In ad
Externí odkaz:
https://doaj.org/article/c47471a679ca416996391ad2844c7411
Autor:
Jean-Yves Blay, Shivakumar Keerthikumar, Marina Pajic, Simon Junankar, Darren N. Saunders, Uyen Nguyen, Anthony T. Papenfuss, Paul Timpson, Ana Cristina Vargas, David Thomas, David R. Croucher, David L Goode, Danielle Nessem, Alvaro Gonzalez Rajal, Sean C. Warren, Min Ru Qiu, Mark J. McCabe, Georgina V. Long, Justin Bedo, Niall M. Corcoran, Max Nobis, Mark J. Cowley, Pavel Lobachevsky, Daniele Generali, Arcadi Cipponi
Publikováno v:
Science. 368:1127-1131
How cancer cells adapt to stress Bacteria adapt to harsh conditions such as antibiotic exposure by acquiring new mutations, a process called stress-induced mutagenesis. Cipponi et al. investigated whether similar programs of mutagenesis play a role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9fcede3e7a71227c2ed74c18a602b5
https://doi.org/10.1126/science.aau8768
https://doi.org/10.1126/science.aau8768
Autor:
Peter R. Schofield, Man-Tat Lau, Jean Yang, David B. Langley, Thang M. Khuong, Danielle Nessem, Marina Pajic, Daniel Christ, Angela Chou, Jourdin R. Rouaen, Jamie B. Littleboy, Damien Nevoltris, Shila Ghazanfar, G. Gregory Neely, Ashleigh Parkin
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-12 (2020)
Genome Biology
Genome Biology
Background Drug resistance is a major obstacle in cancer therapy. To elucidate the genetic factors that regulate sensitivity to anti-cancer drugs, we performed CRISPR-Cas9 knockout screens for resistance to a spectrum of drugs. Results In addition to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922824cb7feafff70032b0460cca2622
https://doaj.org/article/c47471a679ca416996391ad2844c7411
https://doaj.org/article/c47471a679ca416996391ad2844c7411
Autor:
Adelaide I. J. Young, Paul Timpson, Amanda Mawson, Ashleigh Parkin, Danielle Nessem, David Gallego-Ortega, Pia Schafranek, Samantha R. Oakes, Catherine E Caldon, Angela Steinmann, Andrew M. K. Law, Angela Chou, Niantao Deng, Christopher J. Ormandy, Morghan C. Lucas, Lesley Castillo, Marina Pajic, Kendelle J. Murphy, Amber L. Johns
Publikováno v:
Oncogene
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies. It is phenotypically heterogeneous with a highly unstable genome and provides few common therapeutic targets. We found that MCL1, Cofilin1 (CFL1) and SRC mRNA were hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bbd8992ce18e36adc02f31e5d4a292
http://europepmc.org/articles/PMC7033042
http://europepmc.org/articles/PMC7033042