Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Danielle N. Confair"'
Autor:
Anat Levit Kaplan, Danielle N. Confair, Kuglae Kim, Ximena Barros-Álvarez, Ramona M. Rodriguiz, Ying Yang, Oh Sang Kweon, Tao Che, John D. McCorvy, David N. Kamber, James P. Phelan, Luan Carvalho Martins, Vladimir M. Pogorelov, Jeffrey F. DiBerto, Samuel T. Slocum, Xi-Ping Huang, Jain Manish Kumar, Michael J. Robertson, Ouliana Panova, Alpay B. Seven, Autumn Q. Wetsel, William C. Wetsel, John J. Irwin, Georgios Skiniotis, Brian K. Shoichet, Bryan L. Roth, Jonathan A. Ellman
Publikováno v:
Nature. 610:582-591
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baa77bd0c4ea2800539996a89d21473e
https://doi.org/10.1038/s41586-022-05258-z
https://doi.org/10.1038/s41586-022-05258-z
Publikováno v:
Org Lett
A Rh(III)-catalyzed synthesis of bicyclic [1,3,5]triazinones from a diverse array of imines coupled with ethyl (pivaloyloxy)carbamate is reported. The preparation of [5,6]- and [6,6]-bicyclic heterocycles substituted with aryl, alkyl, and alkoxy grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa0e3ef5cbc119360962e8490de6b31
https://doi.org/10.1021/acs.orglett.0c03393
https://doi.org/10.1021/acs.orglett.0c03393
Autor:
Anat Levit, Kaplan, Danielle N, Confair, Kuglae, Kim, Ximena, Barros-Álvarez, Ramona M, Rodriguiz, Ying, Yang, Oh Sang, Kweon, Tao, Che, John D, McCorvy, David N, Kamber, James P, Phelan, Luan Carvalho, Martins, Vladimir M, Pogorelov, Jeffrey F, DiBerto, Samuel T, Slocum, Xi-Ping, Huang, Jain Manish, Kumar, Michael J, Robertson, Ouliana, Panova, Alpay B, Seven, Autumn Q, Wetsel, William C, Wetsel, John J, Irwin, Georgios, Skiniotis, Brian K, Shoichet, Bryan L, Roth, Jonathan A, Ellman
Publikováno v:
Nature. 610(7932)
There is considerable interest in screening ultralarge chemical libraries for ligand discovery, both empirically and computationally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00b88e8046eebb9e1ac9ae4b9b328715
https://pubmed.ncbi.nlm.nih.gov/36284180
https://pubmed.ncbi.nlm.nih.gov/36284180
Publikováno v:
Acc Chem Res
Nitrogen heterocycles are present in approximately 60% of drugs, with nonplanar heterocycles incorporating stereogenic centers being of considerable interest to the fields of medicinal chemistry, chemical biology, and synthetic methods development. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88496c1fb08c12fc746a867190d0b322
https://pubmed.ncbi.nlm.nih.gov/33740369
https://pubmed.ncbi.nlm.nih.gov/33740369
Publikováno v:
The Journal of organic chemistry. 83(20)
Ketones readily undergo conversion to enol silanes in the presence of a trialkylamine base and trimethylsilyl trifluoromethanesulfonate (TMSOTf) and add to propargyl cations to yield β-alkynyl ketones. The propargyl cations are generated in the same
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803cbbf75c3f963acb1ba84d44e89f07
https://pubmed.ncbi.nlm.nih.gov/30248260
https://pubmed.ncbi.nlm.nih.gov/30248260
Herein, we report a Rh(I)/bisphosphine/K3PO4 catalytic system allowing for the first time the selective branched C–H alkylation of benzimidazoles with Michael acceptors. Branched alkylation with N,N-dimethyl acrylamide was successfully applied to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0978619aea353cde90823f69199e715d
https://europepmc.org/articles/PMC5585739/
https://europepmc.org/articles/PMC5585739/
Autor:
Sarah E. Covington, Derek C. Obenschain, James T. Rague, Evan Halliday, C. Wade Downey, Danielle N. Confair
Publikováno v:
Tetrahedron Letters. 55:5213-5215
para-Methoxybenzyl methyl ether acts as an alkylating agent for thiols in the presence of trimethylsilyl trifluoromethanesulfonate and trialkylamine base in good yields (58–96%). Aryl ketones are alkylated under similar conditions, probably through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aa3ef271dd77d5838344131d65b8108
https://doi.org/10.1016/j.tetlet.2014.07.068
https://doi.org/10.1016/j.tetlet.2014.07.068
Silyl triflate-accelerated additions of catalytically generated zinc acetylides to N-phenyl nitrones
Publikováno v:
Tetrahedron Letters. 55:4959-4961
Terminal alkynes readily form zinc acetylides in the presence of iPr2NEt and 20 mol % ZnBr2, then attack N-phenyl nitrones activated by trimethylsilyl trifluoromethanesulfonate. Deprotection with aqueous acid yields N-hydroxyl propargylamine. Yields
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0067a15acf8d0508149bd0315719f8a9
https://doi.org/10.1016/j.tetlet.2014.07.015
https://doi.org/10.1016/j.tetlet.2014.07.015
Autor:
C. Wade Downey, Sarah E. Covington, Derek C. Obenschain, Danielle N. Confair, Evan Halliday, James T. Rague
Publikováno v:
ChemInform. 46
para-Methoxybenzyl methyl ether acts as an alkylating agent for thiols in the presence of trimethylsilyl trifluoromethanesulfonate and trialkylamine base in good yields (58–96%). Aryl ketones are alkylated under similar conditions, probably through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bccddd31f18ac08871c44ee610078b6d
https://doi.org/10.1002/chin.201508054
https://doi.org/10.1002/chin.201508054
Publikováno v:
ChemInform. 46
After deprotection with TosOH in MeOH the free N-hydroxyl propargylamines are obtained, whereas the Tms-protected products (VI) are isolated due to decomposition of the products during the removal of the Tms group, in some cases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a62aea44f3ad3323a33df2856732a30d
https://doi.org/10.1002/chin.201506076
https://doi.org/10.1002/chin.201506076