Koala ocular disease grades are defined by chlamydial load changes and increases in Th2 immune responses

Autor: Samuel Phillips, Danielle Madden, Amber Gillett, Bonnie L. Quigley, Martina Jelocnik, Sankhya Bommana, Denis O’Meally, Peter Timms, Adam Polkinghorne

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

IntroductionThis study employs bulk RNA sequencing, PCR, and ELISA assays to analyze the pathological factors affecting the outcomes of C. pecorum ocular infections in koalas. It investigates the immune responses and gene expression profiles associat

Externí odkaz: https://doaj.org/article/193651c3cc854f3385c2cf9dcea46c14

Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala

Autor: Erin Harvey, Danielle Madden, Adam Polkinghorne, Edward C. Holmes

Publikováno v: Viruses, Vol 11, Iss 3, p 211 (2019)

Koalas (Phascolarctos cinereus) are native Australian marsupials whose populations are in decline from a range of threats. Infectious diseases caused by the bacterium Chlamydia pecorum and other pathogens are of particular concern. We analysed 26 pol

Externí odkaz: https://doaj.org/article/33603c1dd64545edb2421989690a7691

Taking the next-gen step: Comprehensive antimicrobial resistance detection from Burkholderia pseudomallei

Autor: Jessica R. Webb, Bart J. Currie, Danielle Madden, Erin P. Price, Derek S. Sarovich, Eike J. Steinig

Publikováno v: EBioMedicine, Vol 63, Iss, Pp 103152-(2021)
EBioMedicine

Background Antimicrobial resistance (AMR) poses a major threat to human health. Whole-genome sequencing holds great potential for AMR identification; however, there remain major gaps in accurately and comprehensively detecting AMR across the spectrum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d1502f5f9dd0666abb6fcc5bd7cac4
http://www.sciencedirect.com/science/article/pii/S2352396420305284

Adaptation and conservation insights from the koala genome

Autor: Danielle Madden, Camilla M. Whittington, Rachel J. O’Neill, Simon Y. W. Ho, Zhiliang Chen, Marilyn B. Renfree, Val Attenbrow, Andrew King, Graham J Etherington, Siobhan Dennison, Parice A. Brandies, David E. Alquezar-Planas, Emma Peel, Amber Gillett, Yuanyuan Cheng, Jennifer A. Marshall Graves, Thomas N. Heider, Greta J. Frankham, Donald J. Colgan, Elizabeth A. Jones, Katherine Belov, Carolyn J. Hogg, Janine E. Deakin, Federica Di Palma, Charles Robin, Catherine E. Grueber, Zachary Duda, Denis O’Meally, Alex D. Greenwood, Jason G. Bragg, Takashi Hayakawa, Clare E. Holleley, Amanda Yoon Yee Chong, Ryan Salinas, Matthew Hobbs, Belinda Wright, Will Nash, Arthur Georges, Kyle M. Ewart, Mark D. B. Eldridge, Adam Polkinghorne, Rebecca N. Johnson, Paul D. Waters, Peter Timms, Shafagh A. Waters, Merran Govendir, Katrina M. Morris, Tonia Russell, Kyriakos Tsangaras, Wilfried Haerty, Hardip R. Patel, Linda E. Neaves, Kristofer M. Helgen, Marc R. Wilkins

Publikováno v: Johnson, R N, O'Meally, D, Chen, Z, Etherington, G J, Ho, S Y W, Nash, W J, Grueber, C E, Cheng, Y, Whittington, C M, Dennison, S, Peel, E, Haerty, W, O'Neill, R J, Colgan, D, Russell, T L, Alquezar-Planas, D E, Attenbrow, V, Bragg, J G, Brandies, P A, Chong, A Y-Y, Deakin, J E, Di Palma, F, Duda, Z, Eldridge, M D B, Ewart, K M, Hogg, C J, Frankham, G J, Georges, A, Gillett, A K, Govendir, M, Greenwood, A D, Hayakawa, T, Helgen, K M, Hobbs, M, Holleley, C E, Heider, T N, Jones, E A, King, A, Madden, D, Graves, J A M, Morris, K M, Neaves, L E, Patel, H R, Polkinghorne, A, Renfree, M B, Robin, C, Salinas, R, Tsangaras, K, Waters, P D & Waters, S A 2018, ' Adaptation and conservation insights from the koala genome ', Nature Genetics, vol. 50, no. 8, pp. 1102-1111 . https://doi.org/10.1038/s41588-018-0153-5
Nature Genetics
Nature genetics, 50:1102–1111

The koala, the only extant species of the marsupial family Phascolarctidae, is classified as ‘vulnerable’ due to habitat loss and widespread disease. We sequenced the koala genome, producing a complete and contiguous marsupial reference genome, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af100bb35684bb2ad32daceb8df8e97
https://hdl.handle.net/20.500.11820/ebdf3be6-51d2-4fde-9233-0c76827d8988

Koala immunology and infectious diseases: How much can the koala bear?

Autor: Katherine Belov, Elizabeth A. Jones, Danielle Madden, Adam Polkinghorne, Alessandra D. Whaite, Peter Timms

Publikováno v: Developmental and comparative immunology. 82

Infectious diseases are contributing to the decline of the iconic Australian marsupial, the koala (Phascolarctos cinereus). Infections with the obligate intracellular bacteria, Chlamydia pecorum, cause debilitating ocular and urogenital-tract disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aff864e648fb443b9365549c5f8059c
https://pubmed.ncbi.nlm.nih.gov/29382557