Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Danielle M. Fowler"'
Autor:
Daniel Grabowski, Jörg Kley, Daniel Bischoff, Danielle M. Fowler, Robert Ries, Sarah Chandler, Carola Kleiner, John Broadwater, Martin Winter, Christina Bartlett, Ralph Binetti, Sven Thamm, Andreas H. Luippold, Tom Bretschneider, Frank H. Büttner
Publikováno v:
SLAS discovery : advancing life sciences RD. 24(7)
Microbial-dependent trimethylamine (TMA) generation from dietary precursors such as choline was recently linked to cardiovascular diseases (CVDs) as well as chronic kidney disease (CKD). Inhibition of TMA-generating enzymes in gut bacteria would be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f4401d7f3d5f2d3a59aa91a2b60df6
https://pubmed.ncbi.nlm.nih.gov/31059309
https://pubmed.ncbi.nlm.nih.gov/31059309
Autor:
Ming-Hong Hao, E. Michael August, Danielle M. Fowler, Jin Mi Kim, Neil A. Farrow, Stéphane De Lombaert, Peter Allen Nemoto, Hidenori Takahashi, Leslie Martin, Daniel R. Albaugh, Steven S. Pullen, Kevin Chungeng Qian, Ho Yin Lo, Melissa Hill-Drzewi, Richard D. Schneiderman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4533-4539
A new class of chymase inhibitor featuring a benzimidazolone core with an acid side chain and a P1 hydrophobic moiety is described. Incubation of the lead compound with GSH resulted in the formation of a GSH conjugate on the benzothiophene P1 moiety.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df6a496eb118478cab46c6fde2569f9
https://doi.org/10.1016/j.bmcl.2011.05.126
https://doi.org/10.1016/j.bmcl.2011.05.126